scholarly journals Hantavirus Research in Finland: Highlights and Perspectives

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1452
Author(s):  
Antti Vaheri ◽  
Heikki Henttonen ◽  
Jukka Mustonen
Keyword(s):  
Boreal Forests ◽  
Myodes Glareolus ◽  
Mild Disease ◽  
Bank Voles ◽  
History Of ◽  
Temperate Europe ◽  
Cyclic Dynamics ◽  
Diagnostic Research ◽  
Bank Vole Myodes Glareolus

Finland has the highest incidence of hantavirus infections globally, with a significant impact on public health. The large coverage of boreal forests and the cyclic dynamics of the dominant forest rodent species, the bank vole Myodes glareolus, explain most of this. We review the relationships between Puumala hantavirus (PUUV), its host rodent, and the hantavirus disease, nephropathia epidemica (NE), in Finland. We describe the history of NE and its diagnostic research in Finland, the seasonal and multiannual cyclic dynamics of PUUV in bank voles impacting human epidemiology, and we compare our northern epidemiological patterns with those in temperate Europe. The long survival of PUUV outside the host and the life-long shedding of PUUV by the bank voles are highlighted. In humans, the infection has unique features in pathobiology but rarely long-term consequences. NE is affected by specific host genetics and risk behavior (smoking), and certain biomarkers can predict the outcome. Unlike many other hantaviruses, PUUV causes a relatively mild disease and is rarely fatal. Reinfections do not exist. Antiviral therapy is complicated by the fact that when symptoms appear, the patient already has a generalized infection. Blocking vascular leakage measures counteracting pathobiology, offer a real therapeutic approach.

scholarly journals Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus

Open Biology ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. 170135 ◽  
Author(s):  
Grace M. Loxley ◽  
Jennifer Unsworth ◽  
Michael J. Turton ◽  
Alexandra Jebb ◽  
Kathryn S. Lilley ◽  
...  
Keyword(s):  
Bank Vole ◽  
Disulfide Bonds ◽  
Scent Marking ◽  
Myodes Glareolus ◽  
Sexually Dimorphic ◽  
Odorant Binding Proteins ◽  
Bank Voles ◽  
Odorant Binding ◽  
Bank Vole Myodes Glareolus ◽  
Novel Protein

The urine of bank voles ( Myodes glareolus ) contains substantial quantities of a small protein that is expressed at much higher levels in males than females, and at higher levels in males in the breeding season. This protein was purified and completely sequenced at the protein level by mass spectrometry. Leucine/isoleucine ambiguity was completely resolved by metabolic labelling, monitoring the incorporation of dietary deuterated leucine into specific sites in the protein. The predicted mass of the sequenced protein was exactly consonant with the mass of the protein measured in bank vole urine samples, correcting for the formation of two disulfide bonds. The sequence of the protein revealed that it was a lipocalin related to aphrodisin and other odorant-binding proteins (OBPs), but differed from all OBPs previously described. The pattern of secretion in urine used for scent marking by male bank voles, and the similarity to other lipocalins used as chemical signals in rodents, suggest that this protein plays a role in male sexual and/or competitive communication. We propose the name glareosin for this novel protein to reflect the origin of the protein and to emphasize the distinction from known OBPs.

scholarly journals Discovery of the bank vole (Myodes glareolus) on Ushant Island (Brittany, France)

Mammalia ◽  
2019 ◽  
Vol 83 (5) ◽  
pp. 496-500
Author(s):  
Olivier Lorvelec ◽  
Pascal Rolland ◽  
Patricia Le Quilliec ◽  
François Quénot ◽  
Alain Butet
Keyword(s):  
Small Mammal ◽  
Bank Vole ◽  
Ecological Monitoring ◽  
Barn Owl ◽  
Myodes Glareolus ◽  
Term Basis ◽  
Suitable Habitats ◽  
Bank Vole Myodes Glareolus ◽  
Owl Pellets

