Celiac Disease-Type Tissue Transglutaminase Autoantibody Deposits in Kidney Biopsies of Patients with IgA Nephropathy

An association between celiac disease and IgA nephropathy (IgAN) has been suggested. In celiac disease, in addition to circulating in serum, IgA-class tissue transglutaminase (tTG) autoantibodies are deposited in the small bowel mucosa and extraintestinal organs. In this case series of IgAN patients with or without celiac disease, we studied whether celiac disease-type IgA-tTG deposits occur in kidney biopsies. The study included nine IgAN patients, four of them with celiac disease. At the time of the diagnostic kidney biopsy serum tTG autoantibodies were measured and colocalization of IgA and tTG was investigated in the frozen kidney biopsies. Three IgAN patients with celiac disease had IgA-tTG deposits in the kidney even though in two of these the celiac disease diagnosis had been set years later. These deposits were not found in a patient with already diagnosed celiac disease following a gluten-free diet. Of the five non-celiac IgAN patients, three had IgA-tTG deposits in the kidney. We conclude that tTG-targeted IgA deposits can be found in the kidney biopsies of gluten-consuming IgAN patients but their specificity to celiac disease seems limited.

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Diagnosis of celiac disease in routine clinical practice

Pediatrician (St Petersburg) ◽

10.17816/ped5214-18 ◽

2014 ◽

Vol 5 (2) ◽

pp. 14-18 ◽

Cited By ~ 1

Author(s):

Lyubov Aleksandrovna Reshetnik ◽

Oksana Viktorovna Antsiferova ◽

Tatyana Anatolyevna Spasich ◽

Sergey Stepanovich Golubev

Keyword(s):

Celiac Disease ◽

Mucous Membrane ◽

Tissue Transglutaminase ◽

Disease Diagnosis ◽

Membrane Thickness ◽

Morphological Investigation ◽

Biopsy Material ◽

Selective Sampling ◽

Celiac Disease Diagnosis ◽

Endoscopic Investigation

During 10 years there has been conducted the purposeful clinical and laboratory investigation of 1775 children aged from 6 months to 18 years. In all patients antibodies to glyadin and tissue transglutaminase have been defined. 494 (27,83 %) children with positive serological markers have been send to endoscopic investigation with subsequent morphological investigation of biopsy material. In selective sampling of children the morphologically confirmed celiac disease is occurred with the frequency 1 to 40. Morphometric indices of duodenum mucous membrane are characterized with decrease of mucous membrane thickness, height of villi, ratio of villi height to depth of crypts. As a compensation crypts depth and a number of interepithelial lymphocytes are increased. Small changes correspond to manifest form of celiac disease. Probability of morphological confirmation of celiac disease diagnosis is higher in children to 7 years old.

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Tu1464 NEO-EPITOPE TISSUE TRANSGLUTAMINASE IS THE BEST AND NEO-EPITOPE MICROBIAL TRANSGLUTAMINASE IS A NEW BIOMARKERS FOR CELIAC DISEASE DIAGNOSIS

Gastroenterology ◽

10.1016/s0016-5085(20)33464-8 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-1117-S-1118

Author(s):

Torsten Matthias ◽

Sandra Neidhöfer ◽

Anette Heller ◽

Aaron Lerner

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Disease Diagnosis ◽

Microbial Transglutaminase ◽

Celiac Disease Diagnosis ◽

New Biomarkers

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Modern Aspects of Celiac Disease Diagnosis in Children

Вопросы современной педиатрии ◽

10.15690/vsp.v19i5.2217 ◽

2020 ◽

Vol 19 (5) ◽

pp. 371-378

Author(s):

Aelita A. Kamalova ◽

Daria O. Timofeeva ◽

Almazia R. Shakirova

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Clinical Manifestations ◽

Disease Diagnosis ◽

Upper Limit ◽

Immune Mediated ◽

Wide Range ◽

Systemic Disorder ◽

Antigen Tests ◽

Celiac Disease Diagnosis

Celiac disease is an immune-mediated systemic disorder caused by gluten in people with genetic predisposition. Celiac disease is characterized by wide range of clinical manifestations (both gastroenterological and extraintestinal), that can complicate the diagnosis. Thus, celiac disease often remains undiagnosed. ESPGHAN has published updated clinical guidelines with adjusted coeliac disease diagnosis algorithms in 2020. It is proposed to determine antibodies to tissue transglutaminase (TGA-IgA) and total IgA within normal content of gluten-containing products in the diet on the first stage of children screening. The diagnosis of celiac disease can be established without small intestine biopsy in case of increased levels of TGA-IgA ≥ 10 of upper limit of normal and presence of antibodies to endomysium (EMA-IgA) in secondary serum. In such cases, ESPGHAN does not recommend any additional genetic testing to confirm celiac disease as it does not increase the reliability of the diagnosis. Antigen tests on class G or A antibodies against native gliadin are not specific and are not recommended for use in the diagnosis of celiac disease.

