Faculty Opinions recommendation of The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs.

2011 ◽  
Author(s):  
Donna Fekete
Keyword(s):  
Hair Cells ◽  
Supporting Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells ◽  
E Cadherin

scholarly journals Chicken Auditory Supporting Cells Express Interferon Response Genes during Regeneration towards Nascent Sensory Hair Cells In Vivo

2021 ◽  
Author(s):  
Amanda S Janesick ◽  
Mirko Scheibinger ◽  
Nesrine Benkafadar ◽  
Sakin Kirti ◽  
Stefan Heller
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Cell Loss ◽  
Basilar Papilla ◽  
Interferon Response ◽  
Hair Cell Loss ◽  
Supporting Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells

The avian hearing organ is the basilar papilla that, in sharp contrast to the mammalian cochlea, can regenerate sensory hair cells and thereby recover from complete deafness within weeks. The mechanisms that trigger, sustain, and terminate the regenerative response in vivo are largely unknown. Here, we profile the changes in gene expression in the chicken basilar papilla after aminoglycoside antibiotic-induced hair cell loss using RNA-sequencing. The most prominent changes in gene expression were linked to the upregulation of interferon response genes which occurred in supporting cells, confirmed by single-cell RNA-sequencing and in situ hybridization. We determined that the JAK/STAT signaling pathway is essential for the interferon gene response in supporting cells, set in motion by hair cell loss. Four days after ototoxic damage, we identified newly regenerated, nascent auditory hair cells that express genes linked to termination of the interferon response. These cells are incipient modified neurons that represent a population of hair cells en route towards obtaining their location-specific and fully functional cell identity. The robust, transient expression of immune-related genes in supporting cells suggests a potential functional involvement of JAK/STAT signaling and interferon in sensory hair cell regeneration.

Regeneration of sensory hair cells after acoustic trauma

Science ◽  
1988 ◽  
Vol 240 (4860) ◽  
pp. 1772-1774 ◽  
Author(s):  
JT Corwin ◽  
DA Cotanche
Keyword(s):  
Hearing Loss ◽  
Hair Cells ◽  
Acoustic Trauma ◽  
Sensory Cells ◽  
Lesion Site ◽  
Supporting Cells ◽  
Profound Hearing Loss ◽  
Cochlear Hair Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells

Any loss of cochlear hair cells has been presumed to result in a permanent hearing deficit because the production of these cells normally ceases before birth. However, after acoustic trauma, injured sensory cells in the mature cochlea of the chicken are replaced. New cells appear to be produced by mitosis of supporting cells that survive at the lesion site and do not divide in the absence of trauma. This trauma-induced division of normally postmitotic cells may lead to recovery from profound hearing loss.

scholarly journals Supporting Cells Eliminate Dying Sensory Hair Cells to Maintain Epithelial Integrity in the Avian Inner Ear

2010 ◽  
Vol 30 (37) ◽  
pp. 12545-12556 ◽  
Author(s):  
J. E. Bird ◽  
N. Daudet ◽  
M. E. Warchol ◽  
J. E. Gale
Keyword(s):  
Inner Ear ◽  
Hair Cells ◽  
Supporting Cells ◽  
Epithelial Integrity ◽  
Sensory Hair ◽  
Sensory Hair Cells ◽  
Avian Inner Ear

scholarly journals Synaptically silent sensory hair cells in zebrafish are recruited after damage

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Qiuxiang Zhang ◽  
Suna Li ◽  
Hiu-Tung C. Wong ◽  
Xinyi J. He ◽  
Alisha Beirl ◽  
...  
Keyword(s):  
Hair Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells

Molecular anatomy and physiology of exocytosis in sensory hair cells

Cell Calcium ◽  
2012 ◽  
Vol 52 (3-4) ◽  
pp. 327-337 ◽  
Author(s):  
Mark A. Rutherford ◽  
Tina Pangršič
Keyword(s):  
Hair Cells ◽  
Sensory Hair ◽  
Anatomy And Physiology ◽  
Sensory Hair Cells ◽  
Molecular Anatomy

S-100 protein is a selective marker for sensory hair cells of the lateral line system in teleosts

2002 ◽  
Vol 329 (2) ◽  
pp. 133-136 ◽  
Author(s):  
F Abbate ◽  
S Catania ◽  
A Germanà ◽  
T González ◽  
B Diaz-Esnal ◽  
...  
Keyword(s):  
Lateral Line ◽  
Hair Cells ◽  
Lateral Line System ◽  
Selective Marker ◽  
Line System ◽  
Sensory Hair ◽  
Sensory Hair Cells ◽  
S 100

scholarly journals The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ruishuang Geng ◽  
David N Furness ◽  
Chithra K Muraleedharan ◽  
Jinsheng Zhang ◽  
Alain Dabdoub ◽  
...  
Keyword(s):  
Hair Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells ◽  
And Function

scholarly journals The Effects of Pro-inflammatory Cytokines by Cisplatin on the Death of Sensory Hair Cells.

2008 ◽  
Vol 18 (4) ◽  
pp. 542-549
Author(s):  
Jeong-Han Lee ◽  
Chan-Ny Park ◽  
Rae-Kil Park
Keyword(s):  
Inflammatory Cytokines ◽  
Hair Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells ◽  
Pro Inflammatory Cytokines

scholarly journals Mutations in ap1b1 Cause Mistargeting of the Na+/K+-ATPase Pump in Sensory Hair Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60866 ◽  
Author(s):  
Rachel Clemens Grisham ◽  
Katie Kindt ◽  
Karin Finger-Baier ◽  
Bettina Schmid ◽  
Teresa Nicolson
Keyword(s):  
Hair Cells ◽  
Sensory Hair ◽  
Sensory Hair Cells
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