Faculty Opinions recommendation of Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study.

2012 ◽  
Author(s):  
Henry Burger
Keyword(s):  
Weight Gain ◽  
Controlled Study ◽  
First Episode ◽  
Double Blind ◽  
First Episode Schizophrenia

Olanzapine-Induced Weight Gain in Patients With First-Episode Schizophrenia: A Double-Blind, Placebo-Controlled Study of Fluoxetine Addition

2002 ◽  
Vol 159 (6) ◽  
pp. 1058-1060 ◽  
Author(s):  
Michael Poyurovsky ◽  
Artashes Pashinian ◽  
Irit Gil-Ad ◽  
Rachel Maayan ◽  
Michael Schneidman ◽  
...  
Keyword(s):  
Weight Gain ◽  
Controlled Study ◽  
First Episode ◽  
Double Blind ◽  
Double Blind Placebo ◽  
First Episode Schizophrenia

Melatonin for prevention of metabolic side-effects of olanzapine in patients with first-episode schizophrenia: Randomized double-blind placebo-controlled study

2014 ◽  
Vol 53 ◽  
pp. 133-140 ◽  
Author(s):  
Amirhossein Modabbernia ◽  
Parvaneh Heidari ◽  
Robabeh Soleimani ◽  
Abdolrasoul Sobhani ◽  
Zahra Atrkar Roshan ◽  
...  
Keyword(s):  
Side Effects ◽  
Controlled Study ◽  
First Episode ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Metabolic Side Effects ◽  
First Episode Schizophrenia

A Pilot Double-Blind, Dose-Comparison Study of Risperidone in Drug-Naive, First-Episode Schizophrenia

2001 ◽  
Vol 62 (12) ◽  
pp. 994-995 ◽  
Author(s):  
Hsien-Yuan Lane ◽  
Wen-Ho Chang ◽  
Chih-Chiang Chiu ◽  
Ming-Chyi Huang ◽  
Sue-Hong Lee ◽  
...  
Keyword(s):  
First Episode ◽  
Comparison Study ◽  
Double Blind ◽  
Dose Comparison ◽  
Drug Naïve ◽  
First Episode Schizophrenia

scholarly journals S201. HIPPOCAMPAL SUBFIELD VOLUMES AND CHANGE IN BODY MASS OVER 12 MONTHS OF TREATMENT IN FIRST-EPISODE SCHIZOPHRENIA SPECTRUM DISORDERS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S114-S115
Author(s):  
Stéfan Du Plessis ◽  
Hilmar Luckhoff ◽  
Sanja Kilian ◽  
Laila Asmal ◽  
Frederika Scheffler ◽  
...  
Keyword(s):  
Substance Use ◽  
Weight Gain ◽  
Body Mass ◽  
Interactive Effect ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Hippocampal Subfields ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia

Abstract Background In this study, we explored the relationship between hippocampal subfield volumes and change in body mass over 12 months of treatment in 90 first-episode schizophrenia spectrum disorder patients (66 males, 24 females; mean age= 24.7±6.8 years). Methods Body mass index was assessed in patients at baseline, and at months 3, 6, 9 and 12. Hippocampal subfields of interest were assessed using a segmentation algorithm included in the FreeSurfer 6.0 software program. Results Linear regression analysis showed a significant interactive effect between sex and anterior hippocampus size as a predictor of change in body mass over 12 months, adjusting for age, substance use, treatment duration, and posterior hippocampal volumes. In an exploratory sub-analysis, partial correlations revealed a significant association between weight gain and smaller CA1, CA3 and subiculum volumes in females, but not males, adjusting for age and substance use, with similar trends evident for the CA4 and presubiculum subfields. Discussion In conclusion, our findings suggest that smaller anterior hippocampal subfields are associated with the development of weight gain over the course of treatment in first-episode schizophrenia spectrum disorders in a sex-specific fashion, and may partly explain the more severe and ongoing increase in body mass evident for female patients.

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