Faculty Opinions recommendation of Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer).

Author(s):  
Richard Sampliner

Endoscopy ◽  
2021 ◽  
Author(s):  
Jenny Krause ◽  
Thomas Rösch ◽  
Stefan Steurer ◽  
Till Clauditz ◽  
Susanne Sehner ◽  
...  

Background Following endoscopic resection of early-stage Barrett’s esophageal adenocarcinoma (BEA), further oncologic management then fundamentally relies upon the accurate assessment of histopathologic risk criteria, which requires there to be sufficient amounts of submucosal tissue in the resection specimens. Methods In 1685 digitized tissue sections from endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) performed for 76 early BEA cases from three experienced centers, the submucosal thickness was determined, using software developed in-house. Neoplastic lesions were manually annotated. Results No submucosa was seen in about a third of the entire resection area (mean 33.8 % [SD 17.2 %]), as well as underneath cancers (33.3 % [28.3 %]), with similar results for both resection methods and with respect to submucosal thickness. ESD results showed a greater variability between centers than EMR. In T1b cancers, a higher rate of submucosal defects tended to correlate with R1 resections. Conclusion The absence of submucosa underneath about one third of the tissue of endoscopically resected BEAs should be improved. Results were more center-dependent for ESD than for EMR. Submucosal defects can potentially serve as a parameter for standardized reports.



2020 ◽  
Vol 13 ◽  
pp. 263177452093524
Author(s):  
Oliver Pech ◽  
Saleh A. Alqahtani

Endoscopic therapy of early Barrett’s oesophagus–related neoplasia is the treatment of choice for low-grade-dysplasia, high-grade dysplasia and mucosal Barrett’s cancer. Low-grade-dysplasia without any visible lesion should be ablated, preferably with radiofrequency ablation. In cases with the presence of a visible lesion, high-grade dysplasia and early Barrett’s adenocarcinoma, endoscopic resection techniques like multiband ligation endoscopic resection or endoscopic submucosal dissection should be applied. After complete resection of all visible neoplastic lesions, ablation of the remaining Barrett’s oesophagus should be performed to prevent recurrence. Ablation techniques available are radiofrequency ablation, argon plasma coagulation and cryoablation.



2012 ◽  
Vol 75 (4) ◽  
pp. AB453-AB454
Author(s):  
Hendrik Manner ◽  
Oliver Pech ◽  
Andrea May ◽  
Juergen Pohl ◽  
Michael Vieth ◽  
...  


2005 ◽  
Vol 43 (05) ◽  
Author(s):  
O Pech ◽  
L Gossner ◽  
A May ◽  
J Huijsmans ◽  
C Ell






2011 ◽  
Vol 73 (4) ◽  
pp. AB146 ◽  
Author(s):  
Oliver Pech ◽  
Andrea May ◽  
Hendrik Manner ◽  
Juergen Pohl ◽  
Christian Ell


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