Faculty Opinions recommendation of CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data.

2018 ◽  
Author(s):  
Joost Haan
Keyword(s):  
Systematic Review ◽  
Cluster Headache ◽  
Clinical Data ◽  
Preventive Therapy

CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data

Cephalalgia ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 374-389 ◽  
Author(s):  
Sabrina Khan ◽  
Astrid Olesen ◽  
Messoud Ashina
Keyword(s):  
Monoclonal Antibodies ◽  
Cluster Headache ◽  
Phase Ii ◽  
Clinical Data ◽  
Therapeutic Option ◽  
Preventive Treatment ◽  
Cardiovascular Effects ◽  
Preventive Therapy ◽  
Phase Iii ◽  
Phase Ii And Iii

Introduction Migraine and cluster headache are challenging to manage, with no tailored preventive medications available. Targeting the calcitonin gene-related peptide (CGRP) pathway to treat these headaches may be the first focused therapeutic option to date, with the potential for promising efficacy. Methods We systematically searched PubMed and clinicaltrials.gov for randomized controlled trials investigating the preventive potential of monoclonal antibodies against the CGRP pathway in the treatment of migraine and cluster headache. Results The literature search returned a total of 136 records, of which 32 were eligible for review. Discussion Clinical data from phase II and III trials of the four monoclonal antibodies targeting the CGRP pathway: Eptinezumab, erenumab, fremanezumab, and galcanezumab, collectively show a positive effect in the preventive treatment of episodic and chronic migraine. Multiple phase II and III trials are under way to further determine the efficacy and safety of this new drug class. It may be particularly important to assess the cardiovascular effects of long-term CGRP blockade. Phase III trials are also currently in progress for the preventive treatment of cluster headache. Conclusion Efficacy of anti-CGRP monoclonal antibodies spells a promising future for the many patients suffering from migraine, and possibly also for the smaller but severely-affected population with cluster headache.

Cluster headache in children and adolescents: a systematic review of case reports

2021 ◽  
Author(s):  
Sarah N M A N Bastos ◽  
Bárbara L F Barbosa ◽  
Sângela F Silva ◽  
Ana G Krymchantowski ◽  
Carla Jevoux ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cluster Headache ◽  
Children And Adolescents ◽  
Case Reports

scholarly journals A systematic review and meta-analysis protocol examining the clinical characteristics and epidemiological features of olfactory dysfunction (OD) in coronavirus disease 2019 (COVID-19)

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Rosemond Qian-Xiu Tan ◽  
Wai Tak Victor Li ◽  
Wing-Zi Shum ◽  
Sheung Chit Chu ◽  
Hang-Long Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Data ◽  
Systematic Reviews ◽  
Clinical Characteristics ◽  
Meta Analysis ◽  
Olfactory Dysfunction ◽  
Statistical Analyses ◽  
Human Populations ◽  
Meta Analyses ◽  
Analysis Protocol

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has caused recurring and major outbreaks in multiple human populations around the world. The plethora of clinical presentations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been described extensively, of which olfactory dysfunction (OD) was established as an important and common extrapulmonary manifestation of COVID-19 infection. The aim of this protocol is to conduct a systematic review and meta-analysis on peer-reviewed articles which described clinical data of OD in COVID-19 patients. Methods This research protocol has been prospectively registered with the Prospective Register of Systematic Reviews (PROSPERO; CRD42020196202). CINAHL, ClinicalTrials.gov, Cochrane Central, EMBASE, MEDLINE and PubMed, as well as Chinese medical databases China National Knowledge Infrastructure (CNKI), VIP and WANFANG, will be searched using keywords including ‘COVID-19’, ‘coronavirus disease’, ‘2019-nCoV’, ‘SARS-CoV-2’, ‘novel coronavirus’, ‘anosmia’, ‘hyposmia’, ‘loss of smell’, and ‘olfactory dysfunction’. Systematic review and meta-analysis will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) guidelines. Articles will be screened according to pre-specified inclusion and exclusion criteria to extract studies that include new clinical data investigating the effect of COVID-19 on olfactory dysfunction. Included articles will be reviewed in full; data including patient demographics, clinical characteristics of COVID-19-related OD, methods of olfactory assessment and relevant clinical outcomes will be extracted. Statistical analyses will be performed using the Comprehensive Meta-Analysis version 3. Discussion This systematic review and meta-analysis protocol will aim to collate and synthesise all available clinical evidence regarding COVID-19-related OD as an important neurosensory dysfunction of COVID-19 infection. A comprehensive search strategy and screening process will be conducted to incorporate broad clinical data for robust statistical analyses and representation. The outcome of the systematic review and meta-analysis will aim to improve our understanding of the symptomatology and clinical characteristics of COVID-19-related OD and identify knowledge gaps in its disease process, which will guide future research in this specific neurosensory defect. Systematic review registration PROSPERO registration number: CRD42020196202.

