Faculty Opinions recommendation of Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021793.247709 ◽

2005 ◽

Author(s):

Philip Lowden

Keyword(s):

Crystal Structure ◽

Histone Deacetylase ◽

Hydroxamic Acid ◽

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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0404603101 ◽

2004 ◽

Vol 101 (42) ◽

pp. 15064-15069 ◽

Author(s):

A. Vannini ◽

C. Volpari ◽

G. Filocamo ◽

E. C. Casavola ◽

M. Brunetti ◽

...

Keyword(s):

Crystal Structure ◽

Histone Deacetylase ◽

Hydroxamic Acid ◽

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Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor 1 1Edited by I. Wilson

Journal of Molecular Biology ◽

10.1006/jmbi.2001.4953 ◽

2001 ◽

Vol 312 (4) ◽

pp. 743-751 ◽

Author(s):

Herbert Nar ◽

Karlheinz Werle ◽

Margit M.T Bauer ◽

Horst Dollinger ◽

Birgit Jung

Keyword(s):

Crystal Structure ◽

Hydroxamic Acid ◽

Human Macrophage ◽

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Suberoylanilide hydroxamic acid, a potent histone deacetylase inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes

Journal of Inorganic Biochemistry ◽

10.1016/j.jinorgbio.2011.03.003 ◽

2011 ◽

Vol 105 (6) ◽

pp. 763-769 ◽

Author(s):

Darren M. Griffith ◽

Béla Szőcs ◽

Tomás Keogh ◽

Kyrill Yu. Suponitsky ◽

Etelka Farkas ◽

...

Keyword(s):

Crystal Structure ◽

Solid State ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Hydroxamic Acid ◽

Suberoylanilide Hydroxamic Acid ◽

X Ray ◽

Deacetylase Inhibitor ◽

Solution Studies

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A Structural Insight into Hydroxamic Acid Based Histone Deacetylase Inhibitors for the Presence of Anticancer Activity

Current Medicinal Chemistry ◽

10.2174/09298673113209990191 ◽

2013 ◽

Vol 21 (23) ◽

pp. 2642-2664 ◽

Author(s):

H. Rajak ◽

A. Singh ◽

K. Raghuwanshi ◽

R. Kumar ◽

P.K. Dewangan ◽

...

Keyword(s):

Anticancer Activity ◽

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Structural Insight ◽

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Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

International Journal of Cancer ◽

10.1002/ijc.22558 ◽

2007 ◽

Vol 121 (3) ◽

pp. 656-665 ◽

Author(s):

Takashi Kumagai ◽

Naoki Wakimoto ◽

Dong Yin ◽

Sigal Gery ◽

Norihiko Kawamata ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Hydroxamic Acid ◽

Human Pancreatic Cancer ◽

Suberoylanilide Hydroxamic Acid ◽

Pancreatic Cancer Cells ◽

Deacetylase Inhibitor

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Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0608041104 ◽

2007 ◽

Vol 104 (11) ◽

pp. 4297-4302 ◽

Author(s):

L. Guo ◽

A. Han ◽

D. L. Bates ◽

J. Cao ◽

L. Chen

Keyword(s):

Crystal Structure ◽

Histone Deacetylase ◽

Terminal Domain ◽

Histone Deacetylase 4

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Novel β-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01052 ◽

2015 ◽

Vol 58 (23) ◽

pp. 9214-9227 ◽

Author(s):

Yong Ling ◽

Chenjun Xu ◽

Lin Luo ◽

Jingyi Cao ◽

Jiao Feng ◽

...

Keyword(s):

Anticancer Activity ◽

Signaling Pathway ◽

Histone Deacetylase ◽

Hydroxamic Acid ◽

P53 Signaling ◽

P53 Signaling Pathway

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Treatment of canine haemangiosarcoma with suberoylanilide hydroxamic acid, a histone deacetylase inhibitor

Veterinary and Comparative Oncology ◽

10.1111/j.1476-5810.2004.00057.x ◽

2004 ◽

Vol 2 (4) ◽

pp. 243-248 ◽

Author(s):

L. A. Cohen ◽

B. Powers ◽

S. Amin ◽

D. Desai

Keyword(s):

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Hydroxamic Acid ◽

Suberoylanilide Hydroxamic Acid ◽

Deacetylase Inhibitor

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synthesis-and-evaluation-of-novel-hydroxamic-acid-based-histone-deacetylase-inhibitors-as-anti-cancer-agents/#

10.31038/cst.2017223 ◽

2017 ◽

Vol 2 (2) ◽

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

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Application of a Novel Collector DXS in Cassiterite Flotation

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.826.14 ◽

2013 ◽

Vol 826 ◽

pp. 14-19

Author(s):

Yi Min Zhu ◽

Yan Ping Yang ◽

Wen Dan Wang ◽

Yan Feng Li ◽

Duo Zhen Ren ◽

...

Keyword(s):

Crystal Structure ◽

Infrared Spectroscopy ◽

Carboxylic Acid ◽

Comparative Study ◽

Hydroxamic Acid ◽

Spectroscopy Analysis ◽

Adsorption Mechanisms ◽

Before And After ◽

The Relationship

A comparative study on the collecting effect to cassiterite was studied using a new carboxylic acid modified collector DXS and traditional collector salicylaldehyde hydroxamic acid as collectors, respectively. In addition, the relationship between floatability of DXS and crystal structure of cassiterite was investigated. By means of infrared spectroscopy analysis of the cassiterite surface before and after adsorbing DXS molecules, the adsorption mechanisms of DXS on the surface of cassiterite were analyzed.Keywords: carboxylic acid modified collector DXS; cassiterite; flotation mechanism

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