S1488: Histopathologic Features of Early Barrett's Cancer Invading the Submucosal Layer: Assessment of Endoscopic Resection Specimens in a Large Cohort of Patients

2010 ◽  
Vol 71 (5) ◽  
pp. AB175 ◽  
Author(s):  
Hendrik Manner ◽  
Oliver Pech ◽  
Christian Ell ◽  
Michael Vieth
Keyword(s):  
Endoscopic Resection ◽  
Large Cohort ◽  
Submucosal Layer ◽  
Barrett’S Cancer ◽  
Histopathologic Features

Quantitative analysis of submucosal excision depth in endoscopic resection for early Barrett’s cancer

Endoscopy ◽  
2021 ◽  
Author(s):  
Jenny Krause ◽  
Thomas Rösch ◽  
Stefan Steurer ◽  
Till Clauditz ◽  
Susanne Sehner ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Endoscopic Submucosal Dissection ◽  
Endoscopic Resection ◽  
Early Stage ◽  
Accurate Assessment ◽  
Tissue Sections ◽  
Barrett’S Cancer ◽  
Neoplastic Lesions ◽  
Resection Area ◽  
Barrett’S Esophageal Adenocarcinoma

Background Following endoscopic resection of early-stage Barrett’s esophageal adenocarcinoma (BEA), further oncologic management then fundamentally relies upon the accurate assessment of histopathologic risk criteria, which requires there to be sufficient amounts of submucosal tissue in the resection specimens. Methods In 1685 digitized tissue sections from endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) performed for 76 early BEA cases from three experienced centers, the submucosal thickness was determined, using software developed in-house. Neoplastic lesions were manually annotated. Results No submucosa was seen in about a third of the entire resection area (mean 33.8 % [SD 17.2 %]), as well as underneath cancers (33.3 % [28.3 %]), with similar results for both resection methods and with respect to submucosal thickness. ESD results showed a greater variability between centers than EMR. In T1b cancers, a higher rate of submucosal defects tended to correlate with R1 resections. Conclusion The absence of submucosa underneath about one third of the tissue of endoscopically resected BEAs should be improved. Results were more center-dependent for ESD than for EMR. Submucosal defects can potentially serve as a parameter for standardized reports.

EVALUATION OF RESULTS OF ENDOSCOPIC RESECTION OF MUCOSA BY DISSECTION IN SUBMUCOSA IN TREATMENT FOR EARLY GASTRIC CANCER

2017 ◽  
Vol 63 (2) ◽  
pp. 294-297
Author(s):  
Marina Grinkevich ◽  
Viktor Klimenko ◽  
Aleksandr Shcherbakov ◽  
Oleg Tkachenko
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Submucosal Layer ◽  
High Quality ◽  
Safe Method ◽  
Radical Treatment

The aim of the study was to evaluate the effectiveness of endoscopic resection of mucosa by dissection in submucosa in treatment for early gastric cancer. The study included 78 patients with early differentiated gastric cancer of stages T1aN0M0 (65) and T1bN0M0 (13) who underwent endoscopic resection of mucosa by dissection in the submucosal layer at the N.N. Petrov Research Institute of Oncology. According to results of our study endoscopic resection of mucosa by dissection in the submucosal layer in early gastric cancer is highly effective (98.7%) and is a relatively safe method of organ-preserving radical treatment with a high quality of life in the long-term period, which allows it to be recommended as an option of choice for this pathology.

scholarly journals Update on endoscopic treatment of Barrett’s oesophagus and Barrett’s oesophagus–related neoplasia

2020 ◽  
Vol 13 ◽  
pp. 263177452093524
Author(s):  
Oliver Pech ◽  
Saleh A. Alqahtani
Keyword(s):  
Radiofrequency Ablation ◽  
Endoscopic Resection ◽  
High Grade Dysplasia ◽  
Barrett’S Oesophagus ◽  
Low Grade ◽  
High Grade ◽  
Barrett's Oesophagus ◽  
Barrett’S Cancer ◽  
Visible Lesion ◽  
Low Grade Dysplasia

Endoscopic therapy of early Barrett’s oesophagus–related neoplasia is the treatment of choice for low-grade-dysplasia, high-grade dysplasia and mucosal Barrett’s cancer. Low-grade-dysplasia without any visible lesion should be ablated, preferably with radiofrequency ablation. In cases with the presence of a visible lesion, high-grade dysplasia and early Barrett’s adenocarcinoma, endoscopic resection techniques like multiband ligation endoscopic resection or endoscopic submucosal dissection should be applied. After complete resection of all visible neoplastic lesions, ablation of the remaining Barrett’s oesophagus should be performed to prevent recurrence. Ablation techniques available are radiofrequency ablation, argon plasma coagulation and cryoablation.

scholarly journals Histological Distinction between the Granular and Nongranular Types of Laterally Spreading Tumors of the Colorectum

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shingo P. Goto ◽  
Naoto Sakamoto ◽  
Hiroyuki Mitomi ◽  
Takashi Murakami ◽  
Hideaki Ritsuno ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Endoscopic Treatment ◽  
Previous Treatment ◽  
Vascular Density ◽  
Submucosal Layer ◽  
Muscularis Mucosae ◽  
Histological Features ◽  
Submucosal Fibrosis ◽  
Laterally Spreading Tumors

Colorectal laterally spreading tumors (LSTs), which are classified into granular (LST-G) and nongranular (LST-NG) types, are a good indication for endoscopic treatment. In practice, the nongranular type is more difficult to remove endoscopically than the granular type. It might be assumed that some histological differences exist between these subtypes. The objective of this study was to analyze histological features of laterally spreading tumors and compare between the granular and the nongranular types. A total of 32 cases of LSTs resected endoscopically being intramucosal tumors with no previous treatment were analyzed. The disposition of the muscularis mucosae, the vascular density, and the degree of fibrosis of the submucosal layer were determined. The outline of the muscularis mucosae in LST-NG was almost flat, but that of LST-G was wavy. The submucosal vascular density was significantly greater in the LST-NGs (61.4±24.3/mm2) than in the LST-Gs (43±22.4/mm2;P=0.033). There was no clear difference in the degree of submucosal fibrosis between the subtypes. A flat disposition of the muscularis mucosae and a more densely vascularized submucosal layer were characteristics of LST-NGs compared to the LST-Gs. These findings may play a role when performing the endoscopic resection of LSTs.

Tu1580 Early Barrett's Cancer With Incipient Submucosal Invasion (SM1): Results of Endoscopic Resection and Surgery

2012 ◽  
Vol 75 (4) ◽  
pp. AB453-AB454
Author(s):  
Hendrik Manner ◽  
Oliver Pech ◽  
Andrea May ◽  
Juergen Pohl ◽  
Michael Vieth ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Submucosal Invasion ◽  
Barrett’S Cancer

Curative endoscopic resection of early esophageal adenocarcinomas (Barrett’s cancer)

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
O Pech ◽  
L Gossner ◽  
A May ◽  
J Huijsmans ◽  
C Ell
Keyword(s):  
Endoscopic Resection ◽  
Barrett’S Cancer
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