scholarly journals Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1120 ◽  
Author(s):  
Shuo Huang ◽  
Xin Wei ◽  
Mingfeng Wang
Keyword(s):  
Block Copolymers ◽  
Drug Loading ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Intracellular Release ◽  
Transmission Electron ◽  
Amorphous Block ◽  
Covalently Bonded ◽  
Imaging Probes ◽  
Self Assembled

We report a red-fluorescent drug delivery system formed by biodegradable and biocompatible amphiphilic A-B-A block copolymers. Each polymer consists of a red fluorescent dye covalently bonded in the middle of hydrophobic block (B) of polylactone, tethered at both ends with poly[(oligo ethylene glycol) methyl ether methacrylate] (POEGMA) as the hydrophilic block. Two types of polylactones, i.e., semicrystalline poly(ε-caprolactone) (PCL) and amorphous poly(δ-decalactone) (PDL), respectively, were incorporated as the hydrophobic segment in the block copolymers. Using transmission electron microscopy, we characterized the self-assembled nanostructures formed by these amphiphilic block copolymers in mixtures of water/tetrahydrofuran or water/dimethylformamide. All of these polymers remained highly fluorescent in water, although some extent of aggregation-induced fluorescence quenching was still observed. Among the three types of polymers presented here, the polymer (RPO-3) containing an amorphous block of PDL showed the highest drug-loading capacity and the largest extent of drug release in acidic media. RPO-3 micelles loaded with doxorubicin as a model of anticancer drug showed sustainable intracellular release and cytotoxicity against HeLa cells.

scholarly journals Tuning the hydrophobic cores of self-immolative polyglyoxylate assemblies

2018 ◽  
Vol 9 (19) ◽  
pp. 2601-2610 ◽  
Author(s):  
Bo Fan ◽  
Rebecca E. Yardley ◽  
John F. Trant ◽  
Aneta Borecki ◽  
Elizabeth R. Gillies
Keyword(s):  
Block Copolymers ◽  
Drug Carriers ◽  
Amphiphilic Block Copolymers ◽  
Release Rates ◽  
Self Assembled ◽  
Hydrophobic Cores

Amphiphilic block copolymers containing different self-immolative polyglyoxylates were synthesized and self-assembled to provide drug carriers with variable celecoxib loading capacities and release rates, as well as different in vitro toxicities.

Slowing the translocation of single-stranded DNA by using nano-cylindrical passage self-assembled by amphiphilic block copolymers

Nanoscale ◽  
2016 ◽  
Vol 8 (43) ◽  
pp. 18270-18276 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Yusuke Goto ◽  
Rena Akahori ◽  
Yasuhiko Tada ◽  
Shohei Terada ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Single Stranded Dna ◽  
Self Assembled

scholarly journals Structural hierarchy in blends of amphiphilic block copolymers self-assembled at the air-water interface

2019 ◽  
Vol 556 ◽  
pp. 392-400 ◽  
Author(s):  
Janet Hood ◽  
Kyle Van Gordon ◽  
Patricia Thomson ◽  
Brian R. Coleman ◽  
Fraser Burns ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Water Interface ◽  
Structural Hierarchy ◽  
Air Water Interface ◽  
Self Assembled

Phase separation and self-assembly of cyclic amphiphilic block copolymers with a main-chain liquid crystalline segment

2015 ◽  
Vol 6 (22) ◽  
pp. 4167-4176 ◽  
Author(s):  
Satoshi Honda ◽  
Maito Koga ◽  
Masatoshi Tokita ◽  
Takuya Yamamoto ◽  
Yasuyuki Tezuka
Keyword(s):  
Phase Separation ◽  
Solid State ◽  
Block Copolymers ◽  
Electric Field ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Main Chain ◽  
Amphiphilic Block Copolymers ◽  
Cylindrical Micelles ◽  
Self Assembled

The effects of the macrocyclization of amphiphiles with a liquid crystalline segment were investigated in the solid state, and electric field-responsive cylindrical micelles and vesicles were self-assembled.

