Faculty Opinions recommendation of Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration.

2017 ◽  
Author(s):  
Q Richard Lu ◽  
Lai Man Natalie Wu
Keyword(s):  
Nerve Regeneration ◽  
Schwann Cells ◽  
Histone Deacetylase

scholarly journals Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Valérie Brügger ◽  
Mert Duman ◽  
Maëlle Bochud ◽  
Emmanuelle Münger ◽  
Manfred Heller ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Schwann Cells ◽  
Histone Deacetylase

scholarly journals Histopathological analysis of gangliosides use in peripheral nerve regeneration after axonotmesis in rats

2008 ◽  
Vol 23 (4) ◽  
pp. 364-371 ◽  
Author(s):  
Camila Maria Beder Ribeiro ◽  
Belmiro Cavalcanti do Egito Vasconcelos ◽  
Joaquim Celestino da Silva Neto ◽  
Valdemiro Amaro da Silva Júnior ◽  
Nancy Gurgel Figueiredo
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Peripheral Nerve Regeneration ◽  
Cell Activity ◽  
Control Group ◽  
Histopathological Analysis ◽  
Male Wistar Rats ◽  
The Right

PURPOSE: To analyze the action of gangliosides in peripheral nerve regeneration in the sciatic nerve of the rat. METHODS: The sample was composed of 96 male Wistar rats. The animals were anaesthetized and, after identification of the anaesthesic plane, an incision was made in the posterior region of the thigh, followed by skin and muscle divulsion. The right sciatic nerve was isolated and compressed for 2 minutes. Continuous suture of the skin was performed. The animals were randomly divided into two groups: the experimental group (EG), which received subcutaneous injection of gangliosides, and the control group (CG), which received saline solution (0.9%) to mimic the effects of drug administration. RESULTS: No differences were observed between the experimental and control groups evaluated on the eighth day of observation. At 15 and 30 days the EG showed an decrease in Schwann cell activity and an apparent improvement in fibre organization; at 60 days, there was a slight presence of Schwann cells in the endoneural space and the fibres were organized, indicating nerve regeneration. At 15 and 30 days, the level of cell reaction in the CG had diminished, but there were many cells with cytoplasm in activity and in mitosis; at 60 days, hyperplastic Schwann cells and mitotic activity were again observed, as well as nerve regeneration, but to a lesser extent than in the EG. CONCLUSION: The administration of exogenous gangliosides seems to improve nerve regeneration.

In Vitro Evaluation of the Growth and Migration of Schwann Cells on Electrospun Silk Fibroin Nanofibers

2011 ◽  
Vol 175-176 ◽  
pp. 220-223 ◽  
Author(s):  
Ai Jun Hu ◽  
Bao Qi Zuo ◽  
Feng Zhang ◽  
Qing Lan ◽  
Huan Xiang Zhang
Keyword(s):  
Tissue Engineering ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Silk Fibroin ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering ◽  
And Migration ◽  
Silk Fibroin Nanofibers

Schwann cells (SCs) are primary structural and functional cells in peripheral nervous system and play a crucial role in peripheral nerve regeneration. Current challenge in peripheral nerve tissue engineering is to produce an implantable scaffold capable of bridging long nerve gaps and assist Scs in directing the growth of regenerating axons in nerve injury recovery. Electrospun silk fibroin nanofibers, fabricated for the cell culture in vitro, can provide such experiment support. Silk fibroin scaffolds (SFS) were fabricated with formic acid (FA), and the average fiber diameter was 305 ± 24 nm. The data from microscopic, immunohistochemical and scanning electron micrograph confirmed that the scaffold was beneficial to the adherence, proliferation and migration of SCs without exerting any significant cytotoxic effects on their phenotype. Thus, providing an experimental foundation accelerated the formation of bands of Bünger to enhance nerve regeneration. 305 nm SFS could be a candidate material for nerve tissue engineering.

Behavior of axons, Schwann cells and perineurial cells in nerve regeneration within transplanted nerve grafts: effects of anti-laminin and anti-fibronectin antisera

1992 ◽  
Vol 583 (1-2) ◽  
pp. 216-226 ◽  
Author(s):  
Guo-Ying Wang ◽  
Kei-Ichi Hirai ◽  
Hiroki Shimada ◽  
Shiro Taji ◽  
Shi-Zhen Zhong
Keyword(s):  
Nerve Regeneration ◽  
Schwann Cells ◽  
Nerve Grafts ◽  
Perineurial Cells

The Astrocyte Inhibition of Peripheral Nerve Regeneration Is Reversed by Schwann Cells

1994 ◽  
Vol 126 (1) ◽  
pp. 44-60 ◽  
Author(s):  
Véronique Guénard ◽  
Patrick Aebischer ◽  
Richard P. Bunge
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Peripheral Nerve Regeneration

scholarly journals ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2/AMPK pathway

2020 ◽  
Vol 34 (10) ◽  
pp. 13993-14005 ◽  
Author(s):  
Wenzheng Xia ◽  
Jin Zhu ◽  
Xueyi Wang ◽  
Yinda Tang ◽  
Ping Zhou ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Schwann Cells ◽  
Ampk Pathway ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Salidroside promotes sciatic nerve regeneration following combined application epimysium conduit and Schwann cells in rats

2020 ◽  
Vol 245 (6) ◽  
pp. 522-531
Author(s):  
Jiaqi Li ◽  
Yongguang Zhang ◽  
Zhimin Yang ◽  
Jingxian Zhang ◽  
Ren Lin ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Western Blot ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Motor Function ◽  
Nerve Conduit ◽  
Combined Application ◽  
Post Operation ◽  
Sciatic Nerve Regeneration

Schwann cell and nerve conduit are crucial for nerve regeneration and re-myelination after peripheral nerves injury. To investigate the effects of Salidroside on autogenous epimysium conduit mixed with BD matrigel and RSC96 Schwann cells on an animal model with 5 mm sciatic nerve defect injury in rat, motor function, muscle reinnervation, immunohistochemical staining, retrograded tracing and Western blot were used in this study. The results showed that Salidroside enhanced the compound effects of epimysium conduit mixed with BD matrigel and RSC96 Schwann cells to improve the sciatic functional index and the gastrocnemius muscle weight ratio, which were better than EPM group at 8 weeks and 12 weeks post operation. Immunofluorescence and Western blot results of P75NTR showed that Salidroside improved the sciatic nerve regeneration, and retrograded tracing of CTB-Alexa 488 also supported that Salidroside was better to promote CTB tracer transporting from the distal nerve defect to the ipsilateral dorsal root ganglion and ventral horn of L3-L5 spinal cord on post-operation 8 weeks and 12 weeks. Our results demonstrated that Salidroside improved the effect of autogenous epimysium conduit mixed with BD matrigel and RSC96 Schwann cells on sciatic nerve regeneration in our study. Impact statement Peripheral nerve injury and regeneration remain a major challenge. Although nerve conduit and Schwann cells have been used to study the nerve regeneration, our results demonstrated that Salidroside improved the regenerative effect in a rat model with sciatic nerve injury model, following a combined application of autogenous epimysium conduit mixed with Schwann cells. Different concentrations of Salidroside combining autogenous epimysium conduit and Schwann cells were applied to compare the epimysium conduit group and the epimysium conduit combining Schwann cells group. Based on the results of motor function and muscle reinnervation evaluation, as well as neuronal tracing and expression of P75NTR, our study for the first time suggests that Salidroside may improve the regeneration effect on the sciatic nerve following a combined application of epimysium conduit and RSC96 Schwann cells in rats.

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