pH-Sensitive Polymeric Nanoparticles Fabricated by Dispersion Polymerization for the Delivery of Bioactive Agents

pH responsive polymeric nanoparticles have emerged as a promising technology platform for targeted and controlled drug delivery in recent years. In this paper, endosomal pH-activatable doxorubicin (DOX) and core-crosslinked polymeric nanoparticles (DCNPs) were prepared and investigated for potent growth inhibition of human cancer cells in vitro. In vitro drug release studies, DOX conjugated nanoparticles with hydrazone bond showed a pH sensitive release phenomenon, that is, the releasing is significantly faster at mildly acidic condition with pH of 5.5 than that at physiological condition. Confocal laser scanning microscope (CLSM) observations revealed that DOX conjugated nanoparticles delivered and released DOX into the cytosols as well as cell nuclei of Hela cells following 6 h incubation. MTT assays demonstrated that these pH-sensitive DOX nanoparticles exhibited high antitumor effect to HeLa cells. The conjugated DOX polymeric nanoparticles may be a promising candidate as a nanoscale and pH-sensitive drug delivery vehicle for cancer therapy.

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pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities

Acta Biomaterialia ◽

10.1016/j.actbio.2017.04.029 ◽

2017 ◽

Vol 58 ◽

pp. 349-364 ◽

Cited By ~ 78

Author(s):

Jinming Zhang ◽

Jingjing Li ◽

Zhi Shi ◽

Yang Yang ◽

Xi Xie ◽

...

Keyword(s):

Polymeric Nanoparticles ◽

Ph Sensitive

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A New Strategy To Synthesize Temperature- and pH-Sensitive Multicompartment Block Copolymer Nanoparticles by Two Macro-RAFT Agents Comediated Dispersion Polymerization

Macromolecules ◽

10.1021/ma501598k ◽

2014 ◽

Vol 47 (21) ◽

pp. 7442-7452 ◽

Cited By ~ 40

Author(s):

Pengfei Shi ◽

Quanlong Li ◽

Xin He ◽

Shentong Li ◽

Pingchuan Sun ◽

...

Keyword(s):

Block Copolymer ◽

Dispersion Polymerization ◽

Ph Sensitive ◽

New Strategy

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Preparation and Characterization of Prussian Blue Coated Polymeric Nanoparticles via Dispersion Polymerization Template

Journal of Inorganic and Organometallic Polymers and Materials ◽

10.1007/s10904-020-01625-3 ◽

2020 ◽

Vol 30 (12) ◽

pp. 5074-5084

Author(s):

Lin Wu ◽

Tao Pang ◽

Laxia Wu ◽

Yebin Guan ◽

Liwei Yin ◽

...

Keyword(s):

Prussian Blue ◽

Dispersion Polymerization ◽

Polymeric Nanoparticles

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Nanoparticle-Mediated Therapeutic Approach for Ulcerative Colitis Treatment

Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-7998-3580-6.ch005 ◽

2021 ◽

pp. 96-117

Author(s):

Subhamoy Banerjee

Keyword(s):

Ulcerative Colitis ◽

Drug Delivery ◽

Polymeric Nanoparticles ◽

Oral Route ◽

Alternative Methods ◽

Active Components ◽

Life Threatening ◽

Ulcerative Colitis Treatment ◽

Inflammatory Bowel ◽

Bioactive Agents

Ulcerative colitis is a chronic inflammation of the inner part of the colonic mucosa. It is a type of inflammatory bowel disease which is idiopathic in nature. It is multifactorial, debilitating disorder which may cause life threatening complications. Given to the architecture of colon, conventional medicines have limitation in treating the disease. Thus, the need for alternative methods of drug delivery is important. Nanoparticle is one of the preferred drug delivery system owing to its unique properties. Nanoparticles resist undesired and premature degradation of the drugs, increases bioavailability, and target specificity. Different nanoparticle-based drug delivery systems like metallic, liposome, silica, or polymeric nanoparticles have been designed to administer therapeutic agents through oral route to treat ulcerative colitis. Natural compounds and active components isolated from the plant extracts and other bioactive agents are also delivered by nanoparticle. In the current chapter, nanoparticle-mediated drug and phytochemicals delivery to treat ulcerative colitis are discussed.

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