The Role of Non-Bank Financials in the Formation of Long-Term Resources for Economic Growth in Russia

The development of the activities of non-bank financial institutions that accumulate the resources of the national savings system on a long-term basis is seen as a factor in increasing investment in the Russian economy and its growth rates. When carrying out the study, we used general scientific methods, methods of structural, weigh, and dynamic analysis, and comparisons of performance indicators of non-bank financial institutions. Problems in the activities of organizations in the non-banking sector of the Russian financial market are predetermined by the parameters and trends in the development of the socio-economic situation in Russia, including insufficient efficiency of regulatory practices. The positive dynamics of the development of non-bank financial intermediaries is qualified as unstable; it is not supported by the solution of the structural and institutional problems of the Russian economy. In view of this, an increase in their role in the redistribution process is associated both with decisions of a more general order and with the improvement of the regulatory and supervisory practices implemented by the Bank of Russia. The solution to the identified problems in the development of the non-banking segment of the financial market should be aimed at turning it into an effective mechanism for capital formation to ensure economic growth.

NATURAL PRODUCTS WITH ANTI-HERPES ACTIVITIES: IN VIVO STUDIES

Herpes are a group of similar viruses that are responsible for a number of infecting diseases, the most important of which are herpes simplex, herpes zoster and pseudopox. Resistance to traditional antiviral medications is becoming increasingly common, making treatment of such infections even more difficult. For example, the usage of nucleoside analogues like acyclovir to target the DNA-polymerase of the virus on a regular and long-term basis promotes the generation of resistant viruses. As a result, a different treatment is required. Natural products, such as herbal remedies, have been shown to have in vitro and in vivo activity against herpes viruses, and have shown to be a valuable source for new antivirals development and separation. The goal of this review is to highlight the most promising extracts and pure chemicals obtained from plants and marine species that have in vivo anti-herpes simplex virus (HSV-1 and HSV-2) action. Natural products as new anti-HSV medications offer a number of benefits, including fewer side effects, minimal toxicity, and lowered resistance, and a variety ways of deed.

DECISION-MAKING FACTORS IN CONSUMER BEHAVIOUR ON THE MARKET WITH DECORATIVE COSMETICS

The article explores major decision-making factors in consumer behaviour when purchasing decorative cosmetics. The employed methods involve brainstorming and structured interviews. The most powerful internal stimuli are body care and looking good. On the other hand, a desire to try a new cosmetic product plays a rather subordinate role. The main external purchasing factors involve a recommendation from a friend or relative. On the contrary, aspects such as vegan composition of the product or its packaging do not attract much attention. However, research conclusions cannot apply on the long-term basis given to the rapid development of new technologies and marketing strategies in this branch. It is therefore imperative to monitor the current market trends.

The role of pharmacogenetics in Efficacy and safety of protease inhibitor based therapy in human immunodeficiency virus type (HIV) infection.

Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with human immunodeficiency virus (HIV). HIV can now be classified as a chronic disease; until a cure is found, patients are likely to require life-long therapy. However, despite these undoubted advances, there are many issues that need to be resolved, including the problems associated with long-term efficacy and toxicity. Moreover, pharmacotherapy of patients infected with HIV is challenging because a great number of comorbidities increase polypharmacy and the risk for drug-drug interactions. There is considerable interindividual variability in patient outcomes in terms of drug disposition, drug efficacy and adverse events. The basis of these differences is multifactorial, but host genetics are believed to play a significant part. HIV-infected population consists of ethnically diverse individuals on complex and potentially toxic antiretroviral regimens on a long-term basis. These individuals would benefit greatly from predictive tests that identify the most durable regimens. Pharmacogenetics holds that promise. Thus, detailed understanding of the metabolism and transport of antiretrovirals and the influence of genetics on these pathways is important. To this end, this review provides an up-to-date overview of the metabolism of antiHIV therapeutics of the protease inhibitors Lopinavir and Ritonavir and the impact of genetic variation in drug metabolism and transport on the treatment of HIV.

Development and Implementation of Two Compression Set Tools in a Wellbore Clean Out String

Running two compression set tools in a single wellbore clean out string, typically a bypass tool and negative test packer, has been a significant industry challenge to operate reliably. The need for running these types of tools is generally driven by the need to perform a negative test on a liner top and achieve high flow rates necessary to hydraulically remove debris from the well. Combining these operations into a single run is an increasingly common method to reduce rig time and cost for the operator. Tools to perform this type of operation are generally available from many service providers, however difficulties and challenges arise when trying to manipulate two different tools in the same string that function by the same compression set method. These operations do have a history that is partially successful, however on a long term basis reliability is generally considered poor by most operators, as a failure to manipulate the tools correctly can result in a failed run and a trip out of the hole. This paper discusses the development and successful field deployment of a system of two compression set tools to address this specific challenge while improving reliability over existing solutions.

Perception of Youth Towards Live-In Relationships in India

“A live-in relationship is an arrangement where two unmarried people live together on a long-term basis in an emotionally or sexually intimate relationship” (Gopal, n.d.). Live-in relationships have seen a remarkable rise in the Indian society in the past decade. This rise can be attributed to the changing perception of youth towards live-in relationships, the need to test compatibility before marriage or to establish financial security before marriage. This paper aims to study the current attitude of Indian youth towards heterosexual cohabitation, popularly known as live-in relationships. This paper has tried to understand whether gender-based differences play an important role in the formation of attitudes towards live-in relationships, whether live-in relationships have become a presumption for marriage and if it has taken precedence over the institution of marriage. I constructed a questionnaire to assess the current attitude of youth towards live-in relationships and used the survey method to collect data. According to the results, it can be said that gender-based differences play an important role in the formation of attitudes towards live-in relationships. Although live-in relationships help in assessing compatibility before marriage, it has not become a presumption for marriage, so it would be incorrect to say that live-in relationships have become a testing ground for marriage. The results also indicate that live-in relationships have not taken precedence over marriage.

