Enxerto ósseo sintético em reparo de defeitos ósseos em paciente pediátrico: Relato de caso / Synthetic bone graft in bone defect repair in pediatric patient: Case re-port

Over the last few years, various bone graft materials of bovine origin to be used in oromaxillofacial surgeries have entered the market. In the present study, we determined the capacity of a block organic bone graft material (Gen-ox, Baumer SA, Brazil) prepared from bovine cancellous bone to promote the repair of critical size bone injuries in rat calvaria. A transosseous defect measuring approximately 8mm in diameter was performed with a surgical trephine in the parietal bone of 25 rats. In 15 animals, the defects were filled with a block of graft material measuring 8mm in diameter and soaked in the animal's own blood, and in the other 10 animals the defects were only filled with blood clots. The calvariae of rats receiving the material were collected 1, 3 and 6 months after surgery, and those of animals receiving the blood clots were collected immediately and 6 months after surgery. During surgery, the graft material was found to be of easy handling and to adapt perfectly to the receptor bed after soaking in blood. The results showed that, in most animals treated, the material was slowly resorbed and served as a space filling and maintenance material, favoring angiogenesis, cell migration and adhesion, and bone neoformation from the borders of the lesion. However, a foreign body-type granulomatous reaction, with the presence of numerous giant cells preventing local bone neoformation, was observed in two animals of the 1-month subgroup and in one animal of the 3-month subgroup. These cases were interpreted as resulting from the absence of demineralization and the lack of removal of potential antigen factors during production of the biomaterial. We conclude that, with improvement in the quality control of the material production, block organic bone matrix will become a good alternative for bone defect repair in the oromaxillofacial region due to its high osteoconductive capacity.

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Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur

Apmis ◽

10.1111/apm.12918 ◽

2019 ◽

Vol 127 (2) ◽

pp. 53-63 ◽

Cited By ~ 4

Author(s):

Werner Hettwer ◽

Peter F. Horstmann ◽

Sabine Bischoff ◽

Daniel Güllmar ◽

Jürgen R. Reichenbach ◽

...

Keyword(s):

Bone Graft ◽

Bone Defect ◽

Critical Size ◽

Bone Graft Substitute ◽

Defect Model ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Metaphyseal Bone

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405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

British Journal of Surgery ◽

10.1093/bjs/znab134.273 ◽

2021 ◽

Vol 108 (Supplement_2) ◽

Author(s):

A Aljawadi ◽

I Madhi ◽

T Naylor ◽

M Elmajee ◽

A Islam ◽

...

Keyword(s):

Bone Graft ◽

Cortical Thickness ◽

Bone Graft Substitute ◽

Fracture Site ◽

Open Fractures ◽

X Rays ◽

Radiographic Images ◽

Synthetic Bone ◽

Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

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Design and characterization of injectable abalone shell/calcium sulfate bone cement scaffold for bone defect repair

Chemical Engineering Journal ◽

10.1016/j.cej.2021.129866 ◽

2021 ◽

Vol 420 ◽

pp. 129866

Author(s):

Mingzu Du ◽

Qian Li ◽

Jingdi Chen ◽

Kaihua Liu ◽

Cui Song

Keyword(s):

Bone Cement ◽

Bone Defect ◽

Calcium Sulfate ◽

Bone Defect Repair ◽

Defect Repair ◽

Abalone Shell

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Bone defect repair on the alveolar wall of the maxillary sinus using collagen membranes and temporal fascia: an experimental study in monkeys

Brazilian Journal of Otorhinolaryngology ◽

10.1590/s1808-86942011000400006 ◽

2011 ◽

Vol 77 (4) ◽

pp. 439-446 ◽

Cited By ~ 1

Author(s):

Adalberto Novaes Silva ◽

José Américo de Oliveira ◽

Maria Célia Jamur ◽

José Ari Gualberto Junqueira ◽

Vani Maria Correa ◽

...

Keyword(s):

Experimental Study ◽

Maxillary Sinus ◽

Bone Defect ◽

Alveolar Wall ◽

Bone Defect Repair ◽

Temporal Fascia ◽

Defect Repair ◽

Collagen Membranes

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Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

Journal of Materials Chemistry B ◽

10.1039/d1tb00184a ◽

2021 ◽

Author(s):

Xinyun Zhai ◽

Changshun Ruan ◽

Jie Shen ◽

Chuping Zheng ◽

Xiaoli Zhao ◽

...

Keyword(s):

Mechanical Properties ◽

Bone Defect ◽

Nanocomposite Hydrogel ◽

Ion Release ◽

Bone Defect Repair ◽

Defect Repair ◽

Gradual Release

Using nanoclay as the physical crosslinker, a novel clay-based nanocomposite hydrogel with attractive mechanical properties has be obtained, and the gradual release of intrinsic Mg2+ and Si4+ endows the system with excellent osteogenesis.

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Test yourself answer: supra-acetabular pelvis synthetic bone graft substitute (CERAMENT) with expected resorption of radiopaque graft material

Skeletal Radiology ◽

10.1007/s00256-020-03431-x ◽

2020 ◽

Vol 49 (8) ◽

pp. 1329-1330

Author(s):

Molly B. Carnahan ◽

Jeremiah R. Long

Keyword(s):

Bone Graft ◽

Bone Graft Substitute ◽

Graft Material ◽

Synthetic Bone ◽

Synthetic Bone Graft

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Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

Journal of Neurosurgery Spine ◽

10.3171/2016.1.spine151005 ◽

2016 ◽

Vol 25 (4) ◽

pp. 509-516 ◽

Cited By ~ 51

Author(s):

Zorica Buser ◽

Darrel S. Brodke ◽

Jim A. Youssef ◽

Hans-Joerg Meisel ◽

Sue Lynn Myhre ◽

...

Keyword(s):

Systematic Review ◽

Cohort Studies ◽

Bone Graft ◽

Spinal Fusion ◽

Comparative Studies ◽

Functional Outcomes ◽

Retrospective Studies ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

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