Faculty Opinions recommendation of Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells.

2003 ◽  
Author(s):  
Jeffrey Bluestone
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Immature Dendritic Cells

scholarly journals Immature dendritic cells convert anergic nonregulatory T cells into Foxp3−IL-10+regulatory T cells by engaging CD28 and CTLA-4

2014 ◽  
Vol 45 (2) ◽  
pp. 480-491 ◽  
Author(s):  
Katrien Pletinckx ◽  
Martin Vaeth ◽  
Theresa Schneider ◽  
Niklas Beyersdorf ◽  
Thomas Hünig ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Immature Dendritic Cells

scholarly journals Immunosuppression induced by immature dendritic cells is mediated by TGF-β/IL-10 double-positive CD4+regulatory T cells

2008 ◽  
Vol 12 (2) ◽  
pp. 690-700 ◽  
Author(s):  
N. Cools ◽  
V.F.I. Van Tendeloo ◽  
E.L.J.M. Smits ◽  
M. Lenjou ◽  
G. Nijs ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Double Positive ◽  
Immature Dendritic Cells

Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans

Blood ◽  
2002 ◽  
Vol 100 (1) ◽  
pp. 174-177 ◽  
Author(s):  
Madhav V. Dhodapkar ◽  
Ralph M. Steinman
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Cd8 T Cells ◽  
Cell Function ◽  
Human Subjects ◽  
Interferon Γ ◽  
Healthy Human ◽  
Immature Dendritic Cells

Abstract Regulatory T cells (TRs) can suppress the function of other effector T cells in the setting of autoimmunity, transplantation, and resistance to tumors. The mechanism for the induction of TRs has not been defined. We previously reported that an injection of immature dendritic cells (DCs) pulsed with influenza matrix peptide (MP) led 7 days later to antigen-specific silencing of effector T-cell function in the blood of 2 healthy human subjects. Here, we found that interferon-γ–producing effectors return by 6 months. Importantly, in mixing experiments, CD8+ T cells from the sample obtained 7 days after injection could suppress MP-specific effectors obtained before injection and those in recovery samples. This suppression or regulation was specific for the immunizing peptide (MP) and cell-dose dependent, and it required contact between the 2 samples. These data show the capacity of immature DCs to induce antigen-specific regulatory CD8+ T cells in humans.

Increased α2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells

2006 ◽  
Vol 34 (9) ◽  
pp. 1211-1217 ◽  
Author(s):  
Jutta Jenner ◽  
Gunter Kerst ◽  
Rupert Handgretinger ◽  
Ingo Müller
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Surface Proteins ◽  
Immature Dendritic Cells

scholarly journals Immature Dendritic Cells Suppress Collagen-Induced Arthritis by In Vivo Expansion of CD49b+ Regulatory T Cells

2006 ◽  
Vol 177 (6) ◽  
pp. 3806-3813 ◽  
Author(s):  
Louis-Marie Charbonnier ◽  
Leonie M. van Duivenvoorde ◽  
Florence Apparailly ◽  
Céline Cantos ◽  
Wanda G. H. Han ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Collagen Induced Arthritis ◽  
Immature Dendritic Cells
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