Incisional Negative-Pressure Wound Therapy for Perineal Wounds After Abdominoperineal Resection for Rectal Cancer, a Pilot Study

Abstract Background Closed perineal wounds often fail to heal by primary intention after abdomino-perineal resection (APR) and are often complicated by surgical site infection (SSI) and/or wound dehiscence. Recent evidence showed encouraging results of prophylactic negative-pressure wound therapy (pNPWT) for prevention of wound-related complications in surgery. Our objective was to gather and discuss the early existing literature regarding the use of pNPWT to prevent wound-related complications on perineal wounds after APR. Methods Medline, Embase, and Web of Science were searched for original publications and congress abstracts reporting the use of pNPWT after APR on closed perineal wounds. Results Seven publications were included for analysis. Two publications reported significantly lower incidence of SSI in pNPWT patients than in controls with a risk reduction of about 25–30%. Two other publications described similar incidences of SSI between the two groups of patients but described SSI in pNPWT patients to be less severe. One study reported significantly lower incidence of wound dehiscence in pNPWT patients than in controls. Conclusion The largest non-randomized studies investigating the effect of pNPWT on the prevention of wound-related complications after APR showed encouraging results in terms of reduction of SSI and wound dehiscence that deserve further investigation and confirmation.

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Negative-Pressure Wound Therapy as Prophylaxis for Surgical Site Infection in Perineal Wounds

Pressure Injury, Diabetes and Negative Pressure Wound Therapy - Recent Clinical Techniques, Results, and Research in Wounds ◽

10.1007/15695_2017_52 ◽

2017 ◽

pp. 241-244

Author(s):

Patrick B. Murphy ◽

Michael Ott

Keyword(s):

Surgical Site Infection ◽

Negative Pressure ◽

Negative Pressure Wound Therapy ◽

Site Infection ◽

Wound Therapy ◽

Perineal Wounds

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Analysis of Rinsing Fluid during Negative Pressure Wound Therapy with Instillation: A Potential Monitoring Tool in Acute and Chronic Wound Treatment. A Pilot Study

Cells ◽

10.3390/cells10040732 ◽

2021 ◽

Vol 10 (4) ◽

pp. 732

Author(s):

Christian D. Taeger ◽

Stefan Wallner ◽

Teresa Martini ◽

Daniel Schiltz ◽

Andreas Kehrer ◽

...

Keyword(s):

Pilot Study ◽

Negative Pressure ◽

Total Protein ◽

Bacterial Infections ◽

Negative Pressure Wound Therapy ◽

Chronic Wounds ◽

Postoperative Bleeding ◽

Potassium Phosphate ◽

Polymorphonuclear Cells ◽

Wound Therapy

Background: During negative pressure wound therapy (NPWT), open wounds are draped with a nontransparent sponge, making daily wound evaluation impossible. Sometimes, late or undetected bacterial infections and postoperative bleeding result in repetitive surgery, thus prolonging inpatient time. With the introduction of additional fluid instillation (NPWTi), the wound surface is rinsed, and bacteria, proteins and biomarkers are flushed into a collecting canister, which is later discarded. Methods: The aim of this pilot study was to analyze rinsing fluid samples (0.9% sodium chloride) from the NPWTi device in patients with acute and chronic wounds. In 31 consecutive patients a standardized laboratory analysis was performed to evaluate cellular composition and potassium, phosphate, lactate dehydrooxygenase, pH and total protein levels. Results: While there was an increase in the total cellular amount and the number of polymorphonuclear cells, the number of red blood cells (RBC) decreased after surgery. Potassium and pH showed no significant changes in the first three postoperative days, whereas total protein showed an undulant and partially significant course. Conclusion: We were able to quantify cellular metabolites by analyzing the rinsing fluid of NPWTi. We propose the analysis of this material as a novel and potentially promising tool to monitor wound status without removal of the dressing. The establishment of reference values might help to improve the NPWTi therapy.

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NEGATIVE PRESSURE WOUND THERAPY IN THE PREVENTION OF INFECTIOUS WOUND COMPLICATIONS IN PERINEAL WOUND AFTER ABDOMINOPERINEAL RESECTION

Wounds and wound infections The prof B M Kostyuchenok journal ◽

10.17650/2408-9613-2015-2-4-27-31 ◽

2016 ◽

Vol 2 (4) ◽

pp. 27-31

Author(s):

G. V. Rodoman ◽

N. V. Mal’gina ◽

V. N. Razbirin ◽

V. N. Obolenskiy ◽

A. A. Ermolov

Keyword(s):

Abdominoperineal Resection ◽

Negative Pressure ◽

Negative Pressure Wound Therapy ◽

Perineal Wound ◽

Wound Complications ◽

Wound Therapy

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The effect of closed-incision negative pressure wound therapy on clinical and ultrasonographic seroma formation and wound healing following forequarter amputation in large dogs - a randomized pilot trial

Vlaams Diergeneeskundig Tijdschrift ◽

10.21825/vdt.v89i4.16577 ◽

2020 ◽

Vol 89 (4) ◽

pp. 198-207

Author(s):

N. Vallarino ◽

N. Devriendt ◽

A. Koenraadt ◽

M. Or ◽

E. Stock ◽

...

Keyword(s):

Wound Healing ◽

Pilot Study ◽

Negative Pressure ◽

Scoring System ◽

Negative Pressure Wound Therapy ◽

Pilot Trial ◽

Seroma Formation ◽

Control Group ◽

Wound Therapy ◽

Forequarter Amputation

This pilot study aimed at evaluating whether closed-incision negative pressure wound therapy (ciNPWT) has an effect on seroma formation and wound healing following forequarter amputation in dogs above 20 kg. Twelve client-owned dogs weighing more than 20 kg, presented for forequarter amputation, were randomly assigned after surgery into two groups (six ciNPWT and six controls with soft-padded bandage, both bandages applied for three days). A clinical and ultrasonographic control (newly developed scoring system) was performed at bandage removal (three days postoperatively) and ten days, postoperatively. A postoperative seroma was present in 4/6 dogs in the ciNPWT group and in 5/6 dogs in the control group. There were no apparent differences in the ultrasonographic scores or subcutis measurements at three versus ten days, postoperatively. The results of this pilot trial do not support expansion to a larger-scale study evaluating ciNPWT after forequarter amputation in dogs.

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