Functionalization of Magnetic Nanoparticles with Amphiphilic Block Copolymers: Self-Assembled Thermoresponsive Submicrometer Particles

Langmuir ◽  
2012 ◽  
Vol 28 (9) ◽  
pp. 4142-4151 ◽  
Author(s):  
Angela M. Budgin ◽  
Yuri A. Kabachii ◽  
Zinaida B. Shifrina ◽  
Pyotr M. Valetsky ◽  
Sergey S. Kochev ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Self Assembled

Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs

2019 ◽  
Vol 7 (2) ◽  
pp. 286-295 ◽  
Author(s):  
Yinlu Deng ◽  
Hua Yuan ◽  
Weizhong Yuan
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Anticancer Drugs ◽  
Amphiphilic Block Copolymers ◽  
Hypoxic Conditions ◽  
Copolymer Micelles ◽  
Self Assembled

Hypoxia-responsive PEG-b-P(MAA-co-NIMA) copolymer micelles expanded under hypoxic conditions and achieved the controlled release of anticancer DOX molecules.

Radio-opaque Micelles for X-ray Imaging

2014 ◽  
Vol 67 (1) ◽  
pp. 78 ◽  
Author(s):  
Zhiyong Wang ◽  
Teddy Chang ◽  
Luke Hunter ◽  
Andrew M. Gregory ◽  
Marcel Tanudji ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Block Size ◽  
Drug Carriers ◽  
Block Copolymerization ◽  
X Ray ◽  
Transmission Electron ◽  
X Ray Imaging ◽  
Reversible Addition ◽  
Rate Of Polymerization

Block copolymers based on iodinated monomers were prepared with the aim of creating nanoparticles as contrast agents suitable for X-ray imaging. Reversible addition–fragmentation chain-transfer polymerization was employed to synthesize block copolymers based on oligo(ethylene glycol) methylether methacrylate (OEGMEMA) and 2-[2′,3′,5′-triiodobenzoyl]oxyethyl methacrylate (METB). The polymerization of METB was found to be slow owing to the low solubility of the monomer, which does not allow high enough concentration to achieve a fast rate of polymerization. However, the block copolymerization was well controlled, resulting in several block copolymers, POEGMEMA-b-PMETB, which were further investigated in regards to their self-assembly in water. Micelles were prepared using POEGMEMA55-b-PMETB18, POEGMEMA55-b-PMETB32, POEGMEMA100-b-PMETB22, and POEGMEMA100-b-PMETB32. Transmission electron microscopy and dynamic light scattering revealed micelle sizes between 30 and 45 nm depending on the block size. The micelles were found to show a strong contrast similar to BaSO4 and Visipaque (iodixanol) during X-ray analysis. These micelles can now further be employed as drug carriers or can be conjugated to a bioactive group for targeting.

Drug Deliverable, Self-assembled Rosette Nanotubes (RNTs) for Orthopedic Applications

2009 ◽  
Vol 1209 ◽  
Author(s):  
Yupeng Chen ◽  
Shang Song ◽  
Hicham Fenniri ◽  
Thomas J Webster
Keyword(s):  
Drug Delivery ◽  
Bone Growth ◽  
Hydrophobic Interactions ◽  
Positive Impact ◽  
Drug Loading ◽  
Drug Carriers ◽  
Rosette Nanotubes ◽  
Cellular Environment ◽  
Self Assembled ◽  
Orthopedic Applications

AbstractRosette nanotubes (RNTs) are novel, biomimetic, synthetic, self-assembled drug delivery agents. Because of base stacking and hydrophobic interactions, the RNT hollow-tube structure can be used for incorporating drugs. Another advantage of using RNTs is their ability to be injected and become solid at body temperatures for orthopedic applications without the use of any external stimuli (such as UV light or crosslinking agents). The nano-features of RNTs create a favorable, biologically-inspired, cellular environment. In this study, methods to incorporate dexamethasone (DEX, a bone growth promoting drug) into RNTs were investigated. The drug-loaded RNTs were characterized using Nuclear Magnetic Resonance (NMR), Diffusion Ordered Spectroscopy (DOSY) and Ultraviolet-visible Spectroscopy (UV-vis). Results showed that small molecular drugs with hydrophobic aromatic rings were incorporated into RNTs. Subsequent drug release experiments demonstrated that DEX was released from the RNTs and had a positive impact on osteoblast functions. Importantly, compared to other drug carriers, RNTs increased the total drug loading and was the highest when DEX was incorporated during the RNT self-assembly process. Thus, this study offered a novel drug delivery device that itself is bioactive and can be used to deliver a variety of drugs for various orthopedic applications.

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