Cluster headache: review of current understandings

2012 ◽  
pp. 5-12
Author(s):  
Reinaldo Teixeira Ribeiro ◽  
André Leite Gonçalves ◽  
Maria Eduarda Nobre ◽  
Deusvenir de Souza Carvalho ◽  
Mario Fernando Prieto Peres
Keyword(s):  
Systematic Review ◽  
Cluster Headache ◽  
The United States ◽  
Search Term ◽  
National Library ◽  
Trigeminal Autonomic Cephalalgia ◽  
Treatment Approaches ◽  
Source Data ◽  
Subsequent Reference ◽  
Tension Type Headaches

Cluster headache (CH) is the trigeminal autonomic cephalalgia whose pain is considered to be one of the most severe known to man. Although diagnosed less frequently than migraine and tension-type headaches, CH is nonetheless an important clinical entity, particularly given our evolving understanding of its actual epidemiology, pathophysiology, current diagnostic criteria and treatment approaches. We carried out a systematic review through the United States National Library of Medicine (PUBMED) by using the search term "cluster headache" and the results were narrowed to manuscripts published in the last ten years with subsequent reference searches and verification of source data. This article presents a review of the current understanding of the most important aspects of CH, with emphasis on mechanisms and treatment approaches.

Systematic Review of Clinical Data with BNO-101 (Sinupret?) in the Treatment of Sinusitis

2006 ◽  
Vol 13 (2) ◽  
pp. 78-87 ◽  
Author(s):  
Jörg Melzer ◽  
Reinhard Saller ◽  
Andreas Schapowal ◽  
Reto Brignoli
Keyword(s):  
Systematic Review ◽  
Clinical Data

scholarly journals The global prevalence of latent tuberculosis: a systematic review and meta-analysis

2019 ◽  
Vol 54 (3) ◽  
pp. 1900655 ◽  
Author(s):  
Adam Cohen ◽  
Victor Dahl Mathiasen ◽  
Thomas Schön ◽  
Christian Wejse
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Preventive Therapy ◽  
Incidence Rates ◽  
World Health ◽  
Global Prevalence ◽  
Ltbi Prevalence ◽  
Health Organization

In 1999, the World Health Organization (WHO) estimated that one-third of the world's population had latent tuberculosis infection (LTBI), which was recently updated to one-fourth. However, this is still based on controversial assumptions in combination with tuberculin skin test (TST) surveys. Interferon-γ release assays (IGRAs) with a higher specificity than TST have since been widely implemented, but never used to estimate the global LTBI prevalence.We conducted a systematic review and meta-analysis of LTBI estimates based on both IGRA and TST results published between 2005 and 2018. Regional and global estimates of LTBI prevalence were calculated. Stratification was performed for low, intermediate and high TB incidence countries and a pooled estimate for each area was calculated using a random effects model.Among 3280 studies screened, we included 88 studies from 36 countries with 41 IGRA (n=67 167) and 67 TST estimates (n=284 644). The global prevalence of LTBI was 24.8% (95% CI 19.7–30.0%) and 21.2% (95% CI 17.9–24.4%), based on IGRA and a 10-mm TST cut-off, respectively. The prevalence estimates correlated well to WHO incidence rates (Rs=0.70, p<0.001).In the first study of the global prevalence of LTBI derived from both IGRA and TST surveys, we found that one-fourth of the world's population is infected. This is of relevance, as both tests, although imperfect, are used to identify individuals eligible for preventive therapy. Enhanced efforts are needed targeting the large pool of latently infected individuals, as this constitutes an enormous source of potential active tuberculosis.

