High-grade Sarcoma Masquerading as Growing Teratoma Syndrome After Resection of Ovarian Immature Teratoma

2012 ◽  
Vol 31 (3) ◽  
pp. 276-279 ◽  
Author(s):  
Elizabeth G. Morency ◽  
Dimitry Lerner ◽  
Roberto Garcia ◽  
Tamara Kalir
Keyword(s):  
Immature Teratoma ◽  
High Grade ◽  
Growing Teratoma Syndrome ◽  
High Grade Sarcoma

scholarly journals High-Grade Sarcoma Arising in the Background of Growing Teratoma Syndrome; A Rare Case

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S81-S82
Author(s):  
Q Sadiq ◽  
S Mohammed ◽  
N Yadak ◽  
F Khan
Keyword(s):  
Germ Cell ◽  
Tumor Cells ◽  
Germ Cell Tumor ◽  
Cell Tumor ◽  
High Grade ◽  
Growing Teratoma Syndrome ◽  
Peritoneal Implants ◽  
High Grade Sarcoma ◽  
History Of

Abstract Introduction/Objective Growing teratoma syndrome is a rare condition seen in patients with a history of immature teratomas or mixed germ cell tumor status post-treatment. It usually occurs within the first two years of diagnosis but rarely can be seen years later. Methods/Case Report We report a case of a 48-year-old female with a previous history of ovarian malignancy in adolescence status post-TAH/BSO and chemotherapy, now presenting with a 23 cm multi cystic septate mass with some solid components in the subdiaphragmatic area, extending into the liver on imaging. Nodular implants along the surface of the right hepatic lobe and multiple peritoneal implants were seen. Histology of peritoneal implants showed fibro adipose tissue admixed with rare scattered glandular elements, epithelial fragments, and mature neuroglial tissue, consistent with mature teratoma. Liver biopsy revealed short fascicles of spindled, epithelioid and rhabdoid tumor cells admixed with foci of the myxoid stroma. Scattered moderate cytologic atypia, atypical mitosis, and necrosis were appreciated. Tumor cells showed strong and diffuse reactivity to vimentin while being negative for epithelial, neural/mesenchymal, mesothelial, sex cord-stromal, and germ cell differentiation markers. Differential diagnostic considerations included spindle cell transformation of a germ cell tumor or high-grade sarcoma, not otherwise specified arising in the background of growing teratoma syndrome. FISH testing for isochromosome 12p was negative excluding sarcomatoid germ cell tumor. Results (if a Case Study enter NA) NA Conclusion This case study highlights the importance of considering the rare complication of high-grade sarcoma arising in the background of growing teratoma syndrome.

Acute Aortic Thromboembolism After Right Middle and Lower Bilobectomy for Metastatic High-Grade Sarcoma

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A37
Author(s):  
Adil Malik ◽  
Andrew Serdiuk ◽  
David Thrush ◽  
Evan Glazer ◽  
Puya Alikhani ◽  
...  
Keyword(s):  
High Grade ◽  
High Grade Sarcoma

scholarly journals Growing Teratoma Syndrome: Two case reports

2021 ◽  
Author(s):  
anju shrestha ◽  
Hari Dhakal ◽  
Sirish Pandey ◽  
Kapendra Amatya ◽  
Sudip Shrestha ◽  
...  
Keyword(s):  
Tumor Markers ◽  
Surgical Resection ◽  
Case Reports ◽  
Mature Teratoma ◽  
Immature Teratoma ◽  
Surgical Staging ◽  
Growing Teratoma Syndrome ◽  
Complete Surgical Resection

We present two cases of nine and twenty-seven years old girls with recurrence of immature teratoma after an incomplete surgical staging. In both cases, there were huge abdominopelvic masses despite decrease in tumor markers with chemotherapy. Complete surgical resection of these masses was done, and histopathology showed only mature teratoma.

scholarly journals Neoadjuvant concurrent chemoradiotherapy with and without hyperthermia in retroperitoneal and intra-abdominal sarcomas: Feasibility, efficacy, toxicity and long-term outcome

2021 ◽  
Author(s):  
Alexander Willner ◽  
Katja Fechner ◽  
Abbas Agaimy ◽  
Florian Haller ◽  
Markus Eckstein ◽  
...  
Keyword(s):  
Neoadjuvant Chemoradiotherapy ◽  
Tumor Control ◽  
High Grade ◽  
Regional Hyperthermia ◽  
Abdominal Tumor ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Free Survival ◽  
High Grade Sarcoma

