Faculty Opinions recommendation of Complete remission of severe hidradenitis suppurativa obtained in 4 patients using wide-spectrum antimicrobial treatment.

Sexually transmitted infections (STIs) are caused by a wide spectrum of bacteria, viruses and parasites. These agents can be easily transmitted during any direct genital or oral sexual contact. Recently, World Health Organization (WHO), reported that more than 1 million STIs are acquired every day worldwide, Each year, there are an estimated 357 million new infections with 1 of 4 STIs: chlamydia, gonorrhoea, syphilis and trichomoniasis. There are few studies and official reports published on the prevalence of STIs in most Arab countries. However, few new recent studies showed increased prevalence of certain STIs in some Arab countries.

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Seroprevalence of Antibodies against Tick-Borne Pathogens in Czech Patients with Suspected Post-Treatment Lyme Disease Syndrome

Microorganisms ◽

10.3390/microorganisms9112217 ◽

2021 ◽

Vol 9 (11) ◽

pp. 2217

Author(s):

Kristyna Sloupenska ◽

Jana Dolezilkova ◽

Barbora Koubkova ◽

Beata Hutyrova ◽

Mojmir Racansky ◽

...

Keyword(s):

Lyme Disease ◽

Significant Influence ◽

Anaplasma Phagocytophilum ◽

Wide Spectrum ◽

Bartonella Henselae ◽

Antimicrobial Treatment ◽

Post Treatment ◽

Babesia Microti ◽

Serum Samples ◽

Good Agreement

The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from 103 patients with suspected post-treatment Lyme disease syndrome were tested for the presence of antibodies to the major tick-borne pathogens Anaplasma phagocytophilum, Bartonella henselae/Bartonella quinatana, and Babesia microti. Although the presence of anti-Anaplasma antibodies was detected in 12.6% of the samples and anti-Bartonella antibodies in 9.7% of the samples, the presence of antibodies against both pathogens in the same samples or anti-Babesia antibodies in the selected group of patients could not be confirmed. However, we were able to detect autoantibodies, mostly antinuclear, in 11.6% of the patients studied. Our results are in good agreement with previously published studies showing the presence of a wide spectrum of autoantibodies in some patients with complicated forms of Lyme disease and post-treatment Lyme disease syndrome, but they do not reveal a significant influence of co-infections on the development of PTLDS in the studied group of patients.

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Hidradenitis suppurativa after renal transplantation: Complete remission after switching from oral cyclosporine to oral tacrolimus

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2014.06.031 ◽

2014 ◽

Vol 71 (5) ◽

pp. e210-e211 ◽

Cited By ~ 9

Author(s):

Emilie Ducroux ◽

Maria Andrea Ocampo ◽

Jean Kanitakis ◽

Emmanuel Morelon ◽

Denis Jullien ◽

...

Keyword(s):

Renal Transplantation ◽

Complete Remission ◽

Hidradenitis Suppurativa

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2622. Multiplex Polymerase Chain Reaction (PCR) Panels in Pediatric Hospital Care: New Insights into Factors Driving Antimicrobial Use

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.2300 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S913-S914 ◽

Cited By ~ 1

Author(s):

Claudia L Gaviria Agudelo ◽

Milza Howard ◽

Mary M Barr ◽

Melissa West ◽

Philip L Whitfield ◽

...

Keyword(s):

Antimicrobial Therapy ◽

Hospital Care ◽

Wide Spectrum ◽

Antimicrobial Treatment ◽

Pediatric Care ◽

Diagnostic Tools ◽

Antimicrobial Use ◽

Pediatric Hospital ◽

Icu Admission ◽

Syncytial Virus

Abstract Background Multiplex PCR panels are diagnostic tools that first became available in 2011. They have rapid turnaround time and excellent sensitivity and specificity for a wide spectrum of microbial targets. However, it remains controversial whether its widespread use leads to optimal use of antimicrobials. We aimed to determine whether use of these tests was associated with appropriate antimicrobial therapy (AAT). Methods We conducted a single-center, retrospective study of hospitalized pediatric patients from 2015 to 2018 looking at 4 different respiratory panels and 1 meningoencephalitis panel (MEP). We analyzed test results and compared them to antimicrobial treatment. Using logistic regression, we analyzed the clinical and laboratory factors associated with AAT (defined as directed antimicrobial therapy based on clinical assessment and tests results). Results There were 1,002 encounters in 951 patients. Mean length of stay was 7 days. 53.2% encounters had intensive care unit (ICU) admission. 77.1% of respiratory panels and 17.3% of MEP were positive. Co-detection in respiratory samples was 44.2%. Enterovirus was the most common virus detected while H. influenza was the most frequent bacteria. Respiratory Syncytial Virus was commonly detected with bacteria when compared with other common viruses. 13.4% patients were intubated, concordance with sputum culture was 63%. Patients admitted to the floor were more likely to have AAT than ICU patients (82.5% vs. 71.7%). ICU admission increased the odds of unnecessary antimicrobials (OR 1.6; 95% CI 1.1–2.5). Positive result from a comprehensive respiratory panel (bacteria + virus) decreased the odds of AAT (odds ratio: 0.4, 95% CI 0.3–0.8). Age, season, comorbidity, and intubation were not significantly associated with AAT. Only 0.5% of blood cultures in patients tested for respiratory infection were positive (3/579). Conclusion We present new insights into factors driving antimicrobial use in pediatric hospital care. ICU admission was significantly associated with unnecessary antimicrobial use after adjusting for clinical findings and diagnostics. Frequently PCR results were not acted upon or caused additional use of antimicrobials. Further investigation is warranted to understand factors influencing antimicrobial use in pediatric care. Disclosures All authors: No reported disclosures.

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