Faculty Opinions recommendation of Robust temporal coding in the trigeminal system.

Author(s):  
Leonard Maler
Science ◽  
2004 ◽  
Vol 304 (5679) ◽  
pp. 1986-1989 ◽  
Author(s):  
L. M. Jones

1995 ◽  
Vol 5 (10) ◽  
pp. 1367-1374
Author(s):  
S. M. Gerasyuta ◽  
D. V. Ivanov

2019 ◽  
Author(s):  
Robert Pellegrino ◽  
Curtis Luckett

Chemesthesis, along with taste and olfaction, is a primary component of flavor that engages the trigeminal system through specific chemical binding. For instance, many gums or confectionaries incorporate chemical cooling agents, such as Wilkinson Sword (WS) compounds, to create the sensation of coldness. The current study was designed to evaluate crossmodal associations of color and aroma with the chemesthetic perception of cooling. A “minty” and non-odorized set of confectionary stimuli, colored green, blue or white, with moderate cooling properties (with WS-3) were used in this study. In the first session, participants were randomly presented a stimuli and asked to rate several attributes including its cooling intensity on a generalized Labeled Magnitude Scale (gLMS). In the second session, the same participants were asked to relate cooling levels to different colors and which color relates to the “minty” odor. Additionally, open-ended reasons were given for association choices. Appearance and odor influenced the intensity of cooling sensation. In particular, the odorized and blue samples were rated as cooler than the non-odorized and other colored samples, respectively. The follow-up session confirms blue as a color associated with cooling properties, especially cool objects/abstract concepts. Meanwhile, odor’s enhancement on cooling sensation may be more perceptual in nature through affective matching from enhanced flavor.


2021 ◽  
Author(s):  
Louis‐Marie Terrier ◽  
Nouchine Hadjikhani ◽  
Stéphane Velut ◽  
Caroline Magnain ◽  
Aymeric Amelot ◽  
...  
Keyword(s):  

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Eder Gambeta ◽  
Maria A. Gandini ◽  
Ivana A. Souza ◽  
Laurent Ferron ◽  
Gerald W. Zamponi

AbstractA novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia. This mutation leads to a substitution of proline 2455 by histidine (P2455H) in the distal C-terminus region of the channel. Due to the well characterized role of this channel in neurotransmitter release, our aim was to characterize the biophysical properties of the P2455H variant in heterologously expressed CaV2.1 channels. Whole-cell patch clamp recordings of wild type and mutant CaV2.1 channels expressed in tsA-201 cells reveal that the mutation mediates a depolarizing shift in the voltage-dependence of activation and inactivation. Moreover, the P2455H mutant strongly reduced calcium-dependent inactivation of the channel that is consistent with an overall gain of function. Hence, the P2455H CaV2.1 missense mutation alters the gating properties of the channel, suggesting that associated changes in CaV2.1-dependent synaptic communication in the trigeminal system may contribute to the development of trigeminal neuralgia.


1998 ◽  
Vol 18 (16) ◽  
pp. 6583-6598 ◽  
Author(s):  
Ferenc Mechler ◽  
Jonathan D. Victor ◽  
Keith P. Purpura ◽  
Robert Shapley

2008 ◽  
Vol 71 (16-18) ◽  
pp. 3379-3386 ◽  
Author(s):  
Daichi Kimura ◽  
Yoshinori Hayakawa

Sign in / Sign up

Export Citation Format

Share Document