scholarly journals Natural Self-Ligand Gamma Delta T Cell Receptors (γδTCRs) Insight: The Potential of Induced IgG

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 436 ◽  
Author(s):  
Thamires Rodrigues de Sousa ◽  
Jefferson Russo Victor
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Cell Receptor ◽  
Actual State ◽  
Γδ T Cell ◽  
Gamma Delta ◽  
Cell Receptors ◽  
Theoretical Contribution ◽  
Almost All ◽  
Gamma Delta T Cell

A γδ T cell acquires functional properties in response to the gamma delta T cell receptor γδTCR signal strength during its development in the thymus. The elucidation of the potential ligands of γδ T cell receptors are of extreme importance; however, they are still not understood. Here we revise the actual state of the art of candidates to exert the function of γδTCR ligands, and propose a theoretical contribution about new potential ligands of γδTCRs, based on biological and hypothetical pieces of evidence in the literature. In conclusion, we hypothetically suggest a possible role of induced antibodies according to the individual’s immune status, mainly of the IgG subclass, acting as γδTCR ligands. Considering that IgG production is involved in some essential immunotherapy protocols, and almost all vaccination protocols, our discussion opens a new and broad field to further exploration.

scholarly journals Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development.

1989 ◽  
Vol 86 (2) ◽  
pp. 631-635 ◽  
Author(s):  
K. Ito ◽  
M. Bonneville ◽  
Y. Takagaki ◽  
N. Nakanishi ◽  
O. Kanagawa ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Gamma Delta ◽  
Stages Of Development ◽  
Cell Receptors ◽  
Gamma Delta T Cell

scholarly journals Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23

2010 ◽  
Vol 34 (4) ◽  
pp. 478-484 ◽  
Author(s):  
Li Zhang ◽  
Niyun Jin ◽  
Maki Nakayama ◽  
Rebecca L. O'Brien ◽  
George S. Eisenbarth ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Gamma Delta ◽  
Cell Receptors ◽  
Gamma Delta T Cell

Gamma/delta T-cell receptors

The Lancet ◽  
1991 ◽  
Vol 337 (8741) ◽  
pp. 613 ◽  
Author(s):  
W LONDON
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Gamma Delta ◽  
Cell Receptors ◽  
Gamma Delta T Cell

Human thymocytes expressing gamma/delta T-cell receptors

1989 ◽  
Vol 44 (S1) ◽  
pp. 39-42 ◽  
Author(s):  
M. C. Mingari ◽  
P. Varese ◽  
C. Bottino ◽  
G. Tambussi ◽  
L. Moretta
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Gamma Delta ◽  
Cell Receptors ◽  
Gamma Delta T Cell

Gamma/delta T-cell receptors

The Lancet ◽  
1991 ◽  
Vol 337 (8744) ◽  
pp. 796
Author(s):  
Ilan Bank
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Gamma Delta ◽  
Cell Receptors ◽  
Gamma Delta T Cell

Lymphocytes Bearing the gamma/delta T-Cell Receptors in Down's Syndrome

1992 ◽  
Vol 35 (3) ◽  
pp. 275-278 ◽  
Author(s):  
A. BERTOTTO ◽  
F. SCALISE ◽  
R. GERLI ◽  
G. CASTELLUCCI ◽  
G. M. FABIETTI ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Gamma Delta ◽  
Cell Receptors ◽  
Gamma Delta T Cell

scholarly journals Alternative splicing restricts translation of rearrangements at the T- cell receptor delta/alpha locus

Blood ◽  
1995 ◽  
Vol 85 (7) ◽  
pp. 1888-1896 ◽  
Author(s):  
TE Hansen-Hagge ◽  
C Mahotka ◽  
RE Panzer-Grumayer ◽  
HJ Reuter ◽  
K Schwarz ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
T Cell ◽  
T Cell Receptors ◽  
Cell Receptor ◽  
Variable Domain ◽  
Gamma Delta ◽  
Alpha Cluster ◽  
Gamma Delta T Cell ◽  
Reh Cells ◽  
Rearrangement Processes

Lymphocytes expressing alpha beta or gamma delta T-cell receptors (TCR) represent distinct T-cell populations. Because TCR delta genes lie within the TCR alpha locus, the rearrangement processes, transcription, and translation of TCR delta or TCR alpha variable domain exons require tight regulation. Human precursor B-cell leukemias (eg, the REH cell line) constitute an interesting model to study TCR delta/alpha recombination because they rearrange TCR delta/alpha loci along a hierarchically ordered pathway in which V delta 2D delta 3 segments are joined to the J alpha cluster. We now show for REH cells that chimeric TCR delta/alpha variable domain exons are posttranscriptionally modified by alternative splicing resulting in truncated V delta 2C alpha transcripts. This process also takes place during thymic differentiation. CD7+/CD3- T-cell precursors exhibit V delta 2D delta 3 rearrangements. Further differentiation into CD7+/CD3+ thymocytes is associated with the expression of a truncated V delta 2C alpha RNA species. In contrast, chimeric TCR delta/alpha rearrangements containing a V delta 1 segment (but no D delta sequences) are predominantly expressed as full-length V delta 1J alpha C alpha transcripts. These data suggest that alternative splicing constitutes a mechanism that restricts the production of distinct chimeric TCR alpha chains.

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