The use of the negative pressure wound therapy in management of the perineal wounds after abdominal-perineal extirpation (literature review)

2021 ◽  
pp. 36-48
Author(s):  
Alexey Musin ◽  
Leonid Kornev ◽  
Olga Povarichina ◽  
Evgeny Naumov
Keyword(s):  
Negative Pressure ◽  
Randomized Trials ◽  
Negative Pressure Wound Therapy ◽  
Objective Assessment ◽  
Perineal Wound ◽  
Wound Therapy ◽  
Wound Area ◽  
Scientific Papers ◽  
Perineal Wounds ◽  
The Moment

The review presents data from the analysis of the literature on various options of using negative pressure wound therapy after abdominal-perineal extirpation of the rectum. We have selected 10 scientific papers for analysis, and no randomized trials have been found in the literature. The use of local negative pressure led to an acceleration of tissue repair and a decrease in complications in the perineal wound area. However, at the moment, the data presented in the literature are insufficient for an objective assessment of the effectiveness of the technique. It is necessary to conduct randomized trials to objectively evaluate the methodology.

scholarly journals The role of perineal application of prophylactic negative-pressure wound therapy for prevention of wound-related complications after abdomino-perineal resection: a systematic review

2020 ◽  
Vol 36 (1) ◽  
pp. 19-26
Author(s):  
Jeremy Meyer ◽  
Elin Roos ◽  
Ziad Abbassi ◽  
Christian Toso ◽  
Frédéric Ris ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Lower Incidence ◽  
Negative Pressure Wound Therapy ◽  
Web Of Science ◽  
Wound Dehiscence ◽  
Site Infection ◽  
Wound Therapy ◽  
Perineal Resection ◽  
Perineal Wounds

Abstract Background Closed perineal wounds often fail to heal by primary intention after abdomino-perineal resection (APR) and are often complicated by surgical site infection (SSI) and/or wound dehiscence. Recent evidence showed encouraging results of prophylactic negative-pressure wound therapy (pNPWT) for prevention of wound-related complications in surgery. Our objective was to gather and discuss the early existing literature regarding the use of pNPWT to prevent wound-related complications on perineal wounds after APR. Methods Medline, Embase, and Web of Science were searched for original publications and congress abstracts reporting the use of pNPWT after APR on closed perineal wounds. Results Seven publications were included for analysis. Two publications reported significantly lower incidence of SSI in pNPWT patients than in controls with a risk reduction of about 25–30%. Two other publications described similar incidences of SSI between the two groups of patients but described SSI in pNPWT patients to be less severe. One study reported significantly lower incidence of wound dehiscence in pNPWT patients than in controls. Conclusion The largest non-randomized studies investigating the effect of pNPWT on the prevention of wound-related complications after APR showed encouraging results in terms of reduction of SSI and wound dehiscence that deserve further investigation and confirmation.

Impact of incisional negative pressure wound therapy on perineal wound healing after abdominoperineal rectum extirpation

2016 ◽  
Vol 32 (2) ◽  
pp. 291-293 ◽  
Author(s):  
Armin Wiegering ◽  
Ulrich A. Dietz ◽  
Caroline Corteville ◽  
Lars Plaßmeier ◽  
Christian Jurowich ◽  
...  
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Perineal Wound ◽  
Wound Therapy ◽  
Perineal Wound Healing ◽  
Rectum Extirpation

scholarly journals The Effect of Negative Pressure Wound Therapy for Perineal Wound after Rectal Amputation

2016 ◽  
Vol 69 (7) ◽  
pp. 367-373
Author(s):  
Tomoaki Kaneko ◽  
Kimihiko Funahashi ◽  
Mayu Goto ◽  
Kimihiko Yoshida ◽  
Jyuniti Koike ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Perineal Wound ◽  
Wound Therapy

Incisional negative pressure wound therapy for perineal wound in Crohn's disease

2021 ◽  
Author(s):  
Mikihiro Inoue ◽  
Keiichi Uchida ◽  
Kohei Matsushita ◽  
Yuhki Koike ◽  
Yuji Toiyama
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Perineal Wound ◽  
Wound Therapy

scholarly journals Technical Support of Wound Healing Processes: Project Status

2019 ◽  
Vol 5 (1) ◽  
pp. 521-523
Author(s):  
Jacquelyn Dawn Parente ◽  
Knut Möller ◽  
Sabine Hensler ◽  
Claudia Kühlbach ◽  
Margareta M. Mueller ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mathematical Models ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Technical Support ◽  
Wound Therapy ◽  
Wound Area ◽  
Modal Treatment ◽  
Healing Processes

AbstractThe optimized wound healing (OWID) project provides technical support of wound healing processes. Advanced biophysical treatment therapies using light (photobiomodulation), negative pressure wound therapy (NPWT), and electrical stimulation show biological effects. Specifically, a biphasic dose-response curve is observed where lower doses activate cells, while above a threshold, higher doses are inhibitory. However, no standard protocols and no multi-modal treatment studies determine specific therapy needs. The OWID project aims to develop a multi-modal treatment device and modelbased therapy for individualized wound healing. This work presents the OWID project status. Currently, a photobiomodulation prototype delivers red, green, and blue light ‘medicine’ at prescribed therapeutic ‘doses’. The calculation of incident light necessarily considers transmission properties of the intervening cell culture plate. Negative pressure wound therapy (NPWT) and electrical impedance tomography (EIT) hardware are being adapted for use in vitro. Development of mathematical models of wound healing and therapy control are supported by treatment experiment outcome measures conducted in a wounded 3D tissue model. Parameter sensitivity analysis conducted on an existing mathematical model of reepithelialization results in changing parameter values influencing cellular movement rates. Thus, the model is robust to fit model parameters to observed reepithelialization rates under treatment conditions impacting cellular activation, inhibition, and untreated controls. Developed image analysis techniques have not captured changes in wound area after photobiomodulation treatment experiments. Alternatively, EIT will be tested for wound area analysis. Additionally, live dyes will be introduced to non-invasively visualize the reepithelialization front on a smaller, cellular scale. Finally, an overall therapeutic feedback control model uses model reference adaptive control to incorporate the intrinsic biological reepithelialization mechanism, treatment loops, and treatment controller modulation at a wound state. Currently, the OWID project conducts photobiomodulation treatment experiments in vitro and has developed mathematical models. Future work includes the incorporation of multi-modal wound healing treatment experiments.

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