scholarly journals Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2087
Author(s):  
Mizuki Ogawa ◽  
Miyako Udono ◽  
Kiichiro Teruya ◽  
Norihisa Uehara ◽  
Yoshinori Katakura
Keyword(s):  
Hair Follicle ◽  
Molecular Basis ◽  
Hair Growth ◽  
Growth Promotion ◽  
Hacat Cells ◽  
Hair Cycle ◽  
Hair Follicle Stem Cells ◽  
Novel Target ◽  
Cycle Regulation ◽  
Follicle Stem Cells

Enhanced telomerase reverse transcriptase (TERT) levels in dermal keratinocytes can serve as a novel target for hair growth promotion. Previously, we identified fisetin using a system for screening food components that can activate the TERT promoter in HaCaT cells (keratinocytes). In the present study, we aimed to clarify the molecular basis of fisetin-induced hair growth promotion in mice. To this end, the dorsal skin of mice was treated with fisetin, and hair growth was evaluated 12 days after treatment. Histochemical analyses of fisetin-treated skin samples and HaCaT cells were performed to observe the effects of fisetin. The results showed that fisetin activated HaCaT cells by regulating the expression of various genes related to epidermogenesis, cell proliferation, hair follicle regulation, and hair cycle regulation. In addition, fisetin induced the secretion of exosomes from HaCaT cells, which activated β-catenin and mitochondria in hair follicle stem cells (HFSCs) and induced their proliferation. Moreover, these results revealed the existence of exosomes as the molecular basis of keratinocyte-HFSC interaction and showed that fisetin, along with its effects on keratinocytes, caused exosome secretion, thereby activating HFSCs. This is the first study to show that keratinocyte-derived exosomes can activate HFSCs and consequently induce hair growth.

Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation.

1993 ◽  
Vol 101 (s1) ◽  
pp. 16S-26S ◽  
Author(s):  
Robert M. Lavker ◽  
Stanley Miller ◽  
Caroline Wilson ◽  
George Cotsarelis ◽  
Zhi-Gang Wei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Hair Cycle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice

2020 ◽  
Vol 39 (18) ◽  
Author(s):  
Guo Li ◽  
Xiaolong Tang ◽  
Shuping Zhang ◽  
Meiling Jin ◽  
Ming Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Hair Growth ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth

2016 ◽  
Vol 136 (8) ◽  
pp. 1549-1558 ◽  
Author(s):  
Andrew A. Smith ◽  
Jingtao Li ◽  
Bo Liu ◽  
Daniel Hunter ◽  
Malcolm Pyles ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Hair Growth ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Hair follicle stem cells: Their location, role in hair cycle, and involvement in skin tumor formation

1993 ◽  
Vol 101 (1) ◽  
pp. S16-S26 ◽  
Author(s):  
Robert M. Lavker ◽  
Stanley Miller ◽  
Caroline Wilson ◽  
George Cotsarelis ◽  
Zhi-Gang Wei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Hair Cycle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

2016 ◽  
Vol 136 (11) ◽  
pp. 2140-2149 ◽  
Author(s):  
Nicole Amberg ◽  
Martin Holcmann ◽  
Gabriel Stulnig ◽  
Maria Sibilia
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Hair Cycle ◽  
Cycle Progression ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Lgr4 Deletion Delays the Hair Cycle and Inhibits the Activation of Hair Follicle Stem Cells

2020 ◽  
Vol 140 (9) ◽  
pp. 1706-1712.e4 ◽  
Author(s):  
Xiaolin Ren ◽  
Weili Xia ◽  
Peng Xu ◽  
Hongyang Shen ◽  
Xing Dai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Hair Cycle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

Mouse Skin Is Particularly Susceptible to Tumor Initiation During Early Anagen of the Hair Cycle: Possible Involvement of Hair Follicle Stem Cells

1993 ◽  
Vol 101 (4) ◽  
pp. 591-594 ◽  
Author(s):  
Stanley J Miller ◽  
Zhi-Gang Wei ◽  
Caroline Wilson ◽  
Leonard Dzubow ◽  
Tung-Tien Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Mouse Skin ◽  
Tumor Initiation ◽  
Hair Cycle ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells

scholarly journals Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Kefei Nina Li ◽  
Prachi Jain ◽  
Catherine Hua He ◽  
Flora Chae Eun ◽  
Sangjo Kang ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Cell Activation ◽  
Adult Mouse ◽  
Tissue Homeostasis ◽  
Hair Cycle ◽  
Delayed Entry ◽  
Adult Mice ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells ◽  
Adult Skin

Skin vasculature cross-talking with hair follicle stem cells (HFSCs) is poorly understood. Skin vasculature undergoes dramatic remodeling during adult mouse hair cycle. Specifically, a horizontal plexus under the secondary hair germ (HPuHG) transiently neighbors the HFSC activation zone during the quiescence phase (telogen). Increased density of HPuHG can be induced by reciprocal mutations in the epithelium (Runx1) and endothelium (Alk1) in adult mice, and is accompanied by prolonged HFSC quiescence and by delayed entry and progression into the hair growth phase (anagen). Suggestively, skin vasculature produces BMP4, a well-established HFSC quiescence-inducing factor, thus contributing to a proliferation-inhibitory environment near the HFSC. Conversely, the HFSC activator Runx1 regulates secreted proteins with previously demonstrated roles in vasculature remodeling. We suggest a working model in which coordinated remodeling and molecular cross-talking of the adult epithelial and endothelial skin compartments modulate timing of HFSC activation from quiescence for proper tissue homeostasis of adult skin.

scholarly journals Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0232206
Author(s):  
Jung-Min Shin ◽  
Jung-Woo Ko ◽  
Chong-Won Choi ◽  
Young Lee ◽  
Young-Joon Seo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Hair Growth ◽  
Growth Cycle ◽  
Adult Mice ◽  
Hair Follicle Stem Cells ◽  
Follicle Stem Cells
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