Seashells and Oyster Shells: Biobased Fine Aggregates in Concrete Mixtures

The construction industry is the largest global consumer of materials, among which sand plays a fundamental role; now the second most used natural resource behind water, sand is the primary component in concrete. However, natural sand production is a slow process and sand is now consumed at a faster pace than it’s replenished. One way to reduce consumption of sand is to use alternative materials in the concrete industry. This paper reports the exploratory study on the suitability of aquaculture byproducts as fine aggregates in concrete mixtures. Seashell grit, seashell flour and oyster flour were used as sand replacements in concrete mixtures (10%, 30% and 50% substitution rates). All the mixtures were characterized in fresh and hardened states (workability, air content, compressive strength and water absorption). Based on compressive strength, measured at 7 and 28 days, seashell grit provided the most promising results: the compressive strength was found to be larger than for conventional concrete. Moreover, the compressive strength of the cubes was larger, when larger percentages of seashell grit were used, with the highest value obtained for 50% substitution. However, for oyster flour and seashell flour, only 10% sand substitution provided results comparable with the control mixture. For the three aggregates, workability of concrete decreases with fineness modulus decrease. For mixtures in which shell and oyster flour were used with 30% and 50% substitution percentages, it was necessary to increase the quantity of mixing water to allow a minimal workability. In conclusion, considering the promising results of the seashell grit, it is suggested to study further the characteristic of the material, also considering its environmental and physical properties, including acoustic and thermal performances. Higher substitution percentages should also be investigated. This research adds to the relevant literature in matter of biobased concrete, aiming at finding new biobased sustainable alternatives in the concrete industry.

The first photometric analysis of two low mass ratio totally eclipsing contact binaries: TIC 393943031 and TIC 89428764

PhotometricanalysisofthecontactbinariesTIC393943031andTIC89428764was carried out usingTESS and SuperWASP data for the first time. Using Wilson-Devinneycode, we have discovered TIC 393943031 is a low-mass-ratio deep contact binary with a fillout factor of 50.9(±1)% and a mass ratio of q = 0.163 ± 0.001. TIC 89428764 is a medium and low-mass-ratio contact binary with a fillout factor of 34.5(±1)% and a mass ratio of q = 0.147±0.001. Furthermore, the period study reveals both the stars exhibit continuously increasing periods, the increasing rate is 4.21×10−7day ·year−1for TIC 393943031while 6.36 × 10−7day · year−1for TIC 89428764. The possible reason is mass transfer from the secondary component to the primary component for both the stars. Meanwhile, we discussed their evolutionary phases and orbital angular momenta.

Metabolic Processing of Selenium-based Bioisostere of meso-diaminopimelic Acid in Live Bacteria

The bacterial cell wall supports cell shape and prevents lysis due to internal turgor pressure. A primary component of all known bacterial cell walls is the peptidoglycan (PG) layer, which is comprised of repeating units of sugars connected to short and unusual peptides. The various steps within PG biosynthesis are often the target of antibiotics as they are essential for cellular growth and survival. Synthetic mimics of PG have proven to be indispensable tools to study bacterial cell growth and remodeling. Yet, a common component of PG, meso-diaminopimelic acid (m-DAP) at the third position of the stem peptide, remains challenging to build synthetically and is not commercially available. Here, we describe the synthesis and metabolic processing of a selenium-based bioisostere of a m-DAP analogue, selenolanthionine. We show that selenolanthionine is installed within the PG of live bacteria by the native cell wall crosslinking machinery in several mycobacteria species. We envision that this probe will supplement the current methods available for investigating PG crosslinking in m-DAP containing organisms.

