Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications

Daniel-Cristian Ioan; Ileana Rău; Mădălina Georgiana Albu Kaya; Nicoleta Radu; Marinela Bostan; Roxana Gabriela Zgârian; Graţiela Teodora Tihan; Cristina-Elena Dinu-Pîrvu; Alina Lupuliasa; Mihaela Violeta Ghica

doi:10.3390/polym12091915

Ciprofloxacin-Collagen-Based Materials with Potential Oral Surgical Applications

Polymers ◽

10.3390/polym12091915 ◽

2020 ◽

Vol 12 (9) ◽

pp. 1915

Author(s):

Daniel-Cristian Ioan ◽

Ileana Rău ◽

Mădălina Georgiana Albu Kaya ◽

Nicoleta Radu ◽

Marinela Bostan ◽

...

Keyword(s):

Drug Release ◽

Cytotoxic Drug ◽

Synthesis And Characterization ◽

In Vitro Tests

We report in this paper the synthesis and characterization of a new collagen-based material. This material was obtained in a spongy form and was functionalized with an antibiotic, ciprofloxacin. The targeted applications of these kind of materials concern the post-operative prophylaxis. The in vitro tests (antimicrobial, cytotoxic, drug release) showed that sponges with a concentration of 0.75 g of ciprofloxacin per gram of collagen could be beneficial for the desired applications.

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Synthesis and characterization of semi-conductive nanocomposite based on hydrolyzed collagen and in vitro electrically controlled drug release study

Polymer ◽

10.1016/j.polymer.2015.06.050 ◽

2015 ◽

Vol 76 ◽

pp. 287-294 ◽

Cited By ~ 14

Author(s):

Ali Pourjavadi ◽

Mohadeseh Doroudian

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Synthesis And Characterization ◽

Drug Release Study ◽

Hydrolyzed Collagen ◽

Release Study

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Synthesis and Characterization of Chrysin-Loaded β-Cyclodextrin-Based Nanosponges to Enhance In-Vitro Solubility, Photostability, Drug Release, Antioxidant Effects and Antitumorous Efficacy

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2017.13911 ◽

2017 ◽

Vol 17 (12) ◽

pp. 8742-8751 ◽

Cited By ~ 5

Author(s):

Mahalingam Sundararajan ◽

Philip A Thomas ◽

Karuppasamy Venkadeswaran ◽

Kulandaivel Jeganathan ◽

Pitchairaj Geraldine

Keyword(s):

Drug Release ◽

Synthesis And Characterization ◽

Antioxidant Effects

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Development, Optimization and Characterization of Eudraguard®-Based Microparticles for Colon Delivery

Pharmaceuticals ◽

10.3390/ph13060131 ◽

2020 ◽

Vol 13 (6) ◽

pp. 131

Author(s):

Claudia Curcio ◽

Antonio S. Greco ◽

Salvatore Rizzo ◽

Lorena Saitta ◽

Teresa Musumeci ◽

...

Keyword(s):

Drug Release ◽

In Vitro Release ◽

Chemical Properties ◽

In Vitro Tests ◽

Prolonged Release ◽

Scanning Calorimetry ◽

Colon Delivery ◽

Ph Dependent

Development of pH-dependent systems for colon delivery of natural active ingredients is an attractive area of research in the field of nutraceutical products. This study was focused on Eudraguard® resins, that are methacrylate copolymers approved as “food grade” by European Commission and useful for the production of food supplements. In particular, Eudraguard® Biotic (EUG-B), characterized by a pH-dependent solubility and Eudraguard® Control (EUG-C), whose chemical properties support a prolonged release of the encapsulated compounds, were tested. To obtain EUG microparticles, different preparation techniques were tested, in order to optimize the preparation method and observe the effect upon drug encapsulation and specific colonic release. Unloaded microparticles were initially produced to evaluate the influence of polymer characteristics on the formulation process; subsequently microparticles loaded with quercetin (QUE) as a low solubility model drug were prepared. The characterization of microparticles in the solid-state (FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry) indicated that QUE was uniformly dispersed in a non-crystalline state in the polymeric network, without strong signs of chemical interactions. Finally, to assess the ability of EUG-C and EUG-B to control the drug release in the gastric environment, and to allow an increased release at a colonic level, suitable in vitro release tests were carried out by simulating the pH variations along the gastro-intestinal tract. Among the evaluated preparation methods, those in which an aqueous phase was not present, and in particular the emulsion-solvent evaporation method produced the best microparticle systems. The in vitro tests showed a limited drug release at a gastric level and a good specific colon release.

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