Faculty Opinions recommendation of The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.

2015 ◽  
Author(s):  
Hui Hu
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell

scholarly journals The Transcription Factor KLF2 Restrains CD4 + T Follicular Helper Cell Differentiation

Immunity ◽  
2015 ◽  
Vol 42 (2) ◽  
pp. 252-264 ◽  
Author(s):  
June-Yong Lee ◽  
Cara N. Skon ◽  
You Jeong Lee ◽  
Soohwan Oh ◽  
Justin J. Taylor ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell

scholarly journals ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

Immunity ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 932-946 ◽  
Author(s):  
Youn Soo Choi ◽  
Robin Kageyama ◽  
Danelle Eto ◽  
Tania C. Escobar ◽  
Robert J. Johnston ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Effector Cell ◽  
Transcriptional Repressor ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
Cell Versus

scholarly journals Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn’s Disease

2021 ◽  
Vol 11 (1) ◽  
pp. 1-12
Author(s):  
Anna-Maria Globig ◽  
Nikola Patricia Sommer ◽  
Katharina Wild ◽  
Josefine Schardey ◽  
Katharina Zoldan ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Cell Differentiation ◽  
Crohn's Disease ◽  
Helper Cell ◽  
Follicular Helper ◽  
T Follicular Helper Cell

scholarly journals The Transcription Factor Twist1 Limits T Helper 17 and T Follicular Helper Cell Development by Repressing the Gene Encoding the Interleukin-6 Receptor α Chain

2013 ◽  
Vol 288 (38) ◽  
pp. 27423-27433 ◽  
Author(s):  
Duy Pham ◽  
Crystal C. Walline ◽  
Kristin Hollister ◽  
Alexander L. Dent ◽  
Janice S. Blum ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Critical Role ◽  
Cell Development ◽  
Receptor Expression ◽  
Helper Cell ◽  
T Helper 17 ◽  
Gene Encoding ◽  
Extracellular Milieu ◽  
Follicular Helper ◽  
T Follicular Helper Cell

Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu. Transcription factor-mediated regulation of cytokine receptor expression is a common mode of altering responses to the external environment. We identify the transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls IL-6 signals by directly repressing Il6ra. Human and mouse T cells lacking Twist1 have an increased ability to differentiate into Th17 cells. Mice with a T cell-specific deletion of Twist1 demonstrate increased Th17 and T follicular helper cell development, early onset experimental autoimmune encephalomyelitis, and increased antigen-specific antibody responses. Thus, Twist1 has a critical role in limiting both cell-mediated and humoral immunity.

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