Faculty Opinions recommendation of Synthetic macrolides that inhibit breast cancer cell migration in vitro.

2007 ◽  
Author(s):  
Dennis Hall
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration

scholarly journals Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Md Kamrul Hasan ◽  
George F. Widhopf ◽  
Suping Zhang ◽  
Sharon M. Lam ◽  
Zhouxin Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Surface Protein ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration ◽  
Promote Breast Cancer

Abstract ROR1 is a conserved oncoembryonic surface protein expressed in breast cancer. Here we report that ROR1 associates with cortactin in primary breast-cancer cells or in MCF7 transfected to express ROR1. Wnt5a also induced ROR1-dependent tyrosine phosphorylation of cortactin (Y421), which recruited ARHGEF1 to activate RhoA and promote breast-cancer-cell migration; such effects could be inhibited by cirmtuzumab, a humanized mAb specific for ROR1. Furthermore, treatment of mice bearing breast-cancer xenograft with cirmtuzumab inhibited cortactin phosphorylation in vivo and impaired metastatic development. We established that the proline at 841 of ROR1 was required for it to recruit cortactin and ARHGEF1, activate RhoA, and enhance breast-cancer-cell migration in vitro or development of metastases in vivo. Collectively, these studies demonstrate that the interaction of ROR1 with cortactin plays an important role in breast-cancer-cell migration and metastasis.

Synthetic Macrolides that Inhibit Breast Cancer Cell Migration in Vitro

2007 ◽  
Vol 129 (9) ◽  
pp. 2434-2435 ◽  
Author(s):  
Belhu B. Metaferia ◽  
Lin Chen ◽  
Heather L. Baker ◽  
Xin-Yun Huang ◽  
Carole A. Bewley
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration

scholarly journals Association between breast cancer cell migration and radiosensitivity in�vitro

2019 ◽  
Author(s):  
Jing Hou ◽  
Leilei Li ◽  
Haizhen Zhu ◽  
Huan Chen ◽  
Na Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration

scholarly journals Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro

2017 ◽  
Vol 66 (10) ◽  
pp. 1287-1294 ◽  
Author(s):  
Sarah J. Storr ◽  
Sabreena Safuan ◽  
Narmeen Ahmad ◽  
Mohammed El-Refaee ◽  
Andrew M. Jackson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Cancer Cell Migration ◽  
Human Breast ◽  
Breast Cancer Cell Migration

scholarly journals Development of JNK2-Selective Peptide Inhibitors That Inhibit Breast Cancer Cell Migration

2011 ◽  
Vol 6 (6) ◽  
pp. 658-666 ◽  
Author(s):  
Tamer S. Kaoud ◽  
Shreya Mitra ◽  
Sunbae Lee ◽  
Juliana Taliaferro ◽  
Michael Cantrell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Peptide Inhibitors ◽  
Cancer Cell Migration ◽  
Breast Cancer Cell Migration
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