Abstract Ecological monitoring of small mammal occurrence on Ushant Island (Brittany, France) revealed the presence of the bank vole (Myodes glareolus) in September 2017. This was the first report of the bank vole on the island. Evaluation of previous small mammal monitoring and analysis of several batches of barn owl pellets allowed us to conclude that the arrival on the island is recent, sometime between 1995 and 2017. Further study is necessary to determine whether the current population, still incompletely distributed into suitable habitats of the island, will be self-sustaining on a long-term basis.

scholarly journals Evolutionary history of the bank vole Myodes glareolus: a morphometric perspective

2010 ◽  
Vol 100 (3) ◽  
pp. 681-694 ◽  
Author(s):  
RONAN LEDEVIN ◽  
JOHAN R. MICHAUX ◽  
VALÉRIE DEFFONTAINE ◽  
HEIKKI HENTTONEN ◽  
SABRINA RENAUD
Keyword(s):  
Bank Vole ◽  
Evolutionary History ◽  
Myodes Glareolus ◽  
History Of ◽  
Bank Vole Myodes Glareolus

scholarly journals Long-Term Spatiotemporal Stability and Dynamic Changes in the Haemoparasite Community of Bank Voles (Myodes glareolus) in NE Poland

2014 ◽  
Vol 68 (2) ◽  
pp. 196-211 ◽  
Author(s):  
Anna Bajer ◽  
Renata Welc-Falęciak ◽  
Małgorzata Bednarska ◽  
Mohammed Alsarraf ◽  
Jolanta Behnke-Borowczyk ◽  
...  
Keyword(s):  
Myodes Glareolus ◽  
Dynamic Changes ◽  
Ne Poland ◽  
Bank Voles

scholarly journals Seroprevalence of Trichinella spp. infection in bank voles (Myodes glareolus) – A long term study

2019 ◽  
Vol 9 ◽  
pp. 144-148 ◽  
Author(s):  
Maciej Grzybek ◽  
Aleksandra Cybulska ◽  
Katarzyna Tołkacz ◽  
Mohammed Alsarraf ◽  
Jolanta Behnke-Borowczyk ◽  
...  
Keyword(s):  
Myodes Glareolus ◽  
Term Study ◽  
Bank Voles ◽  
Long Term Study

Long-term presence of tick-borne encephalitis virus in experimentally infected bank voles (Myodes glareolus)

2021 ◽  
Vol 12 (4) ◽  
pp. 101693
Author(s):  
Anna Michelitsch ◽  
Christine Fast ◽  
Franziska Sick ◽  
Birke Andrea Tews ◽  
Karin Stiasny ◽  
...  
Keyword(s):  
Encephalitis Virus ◽  
Myodes Glareolus ◽  
Bank Voles ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Orally Administered Melatonin and the Accumulation and Toxicity of Cadmium in the Bank Vole (Myodes Glareolus)

2011 ◽  
Vol 56 (1-4) ◽  
pp. 19-33
Author(s):  
Ewa Chwełatiuk ◽  
Tadeusz Włostowski
Keyword(s):  
Bank Vole ◽  
Young Female ◽  
Myodes Glareolus ◽  
Cd Accumulation ◽  
Metal Chelator ◽  
Bank Voles ◽  
Gender And Age ◽  
Contaminated Food ◽  
Old Females ◽  
Bank Vole Myodes Glareolus

Orally Administered Melatonin and the Accumulation and Toxicity of Cadmium in the Bank Vole (Myodes Glareolus)Animal gender and age significantly influence the accumulation and toxicity of heavy metals, including cadmium (Cd). The aim of this study was to determine the effect of orally administered melatonin (6 μg/ml), a known antioxidant and metal chelator, on Cd accumulation and toxicity in one month old females and males (young) and five months old bank voles (old) exposed to dietary Cd (100 μg/g) for six weeks. Compared to the Cd alone group, melatonin co-treatment brought about a decrease of Cd concentration in the liver (17% and 20%) and kidneys (39% and 36%) of young female and male bank voles, respectively, while in old animals increased Cd accumulation in liver (65%) and kidneys (81%) and enhanced consumption of Cd-contaminated food (136%) without any effect on their body mass. The results suggest that orally administered melatonin together with cadmium in young bank voles reduces tissue Cd accumulation possibly through forming stable complexes with this metal but in older rodents, melatonin increases concentration of the metal through increasing consumption of Cd-contaminated food.

