Faculty of 1000 evaluation for Taxane-cisplatin-fluorouracil as induction chemotherapy in locally advanced head and neck cancers: an individual patient data meta-analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group.

2013 ◽  
Author(s):  
Bruce Brockstein ◽  
Nicholas Campbell
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Head And Neck Cancers ◽  
Advanced Head ◽  
Cancer Group

scholarly journals Combination of Taxanes, Cisplatin and Fluorouracil as Induction Chemotherapy for Locally Advanced Head and Neck Cancer: A Meta-Analysis

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51526 ◽  
Author(s):  
Hao Qin ◽  
Jie Luo ◽  
Yuan-Ping Zhu ◽  
Hai-Li Xie ◽  
Wei-Qiang Yang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Advanced Head

Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers: An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group

2013 ◽  
Vol 31 (23) ◽  
pp. 2854-2860 ◽  
Author(s):  
Pierre Blanchard ◽  
Jean Bourhis ◽  
Benjamin Lacas ◽  
Marshall R. Posner ◽  
Jan B. Vermorken ◽  
...  
Keyword(s):  
Head And Neck ◽  
Induction Chemotherapy ◽  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Patient Data ◽  
Head And Neck Cancers ◽  
Rank Test ◽  
Advanced Head

Purpose Cisplatin plus fluorouracil (PF) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) in randomized trials in locoregionally advanced head and neck cancers (LAHNCs). The aim of this meta-analysis was to study the efficacy and toxicity of Tax-PF and PF and identify differences in outcomes in subsets of patients. Methods Five randomized trials representing 1,772 patients were identified. Updated individual patient data (IPD) were retrieved for all trials. The log-rank test, stratified by trial, was used for comparison. Interaction or trend tests were used to study the interaction between covariates and treatment. Results Median follow-up was 4.9 years. The hazard ratio (HR) of death was 0.79 (95% CI, 0.70 to 0.89; P < .001; absolute benefit at 5 years: 7.4%) in favor of Tax-PF. Heterogeneity was significant (P = .08, I2 = 51%) and related to one trial. There was no more heterogeneity after exclusion of this trial (P = .99, I2 = 0%), and HR of death was 0.72 (95% CI, 0.63 to 0.83) in favor of Tax-PF. There was no interaction between treatment effect and the following patient covariates: age, sex, performance status, tumor stage, or site. Tax-PF was associated with significant reductions of progression, locoregional failure, and distant failure compared with PF, with HRs of 0.78 (95% CI, 0.69 to 0.87; P < .001), 0.79 (95% CI, 0.66 to 0.94; P = .007), and 0.63 (95% CI, 0.45 to 0.89; P = .009) respectively. Conclusion This IPD meta-analysis shows the superiority of Tax-PF over PF as induction chemotherapy. Its precise role in the management of LAHNC remains to be determined.

scholarly journals Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis

2021 ◽  
Author(s):  
Claire Petit ◽  
Benjamin Lacas ◽  
Jean-Pierre Pignon ◽  
Quynh Thu Le ◽  
Vincent Grégoire ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Locally Advanced ◽  
Patient Data ◽  
Advanced Head ◽  
Data Network

Induction Chemotherapy in Locally Advanced Head and Neck Cancer: A New Standard of Care?

2008 ◽  
Vol 22 (6) ◽  
pp. 1155-1163 ◽  
Author(s):  
Jochen H. Lorch ◽  
Marshall R. Posner ◽  
Lori J. Wirth ◽  
Robert I. Haddad
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Advanced Head

Comparison of carboplatin–paclitaxel to docetaxel–cisplatin-5–flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and neck cancer

Oral Oncology ◽  
2014 ◽  
Vol 50 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Lauren C. Herman ◽  
Lucy Chen ◽  
Alexandra Garnett ◽  
Lawrence E. Feldman ◽  
Brett Smith ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Concurrent Chemoradiation ◽  
Advanced Head

PRELIMINARY RESULTS OF INDUCTION CHEMOTHERAPY WITH TPF IN LOCALLY ADVANCED HEAD AND NECK CANCER IN ASSOCIATION WITH HPV STATUS

2011 ◽  
Vol 98 ◽  
pp. S41
Author(s):  
D. Xesfyngi ◽  
G. loannidou ◽  
M. Plochorou ◽  
E. Stavrinidis ◽  
K. Papaia ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head ◽  
Preliminary Results ◽  
Hpv Status

scholarly journals Postoperative Radiotherapy in Head and Neck Cancer

2010 ◽  
Vol 2 (1) ◽  
pp. 43-51
Author(s):  
Vedang Murthy ◽  
Sayan Kundu ◽  
Tanweer Shahid ◽  
Ashwini Budrukkar ◽  
Tejpal Gupta ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Targeted Therapy ◽  
Head And Neck ◽  
Neck Cancer ◽  
Early Stage ◽  
Postoperative Radiotherapy ◽  
Locally Advanced ◽  
Head And Neck Cancers ◽  
Advanced Head ◽  
Locoregional Failure

Abstract Though early stage head and neck cancers can be cured either by surgery or radiation, patients with locally advanced disease continues to pose a therapeutic challenge. Locoregional failure is the major cause of death in head and neck cancers. As the outcome of locally advanced head and neck cancer is less than promising, a combined modality approach is generally undertaken in this group of patients. The combination of surgery, radiation and more recently, chemotherapy and targeted therapy can improve outcomes in locally advanced head and neck cancer patients. This overview discusses the rationale and role of postoperative radiotherapy (PORT) in advanced head and neck cancers, the radiotherapy technique in brief and methods of enhancing the efficacy of postoperative RT by altering the fractionation schedules and adding chemotherapy and targeted therapy.

scholarly journals Induction Chemotherapy with Docetaxel, Cisplatin and Fluorouracil (Tpf) in Locally Advanced Head and Neck Cancer–Single Center Retrospective Analysis

2014 ◽  
Vol 25 ◽  
pp. iv348
Author(s):  
M. Cassiano Neves ◽  
A. Rosinha ◽  
J. Magalhaes ◽  
A.F.M.F. Castro ◽  
C.M.P. Vieira ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Retrospective Analysis ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head ◽  
Single Center
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