scholarly journals A rare discovery in the left atrium: A high-grade sarcoma with cerebral metastasis

2021 ◽  
Vol 79 (12) ◽  
pp. 1397-1398
Author(s):  
Daria Kaczmarek ◽  
Oliwia Matuszewska-Brycht ◽  
Jarosław Drożdż ◽  
Mirosław Wilczyński ◽  
Jacek Musiał ◽  
...  
Keyword(s):  
Left Atrium ◽  
Cerebral Metastasis ◽  
High Grade ◽  
High Grade Sarcoma

Acute Aortic Thromboembolism After Right Middle and Lower Bilobectomy for Metastatic High-Grade Sarcoma

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A37
Author(s):  
Adil Malik ◽  
Andrew Serdiuk ◽  
David Thrush ◽  
Evan Glazer ◽  
Puya Alikhani ◽  
...  
Keyword(s):  
High Grade ◽  
High Grade Sarcoma

scholarly journals Neoadjuvant concurrent chemoradiotherapy with and without hyperthermia in retroperitoneal and intra-abdominal sarcomas: Feasibility, efficacy, toxicity and long-term outcome

2021 ◽  
Author(s):  
Alexander Willner ◽  
Katja Fechner ◽  
Abbas Agaimy ◽  
Florian Haller ◽  
Markus Eckstein ◽  
...  
Keyword(s):  
Neoadjuvant Chemoradiotherapy ◽  
Tumor Control ◽  
High Grade ◽  
Regional Hyperthermia ◽  
Abdominal Tumor ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
High Grade Sarcoma

Abstract Background Retroperitoneal (RPS) and intra-abdominal sarcomas (IAS) are associated with poor local and abdominal tumor control. Yet, the benefit of preoperative radio- or chemotherapy alone for these entities currently is unclear. Moreover, as intermediate- and high-grade sarcomas have a tendency for early metastasis, exploration of neoadjuvant strategies is of high importance. This analysis reports the results of our 20-year single-institution experience with preoperative neoadjuvant concurrent chemoradiation.Methods From 2000-2019, 27 patients with intermediate- or high-grade RPS or IAS (12 dedifferentiated liposarcoma, 10 leiomyosarcoma, 5 others) were treated with radiotherapy (median dose: 50.4 Gy; range 45-75 Gy) and two cycles of chemotherapy (doxorubicin 50mg/m² BSA/d3 q28 and ifosfamide 1.5g/m2 BSA/d1-5 q28) in neoadjuvant intention. Chemotherapy consisted of doxorubicin alone in two cases and ifosfamide alone in one case. Fifteen patients (56%) received deep regional hyperthermia additionally.Results The median follow-up time was 53 months (± 56.7 months). 92% of patients received two cycles of chemotherapy as planned and 92% underwent surgery. At 5 and 10 years, abdominal-recurrence-free-survival was 74.6% (± 10.1%) and 66.3% (± 11.9%), distant-metastasis-free-survival was 67.2% (± 9.7%) and 59.7% (± 11.1%), and overall-survival was 60.3% (± 10.5%) and 60.3% (± 10.5%), respectively. CTC grade III and IV toxicities were leukocytopenia (85%), thrombocytopenia (33%) and anemia (11%). There were no treatment-related deaths.Conclusions Neoadjuvant chemoradiotherapy with and without hyperthermia for retroperitoneal and intra-abdominal sarcoma is feasible and provided high local control of intermediate - and high-grade sarcoma.

Emergence of a High-Grade Sarcoma in a Recurrent Meningioma: Malignant Progression or Collision Tumor?

2011 ◽  
Vol 135 (7) ◽  
pp. 935-940
Author(s):  
Buge Oz ◽  
Melike Pekmezci ◽  
Reza Dashti ◽  
Kutlay Karaman ◽  
Cengiz Kuday ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Neurofibromatosis Type ◽  
Collision Tumor ◽  
World Health ◽  
Malignant Neoplasms ◽  
High Grade ◽  
Multiple Meningiomas ◽  
Short Period ◽  
High Grade Sarcoma ◽  
Health Organization

Abstract Anaplastic meningiomas that resemble sarcomas often reveal clues to their meningothelial differentiation or develop in a plausible setting that confirms their meningothelial origin. Malignant mesenchymal neoplasms without obvious evidence of meningothelial differentiation or origin are more likely to be true primary or metastatic sarcomas. Because of their clinical and biological differences, it is important to distinguish anaplastic meningioma from a sarcoma. We present a 67-year-old woman with multiple meningiomas, who developed a high-grade spindle cell tumor 6 months after the resection of a World Health Organization grade I meningioma. It was not clear whether this tumor represented a malignant transformation of meningioma or a primary sarcoma. Malignant transformation of a meningioma is exceptional within this short period and a coexisting sarcoma and meningioma are equally uncommon. Even though these malignant neoplasms are rare in general, they appear to be more prevalent in patients with multiple meningiomas including those with neurofibromatosis type 2.