Hsp40s play distinct roles during the initial stages of apolipoprotein B biogenesis

Apolipoprotein B (ApoB) is the primary component of atherogenic lipoproteins, which transport serum fats and cholesterol. Therefore, elevated levels of circulating ApoB are a primary risk factor for cardiovascular disease. During ApoB biosynthesis in the liver and small intestine under nutrient-rich conditions, ApoB cotranslationally translocates into the endoplasmic reticulum (ER) and is lipidated and ultimately secreted. Under lipid-poor conditions, ApoB is targeted for ER Associated Degradation (ERAD). Although prior work identified select chaperones that regulate ApoB biogenesis, the contributions of cytoplasmic Hsp40s are undefined. To this end, we screened ApoB-expressing yeast and determined that a class A ER-associated Hsp40, Ydj1, associates with and facilitates the ERAD of ApoB. Consistent with these results, a homologous Hsp40, DNAJA1, functioned similarly in rat hepatoma cells. DNAJA1 deficient cells also secreted hyperlipidated lipoproteins, in accordance with attenuated ERAD. In contrast to the role of DNAJA1 during ERAD, DNAJB1—a class B Hsp40—helped stabilize ApoB. Depletion of DNAJA1 and DNAJB1 also led to opposing effects on ApoB ubiquitination. These data represent the first example in which different Hsp40s exhibit disparate effects during regulated protein biogenesis in the ER, and highlight distinct roles that chaperones can play on a single ERAD substrate.

Implication of Buteyko Breathing Technique in Asthmatic Population: A Literature Review

Background: Complementary and experimental medicine is gaining interest in the treatment of asthma around the world. This study summarizes the literature on complementary and alternative medicine approaches that use breathing retraining, i.e Buteyko breathing technique (BBT) as a primary component. Aim: The aim of this research is to provide background for BBT, analyse the available evidence for its efficacy and evaluate the physiological framework behind it. Methods: The analysis of literature is carried out by studying papers from electronic databases such as Cochrane, Medline, Embase, AMED, PEDro, Google Scholar, Elsevier, APTA, Campbell, Web of Science, and Research Gate. Conclusion: Individual studies using BBT consistently showed a reduction in asthma medication use. In either of the BBT experiments, no significant difference in lung ability was found. BBT detractors argue that drug reduction can be due to the physicians' influence, which is difficult to determine. Longer follow-up is needed to show that the improvement in asthma treatment as measured by drug usage is sustained over a clinically appropriate time span.

A “Hired Girl” Testifies Against the “Son of a Prominent Family”: Bastardy and Rape on the Nineteenth-Century Nebraska Plains

In Red Cloud, Nebraska, in 1887, Anna “Annie” Sadilek (later Pavelka) pressed bastardy charges against the “son of a prominent family,” even though she could have, according to her pre-trial testimony, pressed charges for rape. To the literary world, Sadilek is better known as Ántonia Shimerda, the powerful protagonist in Willa Cather’s 1918 novel, My Ántonia. However, it is Sadilek’s real-life experience that allows us to better understand life on the Nebraska Plains, specifically through an examination of the state’s rape laws and the ways these laws were subsequently interpreted by the courts. The Nebraska Supreme Court, between 1877 and 1886, established the need for the state to prove force as a primary component of the definition for rape, drew boundaries around acceptable reporting times, and solidified their stance on the requirement of corroborating testimony. These factors led Sadilek to charge Charley Kaley not with rape but with bastardy, a civil suit, which almost guaranteed a successful outcome for Sadilek and her child because it would not burden the county or state with their financial welfare. In analyzing Sadilek’s choices before the law, this article demonstrates the complexities of the gendered legal systems facing women like Sadilek who sought justice for crimes of a sexual nature. Additionally significant, this article draws attention to a space and place that lacks significant study in regard to the sexual power dynamics of the nineteenth-century Great Plains West, a multicultural contact zone highly susceptible to the influences of hypermasculine control.

