Faculty Opinions recommendation of The role of bradykinin receptors in the etiopathogenesis of chronic spontaneous urticaria.

Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin. Recently, CSU has been associated with bradykinin release, which was previously discovered to be the main trigger of hereditary angioedema attacks. To study the role of bradykinin receptors 1 (BR1) and 2 (BR2) in the etiopathogenesis of CSU. Materials and Methods: A total of 60 individuals, 30 patients with CSU and 30 healthy subjects, were recruited to the study. CSU was diagnosed in accordance with the standardized protocol of dermatological assessment of skin symptoms. The level of bradykinin receptors was determined in populations of CD3+, CD4+, and CD8+ lymphocytes as well as in CD14++CD16−, CD14++CD16+ and CD14+CD16+ monocytes. In addition, urticaria activity score summed over 7 days (UAS-7) was assessed and correlated with BR1 and BR2 expression. Results: A statistically significant higher concentration of BR1 expression in lymphocytes was found in patients with CSU, compared to the control group (p < 0.001). Moreover, a statistically significant positive correlation was observed between UAS-7 and BR1/BR2 expression in CD14++CD16− cells (p = 0.03, R = 0.4). Conclusions: Bradykinin receptors are elevated in selected populations of lymphocytes in symptomatic CSU patients compared to healthy controls, indicating their role in the etiopathogenesis of the disease.

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The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells

The Journal of Allergy and Clinical Immunology In Practice ◽

10.1016/j.jaip.2021.03.033 ◽

2021 ◽

Author(s):

Ana M. Giménez-Arnau ◽

Laurence DeMontojoye ◽

Riccardo Asero ◽

Massimo Cugno ◽

Kanokvalai Kulthanan ◽

...

Keyword(s):

Chronic Spontaneous Urticaria ◽

Infiltrating Cells

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The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria

Cells ◽

10.3390/cells10071759 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1759

Author(s):

Yuhki Yanase ◽

Shunsuke Takahagi ◽

Koichiro Ozawa ◽

Michihiro Hide

Keyword(s):

Mast Cells ◽

Cell Activation ◽

Coagulation Factors ◽

Chronic Spontaneous Urticaria ◽

Mast Cell Activation ◽

Coagulation Cascade ◽

Edema Formation ◽

Complement Components ◽

Complement Factors

Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by an almost daily recurrence of wheal and flare with itch for more than 6 weeks, in association with the release of stored inflammatory mediators, such as histamine, from skin mast cells and/or peripheral basophils. The involvement of the extrinsic coagulation cascade triggered by tissue factor (TF) and complement factors, such as C3a and C5a, has been implied in the pathogenesis of CSU. However, it has been unclear how the TF-triggered coagulation pathway and complement factors induce the activation of skin mast cells and peripheral basophils in patients with CSU. In this review, we focus on the role of vascular endothelial cells, leukocytes, extrinsic coagulation factors and complement components on TF-induced activation of skin mast cells and peripheral basophils followed by the edema formation clinically recognized as urticaria. These findings suggest that medications targeting activated coagulation factors and/or complement components may represent new and effective treatments for patients with severe and refractory CSU.

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Bradykinin –induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors

Peptides ◽

10.1016/j.peptides.2016.09.001 ◽

2016 ◽

Vol 85 ◽

pp. 46-55 ◽

Cited By ~ 16

Author(s):

A. Siltari ◽

R. Korpela ◽

H. Vapaatalo

Keyword(s):

Bradykinin Receptors ◽

Inhibitory Peptide

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The role of increased T helper cell 2 cytokine expression in skin weals of chronic spontaneous urticaria: are they always activating cytokines?

British Journal of Dermatology ◽

10.1111/bjd.13784 ◽

2015 ◽

Vol 172 (5) ◽

pp. 1185-1186

Author(s):

Z. Vadasz ◽

E. Toubi

Keyword(s):

Cytokine Expression ◽

T Helper Cell ◽

Chronic Spontaneous Urticaria ◽

Helper Cell ◽

T Helper

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Bradykinin receptors localized by quantitative autoradiography in kidney, ureter, and bladder

AJP Renal Physiology ◽

10.1152/ajprenal.1989.256.5.f909 ◽

1989 ◽

Vol 256 (5) ◽

pp. F909-F915 ◽

Cited By ~ 4

Author(s):

D. C. Manning ◽

S. H. Snyder

Keyword(s):

Guinea Pig ◽

Binding Sites ◽

Basal Membrane ◽

Epithelial Layer ◽

Bradykinin Receptors ◽

High Affinity ◽

Collecting Tubule ◽

Tubule Cells

We have localized high affinity [3H]bradykinin receptor binding sites by in vitro autoradiography in kidney, ureter, and bladder of the guinea pig. The peptide pharmacology of the binding sites corresponds to that of high affinity physiological bradykinin receptors previously described (Manning, D. C., R. Vavrek, J. M. Stewart, and S. H. Snyder. J. Pharmacol. Exp. Ther. 237:504-512, 1986). In the kidney, receptors are concentrated in the medulla with negligible binding in the cortex. Medullary receptors are localized to the interstitium just beneath the basal membrane of collecting tubule cells and between tubules. In the ureter and bladder, receptors are confined to the lamina propria just beneath the epithelial layer. Localizations in the kidney may relate to the diuretic and natriuretic actions of bradykinin. Ureteral and bladder receptors may be associated with a role of bradykinin in pain and inflammation.

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