Faculty Opinions recommendation of Role of delayed nonsynaptic neuronal plasticity in long-term associative memory.

Author(s):  
Randolf Menzel
2006 ◽  
Vol 16 (13) ◽  
pp. 1269-1279 ◽  
Author(s):  
Ildikó Kemenes ◽  
Volko A. Straub ◽  
Eugeny S. Nikitin ◽  
Kevin Staras ◽  
Michael O'Shea ◽  
...  

2012 ◽  
Vol 13 (1) ◽  
pp. 103 ◽  
Author(s):  
Shawn N Watson ◽  
Tara E Risling ◽  
Petra M Hermann ◽  
Willem C Wildering

2020 ◽  
Vol 21 (16) ◽  
pp. 5624 ◽  
Author(s):  
Chiara Falcicchia ◽  
Francesca Tozzi ◽  
Ottavio Arancio ◽  
Daniel Martin Watterson ◽  
Nicola Origlia

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD). However, p38 MAPK is classically known as a responsive element to stress stimuli, including neuroinflammation. Specific to the pathophysiology of Alzheimer’s disease (AD), several studies have shown that the p38 MAPK cascade is activated either in response to the Aβ peptide or in the presence of tauopathies. Here, we describe the role of p38 MAPK in the regulation of synaptic plasticity and its implication in an animal model of neurodegeneration. In particular, recent evidence suggests the p38 MAPK α isoform as a potential neurotherapeutic target, and specific inhibitors have been developed and have proven to be effective in ameliorating synaptic and memory deficits in AD mouse models.


2013 ◽  
Author(s):  
Francesca Menegazzo ◽  
Melissa Rosa Rizzotto ◽  
Martina Bua ◽  
Luisa Pinello ◽  
Elisabetta Tono ◽  
...  

2014 ◽  
pp. 30-52 ◽  
Author(s):  
L. Grigoryev ◽  
E. Buryak ◽  
A. Golyashev

The Ukrainian socio-economic crisis has been developing for years and resulted in the open socio-political turmoil and armed conflict. The Ukrainian population didn’t meet objectives of the post-Soviet transformation, and people were disillusioned for years, losing trust in the state and the Future. The role of workers’ remittances in the Ukrainian economy is underestimated, since the personal consumption and stability depend strongly on them. Social inequality, oligarchic control of key national assets contributed to instability as well as regional disparity, aggravated by identity differences. Economic growth is slow due to a long-term underinvestment, and prospects of improvement are dependent on some difficult institutional reforms, macro stability, open external markets and the elites’ consensus. Recovering after socio-economic and political crisis will need not merely time, but also governance quality improvement, institutions reform, the investment climate revival - that can be attributed as the second transformation in Ukraine.


2006 ◽  
pp. 4-19 ◽  
Author(s):  
L. Abalkin

The article covers unified issues of the long-term strategy development, the role of science as well as democracy development in present-day Russia. The problems of budget proficit, the Stabilization Fund issues, implementation of the adopted national projects, an increasing role of regions in strengthening the integrity and prosperity of the country are analyzed. The author reveals that the protection of businessmen and citizens from the all-embracing power of bureaucrats is the crucial condition of democratization of the society. Global trends of the world development and expert functions of the Russian science are presented as well.


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