Faculty Opinions recommendation of Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects.

2015 ◽  
Author(s):  
Di Chen
Keyword(s):  
Potential Role ◽  
Kinase Inhibitors ◽  
Differential Regulation ◽  
P38 Kinase ◽  
Human Chondrosarcoma

scholarly journals Potential role of tyrosine kinase inhibitors during primary HIV-1 infection

2017 ◽  
Vol 15 (5) ◽  
pp. 421-423 ◽  
Author(s):  
Juan Ambrosioni ◽  
Mayte Coiras ◽  
José Alcamí ◽  
José M. Miró
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Potential Role ◽  
Kinase Inhibitors ◽  
Hiv 1

scholarly journals Reply: Potential role of Janus kinase inhibitors in COVID-19

2020 ◽  
Vol 83 (1) ◽  
pp. e65 ◽  
Author(s):  
Maddalena Napolitano ◽  
Gabriella Fabbrocini ◽  
Cataldo Patruno
Keyword(s):  
Potential Role ◽  
Kinase Inhibitors ◽  
Janus Kinase ◽  
Janus Kinase Inhibitors

Therapeutic challenges of kinase and phosphatase inhibition and use in anti-diabetic strategy

2005 ◽  
Vol 33 (2) ◽  
pp. 343-345 ◽  
Author(s):  
A.J. Bridges
Keyword(s):  
Potential Role ◽  
Hormone Receptors ◽  
Kinase Inhibitors ◽  
Glycogen Synthesis ◽  
Disease Process ◽  
Biological Processes ◽  
Insulin Receptor Tyrosine Kinase ◽  
Phosphatase Inhibitors ◽  
Early Results

The development of kinase and phosphatase inhibitors as novel therapeutic agents has been stimulated by the discovery that most biological processes are controlled by the reversible phosphorylation of proteins. Most of the early results in this area were generated in oncology, at the same time as the human genome, with its 500+ kinases and 100+ phosphatases was deciphered. Because of this, we know a great deal about which processes signalling inhibitors interfere with, but little about the overall consequences. In this study, kinases will be briefly reviewed, followed by some of the early problems in developing kinase inhibitors, as biochemical reagents, and clinically active pharmaceuticals in oncology. The discussion will then switch to the potential role of kinases and phosphatases in controlling the disease process in Type II diabetes. Phosphatase inhibitors should augment insulin receptor tyrosine kinase signalling. Glycogen synthesis and glycogenolysis are phosphorylation dependent, and amenable to kinase inhibition, as are some nuclear hormone receptors, and these will be briefly discussed.

scholarly journals HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19

2020 ◽  
Vol 5 (47) ◽  
pp. eabc5367 ◽  
Author(s):  
Francesca Romana Spinelli ◽  
Fabrizio Conti ◽  
Massimo Gadina
Keyword(s):  
Potential Role ◽  
Kinase Inhibitors ◽  
Cytokine Storm ◽  
Jak Inhibitors ◽  
Jak Kinase

JAK kinase inhibitors are being investigated as a way of managing cytokine storm in severe COVID-19 patients.

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