Faculty Opinions recommendation of Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.

2015 ◽  
Author(s):  
Richard P Dutton
Keyword(s):  
Clinical Trial ◽  
Red Blood Cells ◽  
Randomized Clinical Trial ◽  
Blood Cells ◽  
Severe Trauma

scholarly journals Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

JAMA ◽  
2015 ◽  
Vol 313 (5) ◽  
pp. 471 ◽  
Author(s):  
John B. Holcomb ◽  
Barbara C. Tilley ◽  
Sarah Baraniuk ◽  
Erin E. Fox ◽  
Charles E. Wade ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Severe Trauma

Transfusion of plasma, platelets, and Red Blood Cells in a 1:1:1 versus a 1:1:2 Ration and Mortality in Patients with Severe Trauma

2018 ◽  
pp. 248-254
Author(s):  
Yuk Ming Liu ◽  
Kathryn Butler
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Clinical Case ◽  
Severe Trauma ◽  
Trauma Patients ◽  
Transfusion Ratio ◽  
Study Intervention ◽  
Traumatic Hemorrhage ◽  
Ratio Versus

This chapter provides a summary of the landmark study known as the PROPPR trial. How effective and safe is rapid transfusion of patients with severe traumatic hemorrhage using plasma, platelets, and red blood cells in a 1:1:1 ratio compared to a 1:1:2 ratio? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. A growing body of literature suggests that massive transfusion protocols confer mortality benefits for trauma patients in hemorrhagic shock; however, such protocols still require standardization. In the PROPPR trial, there was suggestion of improved hemostasis and less death from exsanguinations with a 1:1:1 transfusion ratio versus a 1:1:2 approach; however, further trials are warranted.

scholarly journals RELATIONSHIP BETWEEN TRANSFUSION OF PACKED RED BLOOD CELLS, PLASMA FREE HEMOGLOBIN AND STORAGE TIME IN PATIENTS WITH SEVERE TRAUMA

2015 ◽  
Vol 3 (Suppl 1) ◽  
pp. A916
Author(s):  
S Chacón Alves ◽  
M Chico Fernández ◽  
C García Fuentes ◽  
A Del Pino Ramírez ◽  
N Zurera Plaza ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Storage Time ◽  
Severe Trauma ◽  
Free Hemoglobin ◽  
Packed Red Blood Cells ◽  
And Storage
Sign in / Sign up

Export Citation Format

Share Document