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P61 Does celiac disease diagnosis modify the game rules in lupus patients? A 7 case series report

10.1136/lupus-2020-eurolupus.108 ◽

2020 ◽

Author(s):

Jorge Juan Fragío Gil ◽

Roxana González Mazarío ◽

José Ivorra Cortés ◽

Elena Grau-García ◽

Luis González-Puig ◽

...

Keyword(s):

Celiac Disease ◽

Case Series ◽

Disease Diagnosis ◽

Case Series Report ◽

Celiac Disease Diagnosis ◽

Series Report

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Australasian Pediatric Gastroenterologists’ Perspectives and Practices of Celiac Disease Diagnosis and Management

Digestive Diseases and Sciences ◽

10.1007/s10620-021-06988-2 ◽

2021 ◽

Author(s):

Shaun S. C. Ho ◽

Sophie Hall ◽

Jacqueline I. Keenan ◽

Andrew S. Day

Keyword(s):

Celiac Disease ◽

Disease Diagnosis ◽

Diagnosis And Management ◽

Celiac Disease Diagnosis

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LOW BONE MINERAL DENSITY IN BRAZILIAN PATIENTS AT DIAGNOSIS OF CELIAC DISEASE

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032015000300004 ◽

2015 ◽

Vol 52 (3) ◽

pp. 176-179 ◽

Cited By ~ 3

Author(s):

Joyce Timmermans Pires da SILVA ◽

Renato M NISIHARA ◽

Luís Roberto KOTZE ◽

Márcia OLANDOSKI ◽

Lorete Maria da Silva KOTZE

Keyword(s):

Bone Mineral Density ◽

Celiac Disease ◽

Bone Mineral ◽

Disease Diagnosis ◽

Bone Fragility ◽

Mineral Density ◽

X Ray ◽

Low Bone Mineral Density ◽

Celiac Disease Diagnosis ◽

Male Subjects

BackgroundLow bone mineral density is considered an extra-intestinal manifestation of celiac disease with reduced bone mass, increased bone fragility, and risk of fractures. Celiac disease is considered a condition at high risk for secondary osteoporosis and the evaluation of bone density is very important in the clinical management of these patients.ObjectiveThe present study aimed to investigate bone alterations in celiac patients from Curitiba, South Region of Brazil at diagnosis, correlating the findings with age and gender.MethodsPatients who were included in the study were attended to in a private office of the same physician from January 2009 to December 2013. The diagnosis of celiac disease was done through clinical, serological and histological findings. All data were collected from the medical charts of the patients. After the diagnosis of celiac disease, evaluation for low bone mineral density was requested by dual-energy X-ray absorptiometry (DEXA). DEXA bone densitometer was used to estimate low bone mineral density at the lumbar spine and femur.ResultsA total of 101 patients, 82 (81.2%) female and 19 (18.8%) male subjects, with mean age of 39.0±3.03 years were included. At celiac disease diagnosis, 36 (35.6%) were younger than 30 years, 41 (40.6%) were between 31 and 50 years, and 24 (23.8%) were older than 50 years. Among the evaluated patients, 69 (68.3%) presented low bone mineral density, being 47% with osteopenia and 32% with osteoporosis. Patients who were older than 51 years and diagnosed with celiac disease presented low bone mineral density in 83.3% (20/24) of the cases. As expected, age influenced significantly the low bone mineral density findings. Among women, low bone mineral density was present with high frequency (60%) from 30 to 50 years. In patients diagnosed older than 60 years (n=8), all the women (n=5) and two of the three men had osteoporosis.ConclusionThis study demonstrated that 69% of Brazilian patients with celiac disease at diagnosis had low bone mineral density, being more frequent in women older than 50 years.

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