Cluster headache: crosspoint between otologists and neurologists—treatment of the sphenopalatine ganglion and systematic review

2019 ◽  
Vol 40 (S1) ◽  
pp. 137-146 ◽  
Author(s):  
Cecilia Rosso ◽  
Giovanni Felisati ◽  
Antonio Bulfamante ◽  
Carlotta Pipolo
Keyword(s):  
Systematic Review ◽  
Cluster Headache ◽  
Sphenopalatine Ganglion

scholarly journals Non-invasive vagus nerve stimulation for primary headache: A clinical update

Cephalalgia ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 1370-1384
Author(s):  
Stephen D Silberstein ◽  
Hsiangkuo Yuan ◽  
Umer Najib ◽  
Jessica Ailani ◽  
Andreia Lopes de Morais ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Clinical Evidence ◽  
Primary Headache ◽  
Preventive Therapy ◽  
Tolerability Profile ◽  
Clinical Effects ◽  
Non Invasive

Background Non-invasive vagus nerve stimulation (nVNS) is a proven treatment for cluster headache and migraine. Several possible mechanisms of action by which nVNS mitigates headache have been identified. Methods We conducted a narrative review of recent scientific and clinical research into nVNS for headache, including findings from mechanistic studies and their possible relationships to the clinical effects of nVNS. Results Findings from animal and human studies have provided possible mechanistic explanations for nVNS efficacy in headache involving four core areas: Autonomic nervous system functions; cortical spreading depression inhibition; neurotransmitter regulation; and nociceptive modulation. We discuss how overlap and interplay among these areas may underlie the utility of nVNS in the context of clinical evidence supporting its safety and efficacy as acute and preventive therapy for both cluster headache and migraine. Possible future nVNS applications are also discussed. Conclusion Significant progress over the past several years has yielded valuable mechanistic and clinical evidence that, combined with the excellent safety and tolerability profile of nVNS, suggests that it should be considered a first-line treatment for both acute and preventive treatment of cluster headache, an effective option for acute treatment of migraine, and a highly relevant, practical option for migraine prevention.

Definitions and participant characteristics of frequent recurrent headache types in clinical trials: A systematic review

Cephalalgia ◽  
2017 ◽  
Vol 38 (4) ◽  
pp. 786-793 ◽  
Author(s):  
Maria-Eliza R Aguila ◽  
Trudy Rebbeck ◽  
Kristofferson G Mendoza ◽  
Mary-Grace L De La Peña ◽  
Andrew M Leaver
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Cluster Headache ◽  
Cervicogenic Headache ◽  
Tension Type Headache ◽  
Inclusion Criteria ◽  
Recurrent Headache ◽  
Episode Frequency ◽  
Type Headache

Background Clear definitions of study populations in clinical trials may facilitate application of evidence to clinical populations. This review aimed to explore definitions of study populations in clinical trials on migraine, tension-type headache, cluster headache, and cervicogenic headache. Methods We performed a systematic review of clinical trials investigating treatment efficacy for migraine, tension-type headache, cluster headache, and cervicogenic headache. We extracted data on diagnosis, inclusion criteria and baseline headache characteristics. Results Of the 229 studies reviewed, 205 studies (89.5%) defined their populations in adherence to the International Classification of Headache Disorders (ICHD) criteria. Some studies ( n = 127, 55.5%) specified diagnosing through interview, clinical examination and diary entry. The most commonly reported inclusion criteria were pain intensity for migraine and tension-type headache studies ( n = 123, 66.1% and n = 21, 67.7%, respectively), episode frequency ( n = 5, 71.4%) for cluster headache studies, and neck-related pain for cervicogenic headache studies ( n = 3, 60%). Few studies reported details on the extent to which diagnostic criteria were present at baseline. Conclusions ICHD is routinely used in defining populations in headache studies. Details of baseline headache characteristics were not as consistently reported.

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