scholarly journals Carbonate Apatite Nanoparticles-Facilitated Intracellular Delivery of siRNA(s) Targeting Calcium Ion Channels Efficiently Kills Breast Cancer Cells

Toxics ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 34 ◽  
Author(s):  
Mohammad Uddin ◽  
Balakavitha Balaravi Pillai ◽  
Kyi Tha ◽  
Maeirah Ashaie ◽  
Md. Karim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ion Channels ◽  
Cancer Cells ◽  
Calcium Ion ◽  
Breast Cancer Cells ◽  
Intracellular Delivery ◽  
Carbonate Apatite ◽  
Calcium Ion Channels

Targeted Intracellular Delivery of Trastuzumab Using Designer Phage Lambda Nanoparticles Alters Cellular Programs in Human Breast Cancer Cells

ACS Nano ◽  
2021 ◽  
Author(s):  
Alexis Catala ◽  
Monika Dzieciatkowska ◽  
Guankui Wang ◽  
Arthur Gutierrez-Hartmann ◽  
Dmitri Simberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Intracellular Delivery ◽  
Human Breast Cancer Cells ◽  
Phage Lambda ◽  
Human Breast

Engineered Histidine-Enriched Facial Lipopeptides for Enhanced Intracellular Delivery of Functional siRNA to Triple Negative Breast Cancer Cells

2019 ◽  
Vol 11 (5) ◽  
pp. 4719-4736 ◽  
Author(s):  
Abhijit Biswas ◽  
Kasturee Chakraborty ◽  
Chiranjit Dutta ◽  
Sanchita Mukherjee ◽  
Paramita Gayen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Intracellular Delivery

scholarly journals Mechano-Sensitive Ion Channels (MSCS) Provide Human Breast Cancer Cells with a Sensorium for Mechanical Stress

2014 ◽  
Vol 106 (2) ◽  
pp. 549a-550a
Author(s):  
Chouyang Li ◽  
Simin Rezania ◽  
Sarah Kammerer ◽  
Astrid Gorischek ◽  
Thomas Bauernhofer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ion Channels ◽  
Cancer Cells ◽  
Mechanical Stress ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Intracellular Delivery of siRNAs Targeting AKT and ERBB2 Genes Enhances Chemosensitization of Breast Cancer Cells in a Culture and Animal Model

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 458 ◽  
Author(s):  
Tahereh Fatemian ◽  
Hamid Reza Moghimi ◽  
Ezharul Hoque Chowdhury
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Pharmacokinetic Profile ◽  
Carbonate Apatite ◽  
Delivery Device ◽  
Synergistic Interactions ◽  
Anti Cancer ◽  
4T1 Cells

Pharmacotherapy as the mainstay in the management of breast cancer suffers from various drawbacks, including non-targeted biodistribution, narrow therapeutic and safety windows, and also resistance to treatment. Thus, alleviation of the constraints from the pharmacodynamic and pharmacokinetic profile of classical anti-cancer drugs could lead to improvements in efficacy and patient survival in malignancies. Moreover, modifications in the genetic pathophysiology of cancer via administration of small nucleic acids might pave the way towards higher response rates to chemotherapeutics. Inorganic pH-dependent carbonate apatite (CA) nanoparticles were utilized in this study to efficiently deliver various classes of therapeutics into cancer cells. Co-delivery of drugs and genetic materials was successfully attained through a carbonate apatite delivery device. On 4T1 cells, siRNAs against AKT and ERBB2 plus paclitaxel or docetaxel resulted in the largest increase in anti-cancer effects compared to CA/paclitaxel or CA/docetaxel. Therefore, these ingredients were selected for further in vivo investigations. Animals receiving injections of CA/paclitaxel or CA/docetaxel loaded with siRNAs against AKT and ERBB2 possessed significantly smaller tumors compared to CA/drug-treated mice. Interestingly, synergistic interactions in target protein knock down with combinations of CA/AKT/paclitaxel, CA/ERBB2/docetaxel were documented via western blotting.

Targeted phase-change contrast agents for intracellular delivery to breast cancer tumors: An In vitro study in MDA-MB-231 breast cancer cells

2016 ◽  
Vol 140 (4) ◽  
pp. 3371-3371
Author(s):  
Kyle P. Hadinger ◽  
Joseph P. Marshalek ◽  
Paul S. Sheeran ◽  
Pier Ingram ◽  
Russell S. Witte ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Phase Change ◽  
Contrast Agents ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
In Vitro Study ◽  
Intracellular Delivery ◽  
Vitro Study
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