scholarly journals APELA Expression in Glioma, and Its Association with Patient Survival and Tumor Grade

2019 ◽  
Vol 12 (1) ◽  
pp. 45 ◽  
Author(s):  
Debolina Ganguly ◽  
Chun Cai ◽  
Michelle Sims ◽  
Chuan Yang ◽  
Matthew Thomas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Tumor ◽  
Patient Survival ◽  
Receptor Gene ◽  
Embryonic Stem ◽  
Tumor Grade ◽  
Adult Brain ◽  
Tumor Initiating Cells ◽  
Apelin Receptor ◽  
Cell Niche

Glioblastoma (GBM) is the most common and deadliest primary adult brain tumor. Invasion, resistance to therapy, and tumor recurrence in GBM can be attributed in part to brain tumor-initiating cells (BTICs). BTICs isolated from various patient-derived xenografts showed high expression of the poorly characterized Apelin early ligand A (APELA) gene. Although originally considered to be a non-coding gene, the APELA gene encodes a protein that binds to the Apelin receptor and promotes the growth of human embryonic stem cells and the formation of the embryonic vasculature. We found that both APELA mRNA and protein are expressed at high levels in a subset of brain tumor patients, and that APELA is also expressed in putative stem cell niche in GBM tumor tissue. Analysis of APELA and the Apelin receptor gene expression in brain tumor datasets showed that high APELA expression was associated with poor patient survival in both glioma and glioblastoma, and APELA expression correlated with glioma grade. In contrast, gene expression of the Apelin receptor or Apelin was not found to be associated with patient survival, or glioma grade. Consequently, APELA may play an important role in glioblastoma tumorigenesis and may be a future therapeutic target.

scholarly journals GATA-1 Dominantly Activates a Program of Erythroid Gene Expression in Factor-Dependent Myeloid FDCW2 Cells

1998 ◽  
Vol 18 (6) ◽  
pp. 3278-3288 ◽  
Author(s):  
Dhaya Seshasayee ◽  
Peter Gaines ◽  
Don M. Wojchowski
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Cell Cycle Progression ◽  
Receptor Gene ◽  
Globin Gene ◽  
Gene Activation ◽  
Embryonic Stem ◽  
Lineage Specification ◽  
Epo Receptor ◽  
Receptor Gene Expression

ABSTRACT Erythrocyte development has previously been shown to depend upon the expression of the lineage-restricted trans-acting factor GATA-1. Despite predicted roles for this factor during early development, GATA-1-deficient cells in chimeric mice and embryonic stem cell cultures mature to a late proerythroblast stage and express at least certain genes that normally are thought to be regulated by GATA-1 (including erythroid Krüppel-like factor [EKLF] and the erythropoietin [Epo] receptor). Opportunities to test roles for GATA-1 in erythroid gene activation in these systems therefore are limited. In the present study, in an alternate approach to test the function of GATA-1, GATA-1 has been expressed together with the Epo receptor in myeloid FDCW2 cells and the resulting effects on cytokine-dependent proliferation and erythroid gene expression have been assessed. GATA-1 expression at low levels delayed FDCW2ER cell cycle progression at the G1 phase specifically during Epo-induced mitogenesis. Upon expression of GATA-1 at increased levels, proliferation in response to Epo, interleukin-3 (IL-3), and stem cell factor was attenuated and endogenous GATA-1, EKLF and βmaj-globin gene expression was activated. Friend of GATA-1 (FOG) transcript levels also were enhanced, andets-1 and c-mpl but not Epo receptor gene expression was induced. Finally, in FDCW2 cells expressing increased levels of GATA-1 and a carboxyl-terminally truncated Epo receptor, Epo (with respect to IL-3 as a control) was shown to markedly promote globin transcript expression. Thus, novel evidence for select hierarchical roles for GATA-1 and Epo in erythroid lineage specification is provided.

scholarly journals Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

1991 ◽  
Vol 5 (5) ◽  
pp. 728-740 ◽  
Author(s):  
R M Schmitt ◽  
E Bruyns ◽  
H R Snodgrass
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Receptor Gene ◽  
Embryonic Stem ◽  
Hematopoietic Development ◽  
Receptor Gene Expression

scholarly journals Increased apelin receptor gene expression in the subfornical organ of spontaneously hypertensive rats

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231844
Author(s):  
Philip R. Griffiths ◽  
Stephen J. Lolait ◽  
Aarifah Bijabhai ◽  
Aoife O’Carroll-Lolait ◽  
Julian F. R. Paton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spontaneously Hypertensive Rats ◽  
Receptor Gene ◽  
Subfornical Organ ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Apelin Receptor ◽  
Receptor Gene Expression

scholarly journals Differentiation of murine embryonic stem cells induces progesterone receptor gene expression

2005 ◽  
Vol 311 (2) ◽  
pp. 251-264 ◽  
Author(s):  
Carley N. Sauter ◽  
Rebecca L. McDermid ◽  
Amy L. Weinberg ◽  
Tamara L. Greco ◽  
Xiaojie Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Progesterone Receptor ◽  
Receptor Gene ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Progesterone Receptor Gene ◽  
Receptor Gene Expression

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression

VIRAL RECEPTOR GENE EXPRESSION AND MYOCARDITIS DEVELOPMENT

2016 ◽  
Vol 30 (1) ◽  
Author(s):  
A. Runov ◽  
◽  
E Kurchakova ◽  
D Khaschevskaya ◽  
O Moiseeva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Receptor Gene ◽  
Viral Receptor ◽  
Receptor Gene Expression
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