Faculty Opinions recommendation of Activation of a bacterial virulence protein by the GTPase RhoA.

Author(s):  
Alfred Wittinghofer
2009 ◽  
Vol 2 (95) ◽  
pp. ra71-ra71 ◽  
Author(s):  
M. Christen ◽  
L. H. Coye ◽  
J. S. Hontz ◽  
D. L. LaRock ◽  
R. A. Pfuetzner ◽  
...  

2008 ◽  
Vol 4 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Heather B. Felise ◽  
Hai V. Nguyen ◽  
Richard A. Pfuetzner ◽  
Kathleen C. Barry ◽  
Stona R. Jackson ◽  
...  

2008 ◽  
Vol 105 (40) ◽  
pp. 15429-15434 ◽  
Author(s):  
Benoît Lacroix ◽  
Abraham Loyter ◽  
Vitaly Citovsky

Agrobacteriumrepresents the only natural example of transkingdom transfer of genetic information, from bacteria to plants. Before the bacterial transferred DNA (T- DNA) can integrate into the plant genome, it should be targeted to and bind the host chromatin. However, the T-DNA association with the host chromatin has not been demonstrated. Here, we study T-DNA binding to plant nucleosomesin vitroand show that it is mediated by bacterial and host proteins associated with the T-DNA. The main factor that determines nucleosomal binding of the T-DNA is the cellular VirE2-interacting protein 1 (VIP1), which functions as a molecular link between the T-DNA-associated bacterial virulence protein VirE2 and core histones. The presence of both VIP1 and VirE2 is required for association of the T-DNA with mononucleosomes in which the DNA molecule exists as a tripartite complex DNA–VirE2–VIP1. Furthermore, this nucleosome-associated ternary complex can bind another bacterial virulence factor, VirF, which is an F-box protein known to target both VirE2 and VIP1 for proteasomal degradation and uncoat the T-DNA.


Cell ◽  
2013 ◽  
Vol 154 (1) ◽  
pp. 146-156 ◽  
Author(s):  
Eun-Jin Lee ◽  
Mauricio H. Pontes ◽  
Eduardo A. Groisman

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