Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy

Vaccinations are a key prevention measure in fighting the COVID-19 pandemic. The BNT162b2 mRNA vaccine (BioNTech/Pfizer), the first to receive authorization, was widely used in the mass vaccination campaign in Italy. Healthcare workers were identified as a priority group for vaccination, but few studies have assessed its reactogenicity among the young working age population. An online survey was conducted to investigate the adverse reactions occurring in the 7 days following the first and second vaccination doses amongst resident doctors of the University of Genoa, employed at the IRCCS Ospedale Policlinico San Martino of Genoa, between 11 January and 16 March 2021. A total of 512 resident physicians were invited to participate in the study (female = 53.2%; mean age = 28.9 years), of whom 296 (female = 53.4%, mean age = 28.9 years) and 275 (female = 55.3%, mean age = 29.1 years) completed the survey after their first and second vaccination doses, respectively. In the 7 days following the first dose, most common adverse reactions were local pain (96.3%), fatigue (42.6%), headache (33.8%), arthromyalgia (28.0%), and 5.1% reported fever, while following the second dose, participants reported local pain (93.5%), fatigue (74.9%), headache (57.5%), arthromyalgia (58.2%), and fever (30.9%), with a higher prevalence among females. Systemic (but not local) reactions increased following the second vaccination, reaching severe intensity in 9.8% of participants and causing three or more events of moderate intensity in 23.7% of participants. Adverse reactions preventing regular daily activities could cause absenteeism among workers. These results can be useful to inform populations of young individuals, set expectations, and improve adherence to vaccination campaigns.

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Parents’ and Adolescents’ Willingness to be Vaccinated Against Serogroup B Meningococcal Disease during a Mass Vaccination in Saguenay–Lac-St-Jean (Quebec)

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2015/732464 ◽

2015 ◽

Vol 26 (3) ◽

pp. 163-167 ◽

Cited By ~ 11

Author(s):

Eve Dubé ◽

Dominique Gagnon ◽

Denis Hamel ◽

Sylvie Belley ◽

Hélène Gagné ◽

...

Keyword(s):

Meningococcal Disease ◽

Endemic Area ◽

Telephone Survey ◽

Vaccination Campaign ◽

Negative Attitude ◽

Mass Vaccination ◽

Mass Vaccination Campaign ◽

4Cmenb Vaccine ◽

Self Protection ◽

To Receive

A mass vaccination campaign with the 4CMenB vaccine (Bexsero®; Novartis Pharmaceutical Canada Inc) was launched in a serogroup B endemic area in Quebec. A telephone survey was conducted to assess parental and adolescent opinions about the acceptability of the vaccine. Intent to receive the vaccine or vaccine receipt was reported by the majority of parents (93%) and adolescents (75%). Meningitis was perceived as being a dangerous disease by the majority of parents and adolescents. The majority of respondents also considered the 4CMenB vaccine to be safe and effective. The main reason for positive vaccination intention or behaviour was self-protection, while a negative attitude toward vaccination in general was the main reason mentioned by parents who did not intend to have their child vaccinated. Adolescents mainly reported lack of interest, time or information, and low perceived susceptibility and disease severity as the main reasons for not intending to be vaccinated or not being vaccinated.

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Impact of a mass vaccination campaign against a meningitis epidemic in a refugee camp

Tropical Medicine & International Health ◽

10.1046/j.1365-3156.1996.d01-49.x ◽

1996 ◽

Vol 1 (3) ◽

pp. 385-392 ◽

Cited By ~ 20

Author(s):

Edwige Haelterman ◽

Marleen Boelaert ◽

Carl Suetens ◽

Lucie Blok ◽

Myriam Henkens ◽

...

Keyword(s):

Vaccination Campaign ◽

Refugee Camp ◽

Mass Vaccination ◽

Mass Vaccination Campaign

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Measles Outbreak Associated With Low Vaccine Effectiveness Among Adults in Pohnpei State, Federated States of Micronesia, 2014

Open Forum Infectious Diseases ◽

10.1093/ofid/ofw064 ◽

2016 ◽

Vol 3 (2) ◽

Cited By ~ 15

Author(s):

Craig M. Hales ◽

Eliaser Johnson ◽

Louisa Helgenberger ◽

Mark J. Papania ◽

Maribeth Larzelere ◽

...