Bioheat Transfer Basis of Human Thermoregulation: Principles and Applications

Thermoregulation is a process that is essential to the maintenance of life for all warm-blooded mammalian and avian species. It sustains a constant core body temperature in the face of a wide array of environmental thermal conditions and intensity of physical activities that generate internal heat. A primary component of thermoregulatory function is the movement of heat between the body core and the surface via the circulation of blood. The peripheral vasculature acts as a forced convection heat exchanger between blood and local peripheral tissues enabling heat to be conducted to the skin surface where is may be transferred to and from the environment via conduction, convection, radiation, and/or evaporation of water as local conditions dictate. Humans have evolved a particular vascular structure in glabrous (hairless) skin that is especially well suited for heat exchange. These vessels are called arteriovenous anastomoses (AVAs) and can vasodilate to large diameters and accommodate high flow rates. We report herein a new technology based on a physiological principle that enables simple and safe access to the thermoregulatory control system that allow manipulation of thermoregulatory function. The technology operates by applying a small amount of heating local to control tissue on the body surface overlying the cerebral spine that upregulates AVA perfusion. Under this action, heat exchangers can be applied to glabrous skin, preferably on the palms and soles, to alter the temperature of elevated blood flow prior to its return to the core. Therapeutic and prophylactic applications are discussed.

Indigenous Fishing Methods of the Moyon Tribe of Manipur (India) and Myanmar

Fishing is one of the main economic activities of the Moyon tribe living in Manipur (India), and Myanmar. For many centuries, Moyons used indigenous methods for fishing. However, in recent years, indiscriminate fishing using modern technologies has led to an ecological crisis which not only affected the ichthyofauna diversity but also affected the livelihood of individuals depending on fishing as well as the sustainability of the indigenous fishing methods. The paper explores the indigenous fishing techniques and practices of the Moyon tribe. The study adopted a qualitative-exploratory research method with ethnography as the primary component. Data were collected from on-site observations of fishing and discussions with the local Moyon population. The study revealed that indigenous fishing methods have become unsustainable due to misuse by the fishers. Another significant observation was the shift in fishing methods from traditional to modern (market) gears. The recently used fishing gears are a threat to the fish population, aquatic ecosystem, and indigenous knowledge of fishing crafts. The study concludes that unsustainable fishing by the Moyon tribe is connected with poverty and the lack of development and education.

Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases

As the primary component of elastic fibers, elastin plays an important role in maintaining the elasticity and tensile ability of cardiovascular, pulmonary and many other tissues and organs. Studies have shown that elastin expression is regulated by a variety of molecules that have positive and negative regulatory effects. However, the specific mechanism is unclear. Moreover, elastin is reportedly involved in the development and progression of many cardiovascular diseases through changes in its expression and structural modifications once deposited in the extracellular matrix. This review article summarizes the role of elastin in myocardial ischemia-reperfusion, atherosclerosis, and atrial fibrillation, with emphasis on the potential molecular regulatory mechanisms.

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.—A Bioactivity Guided Approach

Macleaya cordata (Willd.) R. Br. (M. cordata) is a perennial herb known for its chemotherapeutic properties, strong feeding additive, and potential antidiarrheal drug. Despite its therapeutic potentials, its clinical applications are hindered by an apparent lack of toxicity data. In this study, the toxic ingredients of this plant were investigated using a bioactivity-guided approach. Two compounds, protopine and allocryptopine, were purified and elucidated by LC-MS, 1H-NMR, and 13C-NMR. Protopine, a primary component in M. cordata, had an LD50 of 313.10 mg/kg i.e., which was considered toxic. An autopsy was performed on protopine-administered mice, and the histopathology of the kidney, liver, brain, heart, lung, and spleen was determined. Autopsy findings included hemorrhage in the respiratory system, lung congestion, and hemorrhage and edema in the parenchymatous organs (heart, liver, kidney, and brain). Histopathology confirmed the pathological changes in the brain, liver, and kidney. Protopine is one of the principal bioactive constituents of many phytopreparations used in veterinary and human medicine, such as Sangrovit and Iberogast. Our findings indicated that phytopreparations containing protopine might pose a serious health threat to humans and animals.