Indication and uses of temporary anchorage device in orthodontic

Treating various types of malocclusion is dependant on providing a secure anchorage. In this context, it has been shown that teeth, intramaxillary, and/or extraoral appliances are required to achieve favorable outcomes regarding anchorage treatment. A Temporary anchorage device (TAD) has been introduced in the literature in this context. It has been described as a temporary device that can be used after completing treatment. The aim of the study was to review the indications and uses of TADs in orthodontic treatment. The current evidence shows that introducing TADs in the field of orthodontic treatment has been associated with favorable outcomes that encountered the previous multiple challenges reported with the conventional anchorage approaches. Contemporary orthodontic settings reported various uses for TADs, including corrections in transverse, vertical, and anteroposterior dimensions. Combined use of TADs and conventional approaches were also evaluated with favorable outcomes. These findings indicate the validity of TADs in orthodontic treatment and call for its future implications and clinical applications. However, it should be noted that post-treatment evaluation on a long-term basis was not adequately reported in the current literature, indicating the need for future investigations for further validation.

Environmental effects on the mechanical properties of E-glass and S-glass fiber epoxy composite ring specimens used in aircraft fuel pipes

An experimental investigation was performed in predicting the consequences of the exposure to seawater and moisture absorption on the mechanical properties of two different GFRE pipe rings made of E-glass and S-glass fiber and utilized in aircraft fuel pipe line system. Filament winded tubular composite pipe rings were immersed in seawater for two, four and six months, respectively and their moisture absorption was noted. The outcomes exhibit a remarkable decrease in fatigue life for saturated GFRE sample rings. In contrast, a water absorption up to 40% of the maximum content exhibited no impact. The tests revealed debonding and cracks in the fiber and matrix interphase in the case of samples immersed in seawater on a long-term basis, although the applied mechanical load was zero.

QOLP-32. EFFECT OF CANNABIS USE ON QUALITY OF LIFE AMONG GLIOMA PATIENTS: A LONGITUDINAL PERSPECTIVE

BACKGROUND Gliomas are devastating primary tumors of the central nervous system that often present with difficult to manage symptoms in addition to the antineoplastic tumor itself. Due to recent increase in popularity and societal acceptance of cannabis products, their use by glioma patients has increased. METHODS We conducted a single center, prospective study: patients with glioma answered a locally validated survey to inquire about their cannabis use at baseline and every three months. Quality of Life was measured using the EORTC QLQ-C30, its complementary module BN-20 and the EQ-5D-5L instrument. Eligible participants were classified as cannabis users or non-users. We performed linear regression clustered by subjects to see differences by user group and trends overtime. RESULTS To date, 89 patients agreed to participate, enrolled, and answered the baseline questionnaires, and 64 have answered the 3 month follow up survey. The mean age was 49.7(SD 13.74), 55 were male, 55 were cannabis users at baseline (61.8%) and 34 at 3 months (53.13%). Patients who were cannabis users scored 11.73 lower points at baseline when compared to non-users (79.65 [SD 18.93] vs 67.92 [SD 19.22]) in the QLQ-C30 instrument. Similarly, cannabis users recorded 9.624 lower points at 3 months compared to non-users (70.1 [SD 21.33] vs 79.72 [SD13.95]). The difference-in-difference estimator was 2.108 (p< 0.7). CONCLUSION Although we observed cannabis users scoring lower QoL measurements (p< 0.05) at baseline and 3 months, we observed a slight improvement in QoL of cannabis users while observing no change or decline (in some measures) among non-users. Our findings provide insight to the impact that cannabis has in QoL over time. While not conclusive, these preliminary results need to be studied on a longer-term basis with a larger sample size in order to detect trends on quality of life among patients with different tumor types.

UNDERGRADUATE IMPRESSION REGARDING AETCOM AS LEARNING TOOL

Introduction And Objective: Knowledge of proper Attitude, Ethics and Communication Skills with the patients plays a vital role in success of medical professionals. So, AETCOM module has been formulated to train the medical students from first MBBS itself as a part of their foundation course. We wanted to assess the perception of Attitude, Ethics and Communication Skills (AETCOM) Module by first MBBS students as a learning tool in their foundation course. Methods: 1. This is a cross sectional observational study conducted over a period of one month involving first year MBBS students who joined in the year 2019-20 in Private medical college at Chhattisgarh. 2. 105 students were included in this study. 3. The teaching schedule of AETCOM Module had four sessions three hours each. 4. At the end of the AETCOM module feedback on their perception was collected. Results: A majority of the students (77.14%) agreed that the AETCOM Module will definitely improve their communication skills with the patients. They also felt that this type of teaching should be included in their regular curriculum and this should be an ongoing process throughout their semester. Students views on AETCOM were- asset for gaining confidence of the patients (87.62%), useful for themselves and for future practice, excellent method for improvement of diagnosis (81.90%). Conclusion: The AETCOM Module will definitely help students on long-term basis. It will help them gain confidence and develop good communication skills for a better doctor patient relationship.