Keyword(s):

Confidence Interval ◽

Vaccination Campaign ◽

Vaccine Effectiveness ◽

Mass Vaccination ◽

Cold Chain ◽

Primary Case ◽

Federated States Of Micronesia ◽

Measles Outbreak ◽

Mass Vaccination Campaign ◽

Vaccination Campaigns

Abstract Background. A measles outbreak in Pohnpei State, Federated States of Micronesia in 2014 affected many persons who had received ≥1 dose of measles-containing vaccine (MCV). A mass vaccination campaign targeted persons aged 6 months to 49 years, regardless of prior vaccination. Methods. We evaluated vaccine effectiveness (VE) of MCV by comparing secondary attack rates among vaccinated and unvaccinated contacts after household exposure to measles. Results. Among 318 contacts, VE for precampaign MCV was 23.1% (95% confidence interval [CI], −425 to 87.3) for 1 dose, 63.4% (95% CI, −103 to 90.6) for 2 doses, and 95.9% (95% CI, 45.0 to 100) for 3 doses. Vaccine effectiveness was 78.7% (95% CI, 10.1 to 97.7) for campaign doses received ≥5 days before rash onset in the primary case and 50.4% (95% CI, −52.1 to 87.9) for doses received 4 days before to 3 days after rash onset in the primary case. Vaccine effectiveness for most recent doses received before 2010 ranged from 51% to 57%, but it increased to 84% for second doses received in 2010 or later. Conclusions. Low VE was a major source of measles susceptibility in this outbreak; potential reasons include historical cold chain inadequacies or waning of immunity. Vaccine effectiveness of campaign doses supports rapid implementation of vaccination campaigns in outbreak settings.

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Impacts of a mass vaccination campaign against pandemic H1N1 2009 influenza in Taiwan: a time-series regression analysis

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2014.02.016 ◽

2014 ◽

Vol 23 ◽

pp. 82-89 ◽

Cited By ~ 9

Author(s):

Un-In Wu ◽

Jann-Tay Wang ◽

Shan-Chwen Chang ◽

Yu-Chung Chuang ◽

Wei-Ru Lin ◽

...

Keyword(s):

Time Series ◽

Regression Analysis ◽

Vaccination Campaign ◽

Mass Vaccination ◽

Pandemic H1n1 ◽

Time Series Regression ◽

Mass Vaccination Campaign ◽

Pandemic H1n1 2009

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The effect of mass influenza immunization in children on the morbidity of the unvaccinated elderly

Epidemiology and Infection ◽

10.1017/s0950268805005650 ◽

2005 ◽

Vol 134 (1) ◽

pp. 71-78 ◽

Cited By ~ 70

Author(s):

Y. Z. GHENDON ◽

A. N. KAIRA ◽

G. A. ELSHINA

Keyword(s):

Vaccination Campaign ◽

Clinical Effectiveness ◽

Mass Vaccination ◽

Elderly Persons ◽

Influenza Epidemic ◽

Home Setting ◽

Institutionalized Elderly ◽

Influenza Immunization ◽

Mass Vaccination Campaign ◽

Significant Mass

SUMMARYThe objectives of these studies were to analyse the effect of mass influenza immunization in children on the morbidity of unvaccinated non-institutionalized elderly during an influenza epidemic. A mass vaccination campaign with vaccine was conducted in children aged 3–6 years attending kindergartens (57·4% of 6374) and aged 7–17 years attending schools (72% of 34 237) in two communities of the Moscow region. The clinical effectiveness of vaccination was 60·9% for kindergartens and 68·8% for schools. There were 3·4 times fewer episodes of influenza-like illnesses and 1·7–2·6 fewer episodes in all seven diseases which are possible complications of influenza out of the 10 evaluated diseases in 158 451 unvaccinated non-institutionalized elderly people during the influenza epidemic compared with the control communities. The differences were found to be statistically significant. Mass vaccination of children attending child institutions brought about a significant reduction of both influenza-like illnesses in children and influenza-associated illnesses in unvaccinated non-institutionalized elderly persons living in the home setting.

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