Abstract Background Retroperitoneal (RPS) and intra-abdominal sarcomas (IAS) are associated with poor local and abdominal tumor control. Yet, the benefit of preoperative radio- or chemotherapy alone for these entities currently is unclear. Moreover, as intermediate- and high-grade sarcomas have a tendency for early metastasis, exploration of neoadjuvant strategies is of high importance. This analysis reports the results of our 20-year single-institution experience with preoperative neoadjuvant concurrent chemoradiation.Methods From 2000-2019, 27 patients with intermediate- or high-grade RPS or IAS (12 dedifferentiated liposarcoma, 10 leiomyosarcoma, 5 others) were treated with radiotherapy (median dose: 50.4 Gy; range 45-75 Gy) and two cycles of chemotherapy (doxorubicin 50mg/m² BSA/d3 q28 and ifosfamide 1.5g/m2 BSA/d1-5 q28) in neoadjuvant intention. Chemotherapy consisted of doxorubicin alone in two cases and ifosfamide alone in one case. Fifteen patients (56%) received deep regional hyperthermia additionally.Results The median follow-up time was 53 months (± 56.7 months). 92% of patients received two cycles of chemotherapy as planned and 92% underwent surgery. At 5 and 10 years, abdominal-recurrence-free-survival was 74.6% (± 10.1%) and 66.3% (± 11.9%), distant-metastasis-free-survival was 67.2% (± 9.7%) and 59.7% (± 11.1%), and overall-survival was 60.3% (± 10.5%) and 60.3% (± 10.5%), respectively. CTC grade III and IV toxicities were leukocytopenia (85%), thrombocytopenia (33%) and anemia (11%). There were no treatment-related deaths.Conclusions Neoadjuvant chemoradiotherapy with and without hyperthermia for retroperitoneal and intra-abdominal sarcoma is feasible and provided high local control of intermediate - and high-grade sarcoma.

Emergence of a High-Grade Sarcoma in a Recurrent Meningioma: Malignant Progression or Collision Tumor?

2011 ◽  
Vol 135 (7) ◽  
pp. 935-940
Author(s):  
Buge Oz ◽  
Melike Pekmezci ◽  
Reza Dashti ◽  
Kutlay Karaman ◽  
Cengiz Kuday ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Neurofibromatosis Type ◽  
Collision Tumor ◽  
World Health ◽  
Malignant Neoplasms ◽  
High Grade ◽  
Multiple Meningiomas ◽  
Short Period ◽  
High Grade Sarcoma ◽  
Health Organization

Abstract Anaplastic meningiomas that resemble sarcomas often reveal clues to their meningothelial differentiation or develop in a plausible setting that confirms their meningothelial origin. Malignant mesenchymal neoplasms without obvious evidence of meningothelial differentiation or origin are more likely to be true primary or metastatic sarcomas. Because of their clinical and biological differences, it is important to distinguish anaplastic meningioma from a sarcoma. We present a 67-year-old woman with multiple meningiomas, who developed a high-grade spindle cell tumor 6 months after the resection of a World Health Organization grade I meningioma. It was not clear whether this tumor represented a malignant transformation of meningioma or a primary sarcoma. Malignant transformation of a meningioma is exceptional within this short period and a coexisting sarcoma and meningioma are equally uncommon. Even though these malignant neoplasms are rare in general, they appear to be more prevalent in patients with multiple meningiomas including those with neurofibromatosis type 2.

scholarly journals RASAL2-RET: a novel RET rearrangement in a patient with high-grade sarcoma of the chest

2020 ◽  
Vol 31 (5) ◽  
pp. 659-661
Author(s):  
Y. Zhou ◽  
C. Qi ◽  
M.Z. Xiao ◽  
S.L. Cai ◽  
B.J. Chen
Keyword(s):  
High Grade ◽  
High Grade Sarcoma ◽  
Ret Rearrangement

scholarly journals Pleomorphic high-grade sarcoma of the heart mimicking cardiac myxoma

2012 ◽  
Vol 2012 (mar08 1) ◽  
pp. bcr1220115277-bcr1220115277 ◽  
Author(s):  
B. Etschmann ◽  
G. Krombach ◽  
A. Boning ◽  
S. Gattenlohner
Keyword(s):  
Cardiac Myxoma ◽  
High Grade ◽  
High Grade Sarcoma

scholarly journals HIGH GRADE SARCOMA WITH MYXOID FEATURES

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1542-A1543
Author(s):  
Kenneth Mueller ◽  
Alheli Arce Gastelum ◽  
Jared Alberts ◽  
Paul Millner ◽  
Zachary DePew
Keyword(s):  
High Grade ◽  
High Grade Sarcoma
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