scholarly journals Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?

2020 ◽  
Vol 9 (2) ◽  
pp. e12-e12
Author(s):  
Aiyoub Pezeshgi ◽  
Alireza Behmanesh ◽  
Abdolreza Esmaeilzadeh ◽  
Hossein Chiti ◽  
Kurosh Kamali ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Kidney Injury ◽  
Coronary Bypass ◽  
Urinary Ngal ◽  
Artery Bypass Graft ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Post Surgery ◽  
Neutrophil Gelatinase

Introduction: The role of urinary neutrophil gelatinase-associated lipocalin (NGAL) as a prognostic biomarker in acute kidney injury (AKI) associated with coronary bypass graft has been suggested in some studies. However, the results have been inconclusive in different studies. Objectives: In the present research, we investigated the diagnostic and prognostic roles of NGAL in Iranian patients who developed AKI after coronary bypass surgery. Patients and Methods: This study was cross-sectional conducted on adult patients undergoing coronary artery bypass graft (CABG) surgery. Postoperative AKI was defined based on the RIFLE (risk, injury, failure, loss and end-stage kidney disease) criteria. Patients were divided into AKI and non-AKI groups. The urinary NGAL and serum creatinine levels were measured at different times after surgery. Results: Out of 29 patients, men constituted 75.9% of cases. Mean age of the patients was 61.4±7.7 years old and the mean duration of surgery was 4.9±0.6 hours. Based on serum creatinine, AKI was diagnosed in 37.9%, 17.25%, and 13.8% of patients at first, second, and third day post-surgery, respectively. The urine NGAL increased by 48.35% and 34.5% at 2 and 6 hours after surgery, respectively. However, there was no significant association between the urinary NGAL level and the incidence of post-surgery AKI. Conclusion: This study showed that urinary NGAL was inapplicable to independently diagnose or predict the outcome of transient AKI associated with CABG.

scholarly journals Plasma Neutrophil Gelatinase-Associated Lipocalin and Interleukin-9 as Acute Kidney Injury Predictors After Coronary Artery Bypass Graft Following Cardiopulmonary Bypass

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Ghuraba Adisurya ◽  
Kun Arifi Abba ◽  
Nancy Margarita Rehatta ◽  
Hardiono Hardiono
Keyword(s):  
Acute Kidney Injury ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Kidney Injury ◽  
Artery Bypass Graft ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Plasma Ngal ◽  
Cabg Patients ◽  
Neutrophil Gelatinase ◽  
Interleukin 9

Background: Acute Kidney Injury (AKI) incidence of postoperative Coronary Artery Bypass Graft (CABG) with Cardipulmonary Bypass (CPB) at Dr. Soetomo General Academic Hospital reached 69.8%, higher than the global average of 5-20%. Predictors of postoperative AKI are needed; potential biomarkers include plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Interleukin-9 (IL-9). This study aims to analyze the predictive ability of these two biomarkers. Methods: This is a prospective observational study in CABG patients with CPB without previous renal abnormalities at Dr. Soetomo in September-December 2020. Examination of plasma NGAL and IL-9 was carried out before, during, and after the CPB procedure. Results: 21 patients were included in the study, 17 people (81.0%) were male. AKI experienced 14 people (66.7%); 3 people (14.3%) died. Patients without AKI had higher plasma NGAL results at preinduction (17.9±10.3 vs 17.1±15.5), durante (20.5±8.2 vs 16.9±7.8), and early ICU (24.0±8.6 vs 22.9±10.4). Patients with AKI had higher plasma IL-9 results at preinduction (63.3±23.2 vs 55.7±15.8), durante (45.2±11.0 vs 44.2±9.2), and early ICU (49.6±11.3 vs 46.2±15.6). There was no statistically significant relationship between plasma NGAL and IL-9 results. Conclusion: Most CABG patients undergoing CPB have AKI. Patients without AKI had higher NGAL results and lower IL-9 in plasma. Statistically, neither of them can be used as predictive biomarkers of the incidence of AKI so far.

scholarly journals The Incidence and Risk Factors of Acute Kidney Injury After Coronary Artery Bypass Graft Surgery

2015 ◽  
Vol 1 (3) ◽  
Author(s):  
Samira Tabiban ◽  
Turaj Babaee ◽  
Behshid Ghadrdoost ◽  
Hooman Bakhshandeh ◽  
Ali Sadeghpour Tabaei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Kidney Injury ◽  
Artery Bypass Graft

Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study

2017 ◽  
Vol 31 (6) ◽  
pp. 2080-2085 ◽  
Author(s):  
Valery V. Likhvantsev ◽  
Giovanni Landoni ◽  
Oleg A. Grebenchikov ◽  
Yuri V. Skripkin ◽  
Tatiana S. Zabelina ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Coronary Artery ◽  
Pilot Study ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Nuclear Dna ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Kidney Injury ◽  
Artery Bypass Graft

scholarly journals Acute kidney injury after a coronary artery bypass graft surgery

2021 ◽  
Vol 5 (3) ◽  
pp. 204
Author(s):  
KunArifi Abbas ◽  
NancyMargarita Rehatta ◽  
YanEfrata Sembiring ◽  
Ghuraba Adisurya ◽  
PranandaSurya Airlangga ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Kidney Injury ◽  
Artery Bypass Graft

scholarly journals Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery

2020 ◽  
Vol 10 (1) ◽  
pp. e04-e04
Author(s):  
Maryam Saeedi Ghaheh ◽  
Saeed Mardani ◽  
Afsaneh Malekpour ◽  
Farzaneh Kadkhodaei Elyaderani ◽  
Fatemeh Salehi Choliche ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Serum Creatinine ◽  
Coronary Artery Bypass Graft ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Kidney Injury ◽  
High Ability ◽  
Urinary Ngal ◽  
Artery Bypass Graft ◽  
Significant Difference

Introduction: Serum creatinine level is currently being used as an indicator to detect acute kidney injury (AKI) after cardiac surgery, which is delayed and unreliable. Objectives: This study was conducted to determine the AKI in patients undergoing coronary artery bypass graft (CABG) surgery by measurement of urinary creatinine and plasma kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Patients and Methods: In this cross-sectional study, 96 patients undergoing CABG were divided based on their serum creatinine level of the fourth day after procedure into two groups of AKI (an increase of creatinine more than 0.3 mg/dl or more than 150 % of its baseline level) and non-AKI. In both groups urinary KIM-1 and urinary NGAL were measured on the first day of surgery (first 24 h). Results: No significant difference was observed in baseline creatinine between the two groups (P>0.05). However postoperative serum creatinine, creatinine changes, urinary NGAL and KIM1 showed significant difference between the groups (P<0.05). Serum creatinine was positively correlated with KIM-1 (r = 0.666, P<0.001) and NGAL (r = 0.660, P<0.001). KIM-1 and NGAL had high ability to detect AKI [area under the ROC (receiver operating characteristic) curve of 0.929 and 0.838, respectively]. The NGAL at cut-off point of 97.4 had 86% sensitivity and 80% specificity and KIM-1 at cut-off point of 14.8 had 84% sensitivity and 89% specificity. Conclusion: KIM-1 and NGAL had high ability to detect AKI. However, KIM-1 had higher detection ability than that of NGAL.

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