Faculty Opinions recommendation of Delivering tailored surgery to older cancer patients: Preoperative geriatric assessment domains and screening tools - A systematic review of systematic reviews.

Author(s):  
Martine Extermann
2013 ◽  
Vol 4 ◽  
pp. S73-S74
Author(s):  
H. Wildiers ◽  
P. Heeren ◽  
A. Artz ◽  
R. Audisio ◽  
R. Bernabei ◽  
...  

2005 ◽  
Vol 55 (3) ◽  
pp. 241-252 ◽  
Author(s):  
Martine Extermann ◽  
Matti Aapro ◽  
Roberto Bernabei ◽  
Harvey Jay Cohen ◽  
Jean-Pierre Droz ◽  
...  

2009 ◽  
Vol 45 (1) ◽  
pp. 19-32 ◽  
Author(s):  
Deborah Fitzsimmons ◽  
Jacqueline Gilbert ◽  
Frances Howse ◽  
Teresa Young ◽  
Juan-Ignacio Arrarras ◽  
...  

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18140-e18140 ◽  
Author(s):  
Beatrice Jara-Almonte Edwards ◽  
Xiaotao Zhang ◽  
Ming Sun ◽  
Juhee Song ◽  
Colin P.N. Dinney ◽  
...  

e18140 Background: More than 60% of cancer patients are older adults, and by 2020 the proportion of older adults with cancer will rise to 70%. Objective: To assess risk factors for overall survival (OS) in older cancer patients seen in a comprehensive cancer center. Methods: This is a single center, retrospective cohort study of older cancer patients (65 years of age and older). Patients receiving active cancer care underwent comprehensive geriatric assessment (including cognitive, mood, functional, nutritional, physical, and comorbidity assessment using validated scales). Hematologic, and solid tumors (urologic, breast, gastrointestinal cancers) were evaluated. Targeted interventions were implemented. Analysis: Univariate and multivariable Cox proportional hazards regression analysis were performed to identify factors associated with OS (SAS 9.4). Results: Among 304 eligible patients, the median follow-up was 12.7 months, 98 (32%) died, the median OS was 25.4 months. Median age is 78 years. Univariate analysis revealed known risk factors for mortality (advanced age [p = 0.004], and metastatic disease [p = 0.002]), functional impairment (ADL scores 0-4, p = 0.02), and major depression (p = 0.005). Comorbidity (p = 0.07) and functional impairment showed a marginal significance on OS. Factors with a univariate p-value less than 0.1 were considered in multivariable regression models. A final multivariable model included age group, cancer stage, functional impairment, and major depression. Risk factors for OS include major depression (HR 1.88 (95% CI, 1.12, 3.15), p-value = 0.02), functional impairment (HR 2.47 (95% C.I. 1.28, 4.74), p = 0.007), and metastatic disease (HR 2.2 (95% C.I. 1.30, 3.97), p = 0.004). Conclusions: Major depression and functional impairment were identified as risk factors for OS in older cancer patients. Prospective studies are recommended.


2007 ◽  
Vol 25 (14) ◽  
pp. 1936-1944 ◽  
Author(s):  
Miriam B. Rodin ◽  
Supriya G. Mohile

More than half of new cancers are diagnosed in elderly patients, but data from randomized clinical trials do not represent the elderly population. Comprehensive geriatric assessment (CGA) can contribute valuable information to oncologists for risk stratification of elderly cancer patients. Functional impairments, frailty markers, cognitive impairments, and physical disabilities increase the risk for adverse outcomes during cancer treatment. Evidence is accumulating that selected elderly cancer patients benefit from CGA and geriatric interventions. However, perceived barriers to CGA include time, familiarity, cost, and lack of a well-defined procedure to interpret and apply the information. We present a model for rapid selection of elderly who would benefit from CGA using screening tools such as the Vulnerable Elders-13 Survey. We also define important geriatric functional risk factors, including mobility limitation, frailty, and dementia, and demonstrate how brief screening tests can make use of data realistically available to clinical oncologists to determine a stage of aging. Summary tables and a decision tree demonstrate how these data can be compiled to determine the risk for toxicities and to anticipate ancillary support needs.


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