Faculty Opinions recommendation of TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.

2002 ◽  
Author(s):  
Roger Hardie
Keyword(s):  
Cell Membrane ◽  
Membrane Depolarization ◽  
Cation Channel ◽  
Nonselective Cation Channel

scholarly journals TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization

Cell ◽  
2002 ◽  
Vol 109 (3) ◽  
pp. 397-407 ◽  
Author(s):  
Pierre Launay ◽  
Andrea Fleig ◽  
Anne-Laure Perraud ◽  
Andrew M. Scharenberg ◽  
Reinhold Penner ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Membrane Depolarization ◽  
Cation Channel ◽  
Nonselective Cation Channel

P-Glycoprotein Contributes to Cell Membrane Depolarization of Hippocampus and Neocortex in a Model of Repetitive Seizures Induced by Pentylenetetrazole in Rats

2013 ◽  
Vol 19 (38) ◽  
pp. 6732-6738 ◽  
Author(s):  
Jerónimo A. Auzmendi ◽  
Sandra Orozco-Suárez ◽  
Ivette Bañuelos-Cabrera ◽  
María Eva González-Trujano ◽  
Eduardo Calixto González ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Membrane Depolarization ◽  
P Glycoprotein

scholarly journals TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells

2007 ◽  
Vol 73 (3) ◽  
pp. 531-538 ◽  
Author(s):  
M DEMION ◽  
P BOIS ◽  
P LAUNAY ◽  
R GUINAMARD
Keyword(s):  
Cation Channel ◽  
Nonselective Cation Channel

scholarly journals Nonselective cation channel function in sheep pulmonary arteries is affected by postnatal maturation and chronic hypoxia

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Demosthenes G Papamatheakis ◽  
Srilakshmi Vemulakonda ◽  
Quintin Blood ◽  
Travis T Merritt ◽  
Sidney Lauw ◽  
...  
Keyword(s):  
Chronic Hypoxia ◽  
Pulmonary Arteries ◽  
Cation Channel ◽  
Nonselective Cation Channel ◽  
Postnatal Maturation ◽  
Channel Function

Ca(2+)-activated nonselective cation channel in apical membrane of vestibular dark cells

1992 ◽  
Vol 262 (6) ◽  
pp. C1423-C1429 ◽  
Author(s):  
D. C. Marcus ◽  
S. Takeuchi ◽  
P. Wangemann
Keyword(s):  
Single Channel ◽  
Apical Membrane ◽  
Cation Channel ◽  
Nonselective Cation Channel ◽  
Channel Activity ◽  
Dark Cells ◽  
Linear Current ◽  
Current Voltage ◽  
K Secretion ◽  
Vestibular Dark Cells

Patch-clamp recordings were made on cell-attached and excised apical membrane from dark cells of the semicircular canal of the gerbil. These cells are thought to secrete K+ and absorb Na+ from the luminal fluid (endolymph). Single-channel events were identified as being equally conductive (27.6 +/- 0.4 pS; n = 48) for K+, Na+, Rb+, Li+, and Cs+ and 1.4 times more permeable to NH4+ but not permeable to Cl-, Ca2+, Ba2+, nor to N-methyl-D-glucamine. The channels displayed linear current-voltage relations that passed nearly through the origin (intercept: -2.6 +/- 0.5 mV; n = 48) when conductive monovalent cations were present on both sides of the membrane in equal concentrations. Channel activity required the presence of Ca2+ at the cytosolic face; there was no activity at less than or equal to 10(-7) M Ca2+ and full activity at greater than or equal to 10(-5) M Ca2+. Cell-attached recordings had a mean reversal voltage of -36.4 +/- 7.9 mV (n = 7), which was interpreted to reflect the intracellular potential of dark cells under the present conditions. We have identified a nonselective cation channel in the apical membrane of vestibular dark cells that might participate in K+ secretion or Na+ absorption under stimulated conditions, but the density appears to be insufficient to fully account for the transepithelial K+ flux.

scholarly journals Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6

2019 ◽  
Vol 294 (34) ◽  
pp. 12655-12669 ◽  
Author(s):  
Brianna E. Talbot ◽  
David H. Vandorpe ◽  
Brian R. Stotter ◽  
Seth L. Alper ◽  
Johannes S. Schlondorff
Keyword(s):  
Cation Channel ◽  
Nonselective Cation Channel
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