scholarly journals RNA Virus Evolution via a Quasispecies-Based Model Reveals a Drug Target with a High Barrier to Resistance

Viruses ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 347 ◽  
Author(s):  
Richard Bingham ◽  
Eric Dykeman ◽  
Reidun Twarock
Keyword(s):  
Drug Target ◽  
Rna Virus ◽  
Virus Evolution

scholarly journals Diminishing returns of inoculum size on the rate of a plant RNA virus evolution

2017 ◽  
Vol 120 (3) ◽  
pp. 38001
Author(s):  
Rebeca Navarro ◽  
Silvia Ambrós ◽  
Fernando Martínez ◽  
Santiago F. Elena
Keyword(s):  
Rna Virus ◽  
Virus Evolution ◽  
Inoculum Size ◽  
Diminishing Returns

scholarly journals A continuous phenotype space model of RNA virus evolution within a host

2014 ◽  
Vol 11 (4) ◽  
pp. 919-927 ◽  
Author(s):  
Andrei Korobeinikov ◽  
◽  
Conor Dempsey ◽  
Keyword(s):  
Rna Virus ◽  
Virus Evolution ◽  
Space Model ◽  
Phenotype Space ◽  
Continuous Phenotype

scholarly journals Viromes in Marine Ecosystems Reveal Remarkable Invertebrate RNA Virus Diversity

2021 ◽  
Author(s):  
Yu-Yi Zhang ◽  
Yicong Chen ◽  
Xiaoman Wei ◽  
Jie Cui
Keyword(s):  
Rna Viruses ◽  
Rna Virus ◽  
Marine Invertebrate ◽  
Ecological Factors ◽  
Virus Evolution ◽  
Marine Ecosystems ◽  
Invertebrate Species ◽  
Virus Diversity ◽  
First Time ◽  
Special Notice

AbstractOcean viromes remain poorly understood and little is known about the ecological factors driving aquatic RNA virus evolution. In this study, we used a meta-transcriptomic approach to characterize the viromes of 58 marine invertebrate species across three seas. This revealed the presence of 315 newly identified RNA viruses in nine viral families or orders (Durnavirales, Totiviridae, Bunyavirales, Hantaviridae, Picornavirales, Flaviviridae, Hepelivirales, Solemoviridae and Tombusviridae), with most of them are sufficiently divergent to the documented viruses. With special notice that we first time revealed an ocean virus rooting to mammalian hantaviruses. We also found evidence for possible host sharing and switch events during virus evolution. In sum, we demonstrated the hidden diversity of marine invertebrate RNA viruses.

scholarly journals High-Order Epistasis and Functional Coupling of Infection Steps Drive Virus Evolution toward Independence from a Host Pathway

2021 ◽  
Author(s):  
Minetaro Arita
Keyword(s):  
Viral Replication ◽  
Rna Virus ◽  
Virus Evolution ◽  
High Order ◽  
Host Factors ◽  
Functional Coupling

Each virus has a different strategy for its replication, which requires different host factors. Enterovirus, a model RNA virus, requires host factors PI4KB and OSBP, which form an obligatory functional axis to support viral replication.

scholarly journals Expanding networks of RNA virus evolution

BMC Biology ◽  
2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Eugene V Koonin ◽  
Valerian V Dolja
Keyword(s):  
Rna Virus ◽  
Virus Evolution

RNA Virus Evolution via a Fitness-Space Model

1996 ◽  
Vol 76 (23) ◽  
pp. 4440-4443 ◽  
Author(s):  
Lev S. Tsimring ◽  
Herbert Levine ◽  
David A. Kessler
Keyword(s):  
Rna Virus ◽  
Virus Evolution ◽  
Space Model

Two distinct sites are essential for virulent infection and support of variant satellite RNA replication in spontaneous beet black scorch virus variants

2012 ◽  
Vol 93 (12) ◽  
pp. 2718-2728 ◽  
Author(s):  
Jin Xu ◽  
Xianbing Wang ◽  
Lindan Shi ◽  
Yuan Zhou ◽  
Dawei Li ◽  
...  
Keyword(s):  
Rna Virus ◽  
Point Mutations ◽  
Virus Evolution ◽  
Biological Properties ◽  
Site Directed Mutagenesis ◽  
Cdna Clones ◽  
Sequence Alignments ◽  
Chenopodium Amaranticolor ◽  
Beet Black Scorch Virus

Spontaneous point mutations of virus genomes are important in RNA virus evolution and often result in modifications of their biological properties. Spontaneous variants of beet black scorch virus (BBSV) and its satellite (sat) RNA were generated from cDNA clones by serial propagation in Chenopodium amaranticolor and Nicotiana benthamiana. Inoculation with recombinant RNAs synthesized in vitro revealed BBSV variants with divergent infectious phenotypes that affected either symptom expression or replication of satRNA variants. Sequence alignments showed a correlation between the phenotypes and distinct BBSV genomic loci in the 3′UTR or in the domain encoding the viral replicase. Comparative analysis between a virulent variant, BBSV-m294, and the wild-type (wt) BBSV by site-directed mutagenesis indicated that a single-nucleotide substitution of a uridine to a guanine at nt 3477 in the 3′UTR was responsible for significant increases in viral pathogenicity. Gain-of-function analyses demonstrated that the ability of the BBSV variants to support replication of variant satRNAs was mainly determined by aa 516 in the P82 replicase. In this case, an arginine substitution for a glutamine residue was essential for high levels of replication, and alterations of other residues surrounding position 516 in the wtBBSV isolate led to only minor phenotypic effects. These results provide evidence that divergence of virus functions affecting pathogenicity and supporting parasitic replication can be determined by a single genetic site, either a nucleotide or an amino acid. The results suggest that complex interactions occur between virus and associated satRNAs during virus evolution.

Future issues in RNA virus evolution

2006 ◽  
Vol 1 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Edward C Holmes
Keyword(s):  
Rna Virus ◽  
Virus Evolution
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