scholarly journals Long-term spatiotemporal stability and dynamic changes in helminth infracommunities of bank voles (Myodes glareolus) in NE Poland

Parasitology ◽  
2015 ◽  
Vol 142 (14) ◽  
pp. 1722-1743 ◽  
Author(s):  
MACIEJ GRZYBEK ◽  
ANNA BAJER ◽  
MAŁGORZATA BEDNARSKA ◽  
MOHAMMED AL-SARRAF ◽  
JOLANTA BEHNKE-BOROWCZYK ◽  
...  
Keyword(s):  
Rank Order ◽  
Myodes Glareolus ◽  
Spatial Effects ◽  
Dynamic Changes ◽  
Ne Poland ◽  
Bank Voles ◽  
Temporal And Spatial ◽  
Host Evolution ◽  
Host Parasite

SUMMARYParasites are considered to be an important selective force in host evolution but ecological studies of host-parasite systems are usually short-term providing only snap-shots of what may be dynamic systems. We have conducted four surveys of helminths of bank voles at three ecologically similar woodland sites in NE Poland, spaced over a period of 11 years, to assess the relative importance of temporal and spatial effects on helminth infracommunities. Some measures of infracommunity structure maintained relative stability: the rank order of prevalence and abundance ofHeligmosomum mixtum, Heligmosomoides glareoliandMastophorus murischanged little between the four surveys. Other measures changed markedly: dynamic changes were evident inSyphacia petrusewicziwhich declined to local extinction, while the capillariidAonchotheca annulosafirst appeared in 2002 and then increased in prevalence and abundance over the remaining three surveys. Some species are therefore dynamic and both introductions and extinctions can be expected in ecological time. At higher taxonomic levels and for derived measures, year and host-age effects and their interactions with site are important. Our surveys emphasize that the site of capture is the major determinant of the species contributing to helminth community structure, providing some predictability in these systems.

Screening for haemorrhagic disorders in paediatric patients by means of a questionnaire

2009 ◽  
Vol 29 (S 01) ◽  
pp. S87-S89 ◽  
Author(s):  
I. Music ◽  
M. Novak ◽  
B. Acham-Roschitz ◽  
W. Muntean
Keyword(s):  
Predictive Value ◽  
Laboratory Diagnosis ◽  
Von Willebrand Disease ◽  
Control Group ◽  
Older Children ◽  
Mild Disease ◽  
History Of ◽  
Von Willebrand ◽  
Specific Symptoms ◽  
Infants And Young Children

SummaryAim: In children, screening for haemorrhagic disorders is further complicated by the fact that infants and young children with mild disease in many cases most likely will not have a significant history of easy bruising or bleeding making the efficacy of a questionnaire even more questionable. Patients, methods: We compared the questionnaires of a group of 88 children in whom a haemorrhagic disorder was ruled out by rigorous laboratory investigation to a group of 38 children with mild von Willebrand disease (VWD). Questionnaires about child, mother and father were obtained prior to the laboratory diagnosis on the occasion of routine preoperative screening. Results: 23/38 children with mild VWD showed at least one positive question in the questionnaire, while 21/88 without laboratory signs showed at least one positive question. There was a trend to more specific symptoms in older children. Three or more positive questions were found only in VWD patients, but only in a few of the control group. The question about menstrual bleeding in mothers did not differ significantly. Sensitivity of the questionnaire for a hemostatic disorder was 0.60, while specifity was 0.76. The negative predictive value was 0.82, but the positive predictive value was only 0.52. Conclusions: Our small study shows, that a questionnaire yields good results to exclude a haemostatic disorder, but is not a sensitive tool to identify such a disorder.

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