scholarly journals Faculty Opinions recommendation of Single olfactory receptors set odor detection thresholds.

Author(s):  
Charles Greer
2018 ◽  
Author(s):  
Adam Dewan ◽  
Annika Cichy ◽  
Jingji Zhang ◽  
Kayla Miguel ◽  
Paul Feinstein ◽  
...  

ABSTRACTIn many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here, we examine how a conserved subset of olfactory receptors, the trace amine-associated receptors (TAARs) determine odor detection thresholds of mice to amines. We find that deleting all TAARs, or even single TAARs, results in significant odor detection deficits. This finding is not limited to TAARs, as the deletion of a canonical odorant receptor reduced behavioral sensitivity to its preferred ligand. Remarkably, behavioral threshold is set solely by the most sensitive receptor, with no contribution from other highly sensitive receptors. In addition, increasing the number of sensory neurons (and glomeruli) expressing a threshold-determining TAAR does not improve detection, indicating that sensitivity is not limited by the typical complement of sensory neurons. Our findings demonstrate that olfactory thresholds are set by the single highest affinity receptor, and suggest that TAARs are evolutionarily conserved because they determine the sensitivity to a class of biologically relevant chemicals.


2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Adam Dewan ◽  
Annika Cichy ◽  
Jingji Zhang ◽  
Kayla Miguel ◽  
Paul Feinstein ◽  
...  

2008 ◽  
Vol 122 (4) ◽  
pp. 788-793 ◽  
Author(s):  
Krystina G. Sorwell ◽  
Daniel W. Wesson ◽  
Michael J. Baum

1981 ◽  
Vol 6 (4) ◽  
pp. 421-433 ◽  
Author(s):  
David A. Marshall ◽  
Richard L. Doty ◽  
Daniel P. Lucero ◽  
Burton M. Slotnick

Foods ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 176 ◽  
Author(s):  
Marianne McKay ◽  
Florian Bauer ◽  
Valeria Panzeri ◽  
Astrid Buica

The odor detection threshold (ODT) of a compound is the lowest concentration at which individuals can reliably perceive a difference between a sample and its corresponding control, with 50% performance above chance. Wine is a complex matrix, and ODTs used in studies on wine can be based on inappropriate matrices and informal sensory methodologies. Formal studies confirming ODTs in wine are relatively scarce in the literature, and are complex and expensive to carry out. In this study, the sensitivity of panelists to previously published ODTs for five compounds: Guaiacol, o-cresol and 4-ethyl phenol, 3-isobutyl-2-methoxypyrazine (IBMP), and 2,4,6-trichloroanisole (TCA) associated with off-flavor/taint issues in wine, was investigated. The study was carried out in partially de-aromatized young Shiraz wine (unwooded) using a simplified version of the formal sensory approach. A triangle test in triplicate was carried out with 34 panelists, at the ODT for each compound, in one day. The study explored whether previous training affected panelists’ sensitivity for threshold differences. Results showed that samples spiked with volatile phenols were significantly different (p = 0.01) to controls. The spiked TCA and IBMP samples were not significantly different from the control in either case. Judges were better able to detect compounds if they had prior experience or training in wine evaluation. Despite some limitations, this pragmatic approach may be useful when carrying out sensory studies with fairly limited resources and within tight timelines, as it provides helpful information on panel members and detection thresholds for a specific matrix.


2016 ◽  
Vol 127 (6) ◽  
pp. 1257-1262 ◽  
Author(s):  
Carla R. Schubert ◽  
Mary E. Fischer ◽  
A. Alex Pinto ◽  
Barbara E. K. Klein ◽  
Ronald Klein ◽  
...  

PeerJ ◽  
2014 ◽  
Vol 2 ◽  
pp. e643 ◽  
Author(s):  
Gillian R. Cook ◽  
S Krithika ◽  
Melissa Edwards ◽  
Paula Kavanagh ◽  
Esteban J. Parra

Sign in / Sign up

Export Citation Format

Share Document