Faculty Opinions recommendation of Structure of a ternary transcription activation complex.

2004 ◽  
Author(s):  
Richard Gourse
Keyword(s):  
Transcription Activation

scholarly journals Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

1994 ◽  
Vol 269 (11) ◽  
pp. 8268-8279
Author(s):  
Y. Miyagoe ◽  
M.D. Galibert ◽  
E. Georgatsou ◽  
G. Fourel ◽  
T. Meo
Keyword(s):  
Transcription Activation ◽  
Start Site ◽  
Site Location ◽  
Promoter Elements ◽  
Complement C4

scholarly journals KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis

2021 ◽  
pp. 1-12
Author(s):  
Isatou Bah ◽  
Tuqa Alkhateeb ◽  
Dima Youssef ◽  
Zhi Q. Yao ◽  
Charles E. McCall ◽  
...  
Keyword(s):  
Suppressor Cells ◽  
Transcription Activation ◽  
Myeloid Derived Suppressor Cells ◽  
Molecular Processes ◽  
Epigenetic Switch ◽  
Translation Research ◽  
Non Coding Rna ◽  
Genetic Deletion ◽  
Lysine Demethylase ◽  
Long Non Coding Rna

Sepsis-induced myeloid-derived suppressor cells (MDSCs) increase mortality risk. We previously identified that long non-coding RNA Hotairm1 supports myeloid precursor shifts to Gr1<sup>+</sup>CD11b<sup>+</sup> MDSCs during mouse sepsis. A major unanswered question is what molecular processes control Hotairm1 expression. In this study, we found by a genetic deletion that a specific PU.1-binding site is indispensable in controlling Hotairm1 transcription. We then identified H3K4me3 and H3K27me3 at the PU.1 site on the Hotairm1 promoter. Controlling an epigenetic switch of Hotairm1 transcription by PU.1 was histone KDM6A demethylase for H3K27me3 that derepressed its transcription with possible contributions from Ezh2 methyltransferase for H3K27me3. KDM6A knockdown in MDSCs increased H3K27me3, decreased H3K4me3, and inhibited Hotairm1 transcription activation by PU.1. These results enlighten clinical translation research of PU.1 epigenetic regulation as a potential sepsis immune-checkpoint treatment site.

scholarly journals Structural basis of CueR-dependent transcription activation

iScience ◽  
2021 ◽  
pp. 102449
Author(s):  
Wei Shi ◽  
Baoyue Zhang ◽  
Yanan Jiang ◽  
Chang Liu ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Transcription Activation ◽  
Structural Basis
Sign in / Sign up

Export Citation Format

Share Document