scholarly journals RELATIONSHIP BETWEEN TRANSFUSION OF PACKED RED BLOOD CELLS, PLASMA FREE HEMOGLOBIN AND STORAGE TIME IN PATIENTS WITH SEVERE TRAUMA

2015 ◽  
Vol 3 (Suppl 1) ◽  
pp. A916
Author(s):  
S Chacón Alves ◽  
M Chico Fernández ◽  
C García Fuentes ◽  
A Del Pino Ramírez ◽  
N Zurera Plaza ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Storage Time ◽  
Severe Trauma ◽  
Free Hemoglobin ◽  
Packed Red Blood Cells ◽  
And Storage

Erythroplateletapheresis: A New Strategy in the Global Apheresis Program

1998 ◽  
Vol 21 (6_suppl) ◽  
pp. 17-19
Author(s):  
G. Menichella ◽  
M. Ciarli ◽  
R. Serafini ◽  
L. Pierelli ◽  
M. Vittori ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Plasma Volume ◽  
Blood Cells ◽  
Storage Time ◽  
Blood Donation ◽  
Mean Values ◽  
Packed Red Blood Cells ◽  
New Strategy ◽  
The Mean

Blood donation allowed by cell separators can offer higher performance and higher yield to guarantee better quality and pureness of collected products. New systems for the collection of platelet concentrate (PC) and packed red blood cells (PRBC) are currently available. The aim of our work was to test the possibility of preparing PC routinely from normal apheresis donors in a minimum amount of time while providing a second product. Over a 3-month period we performed 40 procedures using the Hemonetics MCS3P blood cell separator and the Dideco Excel. The mean values of platelet yield were 2.8 x 1011 (range 1.4-4.1) with the MCS3P and 3.49 x 1011 (range 2.9-3.9) with the Excel, in a plasma volume of 240 ml and 215 ml respectively; the PRBC units were added with SAG-Mannitol allowing a storage time of 42 days. Collection times were 71’ and 48’ respectively. Donor tolerance was analogous to phateletapheresis or plasmapheresis.

Evaluation of hematologic, biochemical, and blood gas variables in stored canine packed red blood cells, and the impact of storage time on blood recipients

2020 ◽  
Vol 49 (2) ◽  
pp. 198-206
Author(s):  
Renata R. Rodrigues ◽  
Caroline Y. Kayano ◽  
Vinícius P. Santos ◽  
Ludmila R. Moroz ◽  
Denise T. Fantoni ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Storage Time ◽  
Blood Gas ◽  
Packed Red Blood Cells ◽  
The Impact

scholarly journals Hemolysis risk after packed red blood cells transfusion with infusion pumps

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
Ana Maria Miranda Martins Wilson ◽  
Maria Angélica Sorgini Peterlini ◽  
Mavilde da Luz Gonçalves Pedreira
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Infusion Pump ◽  
Randomized Study ◽  
Transfusion Practice ◽  
Free Hemoglobin ◽  
Infusion Pumps ◽  
Packed Red Blood Cells ◽  
Total Hemoglobin ◽  
Before And After

ABSTRACT Objective: To evaluate the hemolysis biomarkers of packed red blood cells transfused by two different linear peristaltic infusion pumps at two infusion rates. Method: An experimental and randomized study was designed simulating the clinical practice of transfusion. Two linear peristaltic infusion pumps from different manufactures were studied in triplicate at 100 mL/h and 300mL/h infusion rates. The chosen hemolysis biomarkers were total hemoglobin, free hemoglobin, hematocrit, potassium and degree of hemolysis. They were analyzed before and after each infusion. Results: Potassium showed statistically significant variations in all scenarios of the experiment (P<0.010). In a separated analysis, potassium increased mainly at 300mL/h rate (P=0.021) and free hemoglobin had significant variation when comparing infusion pumps from different manufacturers (P=0.026). Although hematocrit, total hemoglobin and degree of hemolysis had increased after infusion, no statistically significance variations were identified. Conclusions: Hemolysis risk induced by a linear peristaltic infusion pump was identified by an increase in free hemoglobin and potassium markers. As the potassium biomarker is often increased in aged packed red blood cells, we do not recommend using them in this scenario. Additional studies should be performed about other markers and using larger samples in order to reinforce the transfusion practice in nursing.

scholarly journals Immunosuppressive effects of red blood cells on monocytes are related to both storage time and storage solution

Transfusion ◽  
2011 ◽  
Vol 52 (4) ◽  
pp. 794-802 ◽  
Author(s):  
Jennifer Muszynski ◽  
Jyotsna Nateri ◽  
Kathleen Nicol ◽  
Kristin Greathouse ◽  
Lisa Hanson ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Storage Time ◽  
And Storage ◽  
Storage Solution

scholarly journals Time Dependent Assessment of Morphological Changes: Leukodepleted Packed Red Blood Cells Stored in SAGM

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ibrahim Mustafa ◽  
Asma Al Marwani ◽  
Khuloud Mamdouh Nasr ◽  
Noora Abdulla Kano ◽  
Tameem Hadwan
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Storage Time ◽  
Morphological Changes ◽  
Storage Period ◽  
Osmotic Fragility ◽  
Prolonged Storage ◽  
Morphological Alterations ◽  
Packed Red Blood Cells ◽  
Stored Blood

Usually packed red blood cells (pRBCs) require specific conditions in storage procedures to ensure the maximum shelf life of up to 42 days in 2–6°C. However, molecular and biochemical consequences can affect the stored blood cells; these changes are collectively labeled as storage lesions. In this study, the effect of prolonged storage was assessed through investigating morphological changes and evaluating oxidative stress. Samples from leukodepleted pRBC in SAGM stored at 4°C for 42 days were withdrawn aseptically on day 0, day 14, day 28, and day 42. Morphological changes were observed using scanning electron microscopy and correlated with osmotic fragility and hematocrit. Oxidative injury was studied through assessing MDA level as a marker for lipid peroxidation. Osmotic fragility test showed that extended storage time caused increase in the osmotic fragility. The hematocrit increased by 6.6% from day 0 to day 42. The last 2 weeks show alteration in the morphology with the appearance of echinocytes and spherocytes. Storage lesions and morphological alterations appeared to affect RBCs during the storage period. Further studies should be performed to develop strategies that will aid in the improvement of stored pRBC quality and efficacy.

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