Faculty Opinions recommendation of Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation.

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

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Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity

Proteomes ◽

10.3390/proteomes6040040 ◽

2018 ◽

Vol 6 (4) ◽

pp. 40 ◽

Cited By ~ 5

Author(s):

Joongkyu Park

Keyword(s):

Synaptic Plasticity ◽

Drug Addiction ◽

Ampa Receptor ◽

Long Term Potentiation ◽

Synaptic Activity ◽

Regulatory Proteins ◽

Cellular Models ◽

Brain Functions ◽

Term Potentiation

Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity.

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A Juvenile form of Postsynaptic Hippocampal Long‐Term Potentiation in Mice Deficient for the AMPA Receptor Subunit GluR‐A

The Journal of Physiology ◽

10.1113/jphysiol.2003.053637 ◽

2003 ◽

Vol 553 (3) ◽

pp. 843-856 ◽

Cited By ~ 88

Author(s):

Vidar Jensen ◽

Katharina M. M. Kaiser ◽

Thilo Borchardt ◽

Giselind Adelmann ◽

Andrei Rozov ◽

...

Keyword(s):

Ampa Receptor ◽

Long Term Potentiation ◽

Receptor Subunit ◽

Juvenile Form ◽

Term Potentiation ◽

Ampa Receptor Subunit

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Coupled feedback loops maintain synaptic long-term potentiation: A computational model of PKMzeta synthesis and AMPA receptor trafficking

PLoS Computational Biology ◽

10.1371/journal.pcbi.1006147 ◽

2018 ◽

Vol 14 (5) ◽

pp. e1006147 ◽

Cited By ~ 10

Author(s):

Peter Helfer ◽

Thomas R. Shultz

Keyword(s):

Computational Model ◽

Ampa Receptor ◽

Long Term Potentiation ◽

Feedback Loops ◽

Receptor Trafficking ◽

Term Potentiation ◽

Ampa Receptor Trafficking

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GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2002.1215 ◽

2003 ◽

Vol 358 (1432) ◽

pp. 715-720 ◽

Cited By ~ 17

Author(s):

Fabrice Duprat ◽

Michael Daw ◽

Wonil Lim ◽

Graham Collingridge ◽

John Isaac

Keyword(s):

Synaptic Plasticity ◽

Ampa Receptor ◽

Protein Interactions ◽

Ampa Receptors ◽

Long Term Potentiation ◽

Synaptic Proteins ◽

Mammalian Brain ◽

Protein Protein Interactions ◽

Term Potentiation

AMPA-type glutamate receptors mediate most fast excitatory synaptic transmissions in the mammalian brain. They are critically involved in the expression of long-term potentiation and long-term depression, forms of synaptic plasticity that are thought to underlie learning and memory. A number of synaptic proteins have been identified that interact with the intracellular C-termini of AMPA receptor subunits. Here, we review recent studies and present new experimental data on the roles of these interacting proteins in regulating the AMPA receptor function during basal synaptic transmission and plasticity.

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