scholarly journals Long-term effects of hyperproteic diet on functional renal reserve and natriuresis

2020 ◽  
Vol 10 (2) ◽  
pp. e13-e13
Author(s):  
Edwin R. Castillo Velarde
Keyword(s):  
Creatinine Clearance ◽  
Diet Group ◽  
Long Term Effects ◽  
Functional Reserve ◽  
High Sodium ◽  
Renal Functional Reserve ◽  
Plant Source ◽  
Animal Source ◽  
Subsequent Decrease

Introduction: A hyperproteic diet normally results in acute changes in renal function evidenced by increases of natriuresis and glomerular filtration rate (renal functional reserve).Objectives: To assess the changes in natriuresis and creatinine clearance during 12 weeks on hyperproteic and hypersodic diet. Materials and Methods: Eighteen adults male Holtzman rats were included and the follow-up period was 12 weeks. The rats were initially distributed into three groups; hyperproteic diet (30%) from an animal source (n = 6), hyperproteic diet (30%) from a plant source (n = 6) and normoproteic diet (18%) from an animal source (n = 6). The diets were isocaloric, normosodic (0.25%). From week 8, each group was divided into three rats each and received a high-sodium (1.5%) and normosodic diet (0.25%) respectively. Results: The hyperproteic diet group (animal or plant vegetal source) had higher creatinine clearance than normoproteic diet (P < 0.05). The hyperproteic vegetal diet group had a peak with an increased renal functional reserve in 21% (P = 0.04). The natriuresis increased in the group on the animal-source diet during the first 2 weeks (P = 0.03). The group plant-source diet did not have significant change at the first week (P = 0.50); however, there was a subsequent decrease in the level of natriuresis between weeks 3 to 8. When the groups were exposed to a hypersodic diet, there was not difference in the natriuretic response between the groups (P > 0.05). Conclusion: A hyperproteic vegetal diet increased renal functional reserve but not natriuresis during an acute or long-term period; however, the natriuretic response was not impaired when a hypersodic diet was added, though hyperfiltration was present.

Restrictions on Use of Creatinine Clearance for Measurement of Renal Functional Reserve

Nephron ◽  
1989 ◽  
Vol 51 (2) ◽  
pp. 233-236 ◽  
Author(s):  
Maurice Laville ◽  
Aoumeur Hadj-Aissa ◽  
Nicole Pozet ◽  
Jean-Hervé Le Bras ◽  
Michel Labeeuw ◽  
...  
Keyword(s):  
Creatinine Clearance ◽  
Functional Reserve ◽  
Renal Functional Reserve

LONG-TERM FOLLOWUP OF RENAL FUNCTIONAL RESERVE CAPACITY AFTER UNILATERAL NEPHRECTOMY IN CHILDHOOD

1998 ◽  
Vol 160 (3 Part 1) ◽  
pp. 844-848 ◽  
Author(s):  
BIANCA M. REGAZZONI ◽  
NOEL GENTON ◽  
JACQUELINE PELET ◽  
ALFRED DRUKKER ◽  
JEAN-PIERRE GUIGNARD
Keyword(s):  
Unilateral Nephrectomy ◽  
Reserve Capacity ◽  
Functional Reserve ◽  
Renal Functional Reserve

Atrial natriuretic factor and blood pressure control: role of sodium and aldosterone

1990 ◽  
Vol 259 (5) ◽  
pp. R973-R980 ◽  
Author(s):  
C. A. Gaillard ◽  
H. L. Mizelle ◽  
J. P. Montani ◽  
M. W. Brands ◽  
D. A. Hildebrandt ◽  
...  
Keyword(s):  
Sodium Excretion ◽  
Atrial Natriuretic Factor ◽  
Sodium Intake ◽  
Control Period ◽  
Hypotensive Effect ◽  
Long Term Effects ◽  
High Sodium ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

This study examined the long-term actions of atrial natriuretic factor (ANF), at physiological levels, on renal function and mean arterial pressure (MAP) and the importance of Na intake and the renin-angiotensin-aldosterone system in modulating those effects. After a control period, ANF was infused intravenously at a rate of 10 ng.kg-1.min-1 for 7 days, followed by 7 days of 20 ng.kg-1.min-1 and 7 days of recovery. After 7 days of ANF at 10 ng.kg-1.min-1, MAP decreased from 87 +/- 3 to 80 +/- 2 mmHg in normal dogs on low sodium intake (LS, 7 meq Na/day) and from 89 +/- 2 to 79 +/- 2 mmHg in adrenalectomized dogs (ADX, 7 meq Na/day) given constant mineralocorticoid replacement. In both groups, no significant change in glomerular filtration rate (GFR) was observed, although sodium excretion increased transiently. ANF failed to cause significant changes in MAP, GFR, or sodium excretion in normal dogs on high sodium intake (HS, 269 meq Na/day). In LS and HS no long-term effects of ANF on plasma renin activity (PRA) and aldosterone were observed. In ADX, as expected, no change in aldosterone was observed. Thus, in normal and adrenalectomized dogs on LS, chronic ANF infusion caused sustained reductions in MAP. HS markedly attenuated the hypotensive effect of ANF. Our data suggest that the long-term effect of ANF is salt sensitive but that decreases in PRA and aldosterone are not essential for the long-term hypotensive effect of ANF.

