Faculty Opinions recommendation of Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study.

2008 ◽  
Author(s):  
Zoltán Szekanecz ◽  
Zoltan Szabo
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Large Cohort ◽  
Age At Diagnosis ◽  
Leukocyte Antigen ◽  
Large Cohort Study ◽  
Autoantibody Status

Human leukocyte antigen-G polymorphism influences the age of onset and autoantibody status in rheumatoid arthritis

2015 ◽  
Vol 85 (3) ◽  
pp. 182-189 ◽  
Author(s):  
C. M. Mariaselvam ◽  
A. B. Chaaben ◽  
S. Salah ◽  
D. Charron ◽  
R. Krishnamoorthy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Human Leukocyte Antigen ◽  
Age Of Onset ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Autoantibody Status ◽  
Human Leukocyte Antigen G

scholarly journals Non-inherited maternal human leukocyte antigen alleles in susceptibility to familial rheumatoid arthritis

2008 ◽  
Vol 68 (1) ◽  
pp. 107-109 ◽  
Author(s):  
K A Guthrie ◽  
N R Tishkevich ◽  
J L Nelson
Keyword(s):  
Rheumatoid Arthritis ◽  
Human Leukocyte Antigen ◽  
Age Of Onset ◽  
Human Leukocyte ◽  
Paternal Allele ◽  
Hla Alleles ◽  
Leukocyte Antigen ◽  
The North ◽  
Significant Difference ◽  
Hla Genotype

Objectives:Some patients with rheumatoid arthritis (RA) lack RA-associated human leukocyte antigen (HLA) alleles. Prior studies investigated non-inherited maternal HLA alleles (NIMA) in RA risk with conflicting results.Methods:We examined NIMA in a large cohort of families from the North American Rheumatoid Arthritis Consortium (NARAC).Results:Among 620 patients with 1 or both parents having a HLA genotype, patients with RA informative for analysis included 176 without HLA-DRB1*04 and 86 without the HLA shared epitope (SE). The frequency of NIMA encoding HLA-DR4 or the SE was compared to the non-inherited paternal allele (NIPA). DR4-encoding NIMA vs NIPA revealed no significant difference (27% vs 20%). However, parity is known to modulate RA risk and analyses stratified by sex and age of onset showed significant variation among women. Interestingly, among women with onset <45 years DR4-encoding NIMA was increased compared to NIPA; among women ⩾45 years at onset the reverse was observed (31% vs 16% compared to 10% vs 60%, p = 0.008). DR4 encoding NIMA vs NIPA did not differ in men. The SE did not differ in men or women.Conclusions:Risk of RA was associated with HLA-DR4 encoding NIMA in younger-onset women but not in older-onset women or men. These observations could help explain conflicting prior results of NIMA in RA.

scholarly journals Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis

2015 ◽  
Vol 60 (11) ◽  
pp. 691-696 ◽  
Author(s):  
Hiroshi Furukawa ◽  
Shomi Oka ◽  
Kota Shimada ◽  
Atsushi Hashimoto ◽  
Shigeto Tohma
Keyword(s):  
Rheumatoid Arthritis ◽  
Personalized Medicine ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
And Personalized Medicine

scholarly journals Killer immunoglobulin-like receptor and human leukocyte antigen-C genotypes in rheumatoid arthritis primary responders and non-responders to anti-TNF-α therapy

2011 ◽  
Vol 32 (6) ◽  
pp. 1647-1653 ◽  
Author(s):  
Cathy M. McGeough ◽  
Daniel Berrar ◽  
Gary Wright ◽  
Clare Mathews ◽  
Paula Gilmore ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Tnf Α
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