scholarly journals RASAL2-RET: a novel RET rearrangement in a patient with high-grade sarcoma of the chest

2020 ◽  
Vol 31 (5) ◽  
pp. 659-661
Author(s):  
Y. Zhou ◽  
C. Qi ◽  
M.Z. Xiao ◽  
S.L. Cai ◽  
B.J. Chen
Keyword(s):  
High Grade ◽  
High Grade Sarcoma ◽  
Ret Rearrangement

High-grade Sarcoma Masquerading as Growing Teratoma Syndrome After Resection of Ovarian Immature Teratoma

2012 ◽  
Vol 31 (3) ◽  
pp. 276-279 ◽  
Author(s):  
Elizabeth G. Morency ◽  
Dimitry Lerner ◽  
Roberto Garcia ◽  
Tamara Kalir
Keyword(s):  
Immature Teratoma ◽  
High Grade ◽  
Growing Teratoma Syndrome ◽  
High Grade Sarcoma

scholarly journals Pleomorphic high-grade sarcoma of the heart mimicking cardiac myxoma

2012 ◽  
Vol 2012 (mar08 1) ◽  
pp. bcr1220115277-bcr1220115277 ◽  
Author(s):  
B. Etschmann ◽  
G. Krombach ◽  
A. Boning ◽  
S. Gattenlohner
Keyword(s):  
Cardiac Myxoma ◽  
High Grade ◽  
High Grade Sarcoma

scholarly journals HIGH GRADE SARCOMA WITH MYXOID FEATURES

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1542-A1543
Author(s):  
Kenneth Mueller ◽  
Alheli Arce Gastelum ◽  
Jared Alberts ◽  
Paul Millner ◽  
Zachary DePew
Keyword(s):  
High Grade ◽  
High Grade Sarcoma

scholarly journals Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Richard A. Peterson ◽  
Bhavani Kashyap ◽  
Pamala A. Pawloski ◽  
Anna C. Forsberg ◽  
Leah R. Hanson
Keyword(s):  
Radiation Therapy ◽  
Genetic Predisposition ◽  
Radiation Treatment ◽  
Tumor Resection ◽  
Tp53 Gene ◽  
World Health ◽  
High Grade ◽  
Who Grade ◽  
Li Fraumeni Syndrome ◽  
High Grade Sarcoma

Radiation-induced sarcomas in the brain are extremely rare, usually occur with an average latency of 9 years, and are associated with poor outcomes. Latency periods shorter than 1 year may indicate a genetic predisposition such as Li-Fraumeni syndrome. A 34-year-old man underwent initial tumor resection and radiation therapy for a World Health Organization (WHO) Grade II Astrocytoma. Within 6 months, the tumor recurred as WHO Grade III and was treated with temozolomide and then bevacizumab. Despite the patient’s apparent improving condition, MRI revealed new dural-based lesions 10 months after radiation therapy and identified as high-grade sarcoma. The patient resumed bevacizumab, began NovoTTF treatment for progressing glioma, and ifosfamide/doxorubicin for the sarcoma. Genetic testing revealed no pathogenic mutation in the TP53 gene. Ultimately, treatment was unsuccessful and the patient succumbed to glioma and sarcoma within 2 years of initial diagnosis. This case was unique due to the rapidly progressing glioma and sudden appearance of a high-grade sarcoma. It is unusual to have two separate intracranial primary cancers with each requiring a different chemotherapy regimen. We discuss the difficulty of simultaneously treating with separate chemotherapy regimens. It remains unclear whether the sarcoma was induced by the radiation treatment or a genetic predisposition.

Bone–Prosthesis Composite with Rotating Hinged-Knee Prosthesis in Limb Salvage Surgery for High-Grade Sarcoma Around the Knee

2015 ◽  
Vol 30 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Chien-Shun Wang ◽  
Po-Kuei Wu ◽  
Cheng-Fong Chen ◽  
Wei-Ming Chen ◽  
Chien-Lin Liu ◽  
...  
Keyword(s):  
Limb Salvage ◽  
Salvage Surgery ◽  
Knee Prosthesis ◽  
Limb Salvage Surgery ◽  
High Grade ◽  
High Grade Sarcoma
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