Faculty Opinions recommendation of Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells.

Author(s):  
Jonathan Kaunitz
2014 ◽  
Vol 29 (4) ◽  
pp. 1395-1403 ◽  
Author(s):  
Christopher S. Reigstad ◽  
Charles E. Salmonson ◽  
John F. Rainey III ◽  
Joseph H. Szurszewski ◽  
David R. Linden ◽  
...  

1987 ◽  
Vol 58 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Takashi Sakata

1. Effects of short-chain fatty acids (SCFA) on epithelial proliferation of the intestine were studied in ileally fistulated rats fed on an elemental diet.2. The stimulatory effect of daily doses of acetic, propionic and n-butyric acids (100,20 and 60 mM respectively; pH 6.1) per fistula (3 ml, twice daily) on crypt cell production rate (CCPR) appeared within 2 d and lasted for at least 5 d.3. The daily doses of SCFA for 14 d increased daily CCPR three to four fold. This effect was independent of the presence of gut bacteria.4. Effects of SCFA were dose-dependent and varied among acids (butyrate > propionate > acetate). The effect was independent of low lumen pH.5. In contrast, SCFA inhibited epithelial proliferation of isolated rat caecal tissue in vitro.6. These results suggest that SCFA are physiological lumen trophic factors mediated by a systemic mechanism in vivo.7. It is concluded that SCFA are involved in the trophic effects of gut microbes, ingestion of fermentable fibre, and lumen contents.


1994 ◽  
Vol 92 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Mercedes Gallardo ◽  
Paloma Munoz De Rueda ◽  
Angel Jesus Matilla ◽  
Isabel Maria Sanchez-Calle

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 92-OR ◽  
Author(s):  
WEI HUANG ◽  
YONG XU ◽  
YOUHUA XU ◽  
LUPING ZHOU ◽  
CHENLIN GAO

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