Resting Energy Expenditure Is Not Altered in Children and Adolescents with Obesity. Effect of Age and Gender and Association with Serum Leptin Levels

In children and adolescents, obesity does not seem to depend on a reduction of resting energy expenditure (REE). Moreover, in this young population, the interactions between either age and obesity or between age and gender, or the role of leptin on REE are not clearly understood. To compare the levels of REE in children and adolescents we studied 181 Caucasian individuals (62% girls) classified on the basis of age- and sex-specific body mass index (BMI) percentile as healthy weight (n = 50), with overweight (n = 34), or with obesity (n = 97) and in different age groups: 8–10 (n = 38), 11–13 (n = 50), and 14–17 years (n = 93). REE was measured by indirect calorimetry and body composition by air displacement plethysmography. Statistically significant differences in REE/fat-free mass (FFM) regarding obesity or gender were not observed. Absolute REE increases with age (p < 0.001), but REE/FFM decreases (p < 0.001) and there is an interaction between gender and age (p < 0.001) on absolute REE showing that the age-related increase is more marked in boys than in girls, in line with a higher FFM. Interestingly, the effect of obesity on absolute REE is not observed in the 8–10 year-old group, in which serum leptin concentrations correlate with the REE/FFM (r = 0.48; p = 0.011). In conclusion, REE/FFM is not affected by obesity or gender, while the effect of age on absolute REE is gender-dependent and leptin may influence the REE/FFM in 8–10 year-olds.

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Is a low serum adiponectin or high serum leptin associated with a low resting energy expenditure (REE) in overweight or obese children and adolescents?

The FASEB Journal ◽

10.1096/fasebj.26.1_supplement.820.14 ◽

2012 ◽

Vol 26 (S1) ◽

Author(s):

Myung-Hee Kim ◽

Eun-Kyung Kim

Keyword(s):

Energy Expenditure ◽

Children And Adolescents ◽

Resting Energy Expenditure ◽

High Serum ◽

Serum Adiponectin ◽

Obese Children ◽

Serum Leptin ◽

Low Serum ◽

Resting Energy

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The Influence of Age and Gender on Resting Energy Expenditure in Severely Burned Children

Annals of Surgery ◽

10.1097/01.sla.0000217678.78472.d3 ◽

2006 ◽

Vol 244 (1) ◽

pp. 121-130 ◽

Cited By ~ 66

Author(s):

Ronald P. Mlcak ◽

Marc G. Jeschke ◽

Robert E. Barrow ◽

David N. Herndon

Keyword(s):

Energy Expenditure ◽

Resting Energy Expenditure ◽

Age And Gender ◽

And Gender ◽

Resting Energy

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Comparison of predictive equations for resting energy expenditure (REE) in obese and nonobese children and adolescents

The FASEB Journal ◽

10.1096/fasebj.25.1_supplement.lb220 ◽

2011 ◽

Vol 25 (S1) ◽

Author(s):

Myung‐Hee Kim ◽

Eun‐Kyung Kim

Keyword(s):

Energy Expenditure ◽

Children And Adolescents ◽

Resting Energy Expenditure ◽

Predictive Equations ◽

Resting Energy

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Resting Energy Expenditure of Children and Adolescents With Nonalcoholic Fatty Liver Disease

Journal of Parenteral and Enteral Nutrition ◽

10.1177/0148607116658761 ◽

2016 ◽

Vol 41 (7) ◽

pp. 1195-1201 ◽

Cited By ~ 2

Author(s):

Inez Martincevic ◽

Marialena Mouzaki

Keyword(s):

Liver Disease ◽

Energy Expenditure ◽

Fatty Liver ◽

Children And Adolescents ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Resting Energy Expenditure ◽

Nonalcoholic Fatty Liver ◽

Resting Energy

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Resting energy expenditure in girls with Turner syndrome

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2016-0295 ◽

2017 ◽

Vol 30 (3) ◽

Author(s):

Gerhard Binder ◽

Laura Frank ◽

Julian Ziegler ◽

Gunnar Blumenstock ◽

Roland Schweizer

Keyword(s):

Energy Expenditure ◽

Short Stature ◽

Turner Syndrome ◽

Resting Energy Expenditure ◽

Bioelectrical Impedance ◽

Fat Free Mass ◽

Gh Treatment ◽

Age Related ◽

Resting Energy

AbstractBackground:Knowledge concerning energy metabolism in Turner syndrome (TS) is lacking. We compared the resting energy expenditure per fat-free mass (REE/FFM) in TS with other girls with short stature treated with growth hormone (GH) and age-related controls.Methods:We measured prospectively REE by spirometry under fasting conditions in the morning in 85 short prepubertal girls at the start of GH treatment. Diagnoses were TS (n=20), GH deficiency (GHD) (n=38) and small for gestational age (SGA) short stature (n=27). Additionally, 20 age-related controls were studied. Mean ages were 8.3 (TS), 7.1 (GHD), 6.9 (SGA) and 8.5 years (controls). Mean heights were −2.90 (TS), −3.32 (GHD), −3.69 (SGA) and −0.03 standard deviation scores (SDS) (controls). FFM was measured by bioelectrical impedance analysis (BIA).Results:At the start of GH girls with TS showed insignificantly higher REE per FFM (REE/FFM) (mean±SD; 65±9 kcal/kg×day) than did the other female patients (62±9 kcal/kg×day) (p>0.23). The healthy controls had significantly lower REE/FFM (35±4 kcal/kg×day) (p<0.001). Follow-up examination of the patients after 6 or 12 months revealed decreasing REE/FFM in TS (62±9 kcal/kg×day) resulting in comparable REE/FFM in all three patient groups.Conclusions:At baseline short girls with TS had insignificantly higher REE/FFM than short children with SGA or GHD, but in follow-up this difference was not detectable any more. Future studies are necessary to understand this observation.

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