Renal functional reserve in long-term survivors of unilateral Wilms tumor

1991 ◽  
Vol 118 (5) ◽  
pp. 698-702 ◽  
Author(s):  
Donna M. Bhisitkul ◽  
Elaine R. Morgan ◽  
Michele A. Vozar ◽  
Craig B. Langman
Keyword(s):  
Wilms Tumor ◽  
Functional Reserve ◽  
Renal Functional Reserve ◽  
Long Term Survivors

scholarly journals Short- and Long-Term Functional Effects of Percutaneous Transluminal Angioplasty in Hemodialysis Vascular Access

2002 ◽  
Vol 13 (3) ◽  
pp. 715-720 ◽  
Author(s):  
Joke van der Linden ◽  
Johannes H. M. Smits ◽  
Jan H. Assink ◽  
Derk W. Wolterbeek ◽  
Jan J. Zijlstra ◽  
...  
Keyword(s):  
Percutaneous Transluminal Angioplasty ◽  
Transluminal Angioplasty ◽  
Optimal Timing ◽  
Long Term Effects ◽  
Short Term ◽  
Ultrasound Dilution ◽  
Subsequent Decrease ◽  
Angiographic Result ◽  
Percutaneous Transluminal

ABSTRACT. The efficacy of percutaneous transluminal angioplasty (PTA) is usually expressed as the angiographic result. Access flow (Qa) measurements offer a means to quantify the functional effects. This study was performed to evaluate the short-term functional and angiographic effects of PTA and to determine the longevity of the functional effects during the follow-up period. Patients with an arteriovenous graft (AVG) or an arteriovenous fistula (AVF) who were eligible for PTA (Qa values of <600 ml/min) were included. Ultrasound-dilution Qa measurements were obtained shortly before PTA and periodically after PTA, beginning 1 wk after the procedure. The short-term effects were expressed as the increase in Qa and the reduction of stenosis. The long-term effects were expressed as patency and the decrease in Qa after PTA. Ninety-eight PTA procedures for 60 patients (65 AVG and 33 AVF) were analyzed. Qa improved from 371 ± 17 to 674 ± 30 ml/min for AVG and from 304 ± 24 to 638 ± 51 ml/min for AVF (both P < 0.0001). In 66% (AVG) and 50% (AVF) of cases, Qa increased to levels of >600 ml/min. The degree of stenosis decreased from 65 ± 3 to 17 ± 2% for AVG and from 72 ± 5 to 23 ± 7% for AVF (both P < 0.005). The reduction of stenosis was not correlated with ΔQa (r2 = 0.066). Six-month unassisted patency rates after PTA were 25% for AVG and 50% for AVF. The decreases in Qa were 3.7 ± 0.8 ml/min per d for AVG and 1.8 ± 0.9 ml/min per d for AVF. Qa values before PTA and ΔQa were correlated with the subsequent decrease in Qa (P < 0.005). In conclusion, Qa increases after PTA but, in a substantial percentage of cases, not to levels of >600 ml/min. Qa values before PTA and the increase in Qa were correlated with long-term outcomes, whereas angiographic results were not. These data, combined with literature data, suggest that there is optimal timing for PTA.

scholarly journals Renal functional reserve capacity before and after living kidney donation

2018 ◽  
Vol 315 (6) ◽  
pp. F1550-F1554 ◽  
Author(s):  
Marco van Londen ◽  
Nicolien Kasper ◽  
Niek R. Hessels ◽  
A. Lianne Messchendorp ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Kidney Function ◽  
Kidney Donation ◽  
Reserve Capacity ◽  
Living Kidney Donation ◽  
Functional Reserve ◽  
Dopamine Infusion ◽  
Renal Functional Reserve ◽  
Donor Screening

Compensatory gomerular filtration rate (GFR) increase after kidney donation results in a GFR above 50% of the predonation value. The renal functional reserve (RFR) assessed by the renal response to dopamine infusion (RFRdopa) is considered to reflect functional reserve capacity and is thought to be a tool for living donor screening. However, it is unknown if the RFRdopa predicts long-term kidney function. Between 1984 and 2017, we prospectively measured GFR (125I-iothalamate) and RFR by dopamine infusion in 937 living kidney donors. We performed linear regression analysis of predonation RFRdopa and postdonation GFR. In donors with 5-yr follow-up after donation we assessed the association with long-term GFR. Mean donor age was 52  yr (SD 11); 52% were female. Mean predonation GFR was 114  ml/min (SD 22), GFRdopa was 124 ml/min (SD 24), resulting in an RFR of 9 ml/min (SD 10). Three months postdonation, GFR was 72 ml/min (SD 15) and GFRdopa was 75 ml/min (SD 15), indicating that donors still had RFRdopa [3 ml/min (SD 6), P < 0.001]. Predonation RFRdopa was not associated with predonation GFR [standardized (st.) β −0.009, P = 0.77] but was positively associated with GFR 3 mo after donation (st. β 0.12, P < 0.001). In the subgroup of donors with 5-yr follow-up data ( n = 383), RFRdopa was not associated with GFR at 5 yr postdonation (st. β 0.05, P = 0.35). In conclusion, RFRdopa is a predictor of short-term GFR after living kidney donation but not of long-term kidney function. Therefore, measurement of the RFRdopa is not a useful tool for donor screening. Studies investigating long-term renal adaptation are warranted to study the effects of living kidney donation and improve donor screening.

Long-term studies of cisplatin-induced reductions in porcine renal functional reserve

1992 ◽  
Vol 29 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Mike E. C. Robbins ◽  
Tony Bywaters ◽  
Roger S. Jaenke ◽  
John W. Hopewell ◽  
Lillian M. Matheson ◽  
...  
Keyword(s):  
Functional Reserve ◽  
Renal Functional Reserve ◽  
Long Term Studies
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