scholarly journals A Prospective for the Potential Effect of Local Anesthetics on Stem-Like Cells in Colon Cancer

2020 ◽  
pp. 35-38
Author(s):  
Hengrui Liu
Keyword(s):  
Colon Cancer ◽  
Local Anesthetics ◽  
Cancer Biology ◽  
Cancer Recurrence ◽  
Potential Effect ◽  
Population Viability ◽  
Colon Cancer Stem Cell ◽  
Colon Cancer Cell Lines ◽  
And Migration ◽  
Colon Cancer Recurrence

Colorectal cancer is the third most prevalent cancer and the second most frequent cause of cancer-related death in the world. Surgical resection of the primary tumor is the central aspect of the current multiple modes of treatment and has been associated with better prognosis. The process of surgery, including anesthetic regimens, has increasingly been recognized to affect colon cancer recurrence and metastasis. Both retrospective clinical studies and laboratory studies have reported that colon cancer cells are inhibited by some local anesthetics. However, the application of local anesthetics in colon cancer treatment is limited by our understanding of the mechanisms underlying their effects on cancer biology. Local anesthetics have been proved to preferentially inhibit cancer stem cells which imply that local anesthetics target colon cancer stem cell to suppress cancer progressing. Here this paper will review and propose several potential studies, including using colon cancer cell lines and animal models to test the effect of local anesthetics on population, viability, and migration of colon cancer stem-like cell, and screen and search for potential molecular targets underlying these effects.

scholarly journals Accurate population-based model for individual prediction of colon cancer recurrence

2021 ◽  
pp. 1-9
Author(s):  
E. Osterman ◽  
J. Ekström ◽  
T. Sjöblom ◽  
H. Kørner ◽  
T. Å. Myklebust ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Recurrence ◽  
Population Based ◽  
Colon Cancer Recurrence

scholarly journals A CASE OF ASCENDING COLON CANCER RECURRENCE WITH INTRALUMINAL URETERAL DISSEMINATION MIMICKING PRIMARY URETERAL CANCER, DETECTED DURING INVESTIGATION FOR FEVER

2015 ◽  
Vol 106 (4) ◽  
pp. 264-268
Author(s):  
Ryuichi Nishiyama ◽  
Masashi Kubota ◽  
Toru Kanno ◽  
Takashi Okada ◽  
Yoshihito Higashi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Recurrence ◽  
Ascending Colon ◽  
Ascending Colon Cancer ◽  
Colon Cancer Recurrence

scholarly journals TWO CASES OF COLON CANCER RECURRENCE AT THE HAND-SEWN ANASTOMOSIS SITE AFTER COLECTOMY

2011 ◽  
Vol 72 (3) ◽  
pp. 732-736
Author(s):  
Chihiro NAKAHARA ◽  
Kumi SUYAMA ◽  
Toshimitsu IWASHITA ◽  
Satoshi TOYOSHIMA
Keyword(s):  
Colon Cancer ◽  
Cancer Recurrence ◽  
Anastomosis Site ◽  
Colon Cancer Recurrence

Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence

Cancer ◽  
2007 ◽  
Vol 110 (3) ◽  
pp. 534-542 ◽  
Author(s):  
Edward H. Lin ◽  
Manal Hassan ◽  
Yanan Li ◽  
Hua Zhao ◽  
Ajay Nooka ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Messenger Rna ◽  
Cancer Recurrence ◽  
Endothelial Progenitor ◽  
Colon Cancer Recurrence ◽  
Rna Levels

Statin use is associated with a reduced risk of colon cancer recurrence

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 4114-4114
Author(s):  
D. M. Anderson ◽  
J. Jackson ◽  
A. Butani ◽  
S. Asche ◽  
C. Rolnick
Keyword(s):  
Colon Cancer ◽  
Survival Data ◽  
Demographic Data ◽  
Cancer Recurrence ◽  
Tumor Registry ◽  
Patients Âgés ◽  
Significant Difference ◽  
Incident Cases ◽  
Colon Cancer Recurrence ◽  
Statin Use

4114 Background: A significant body of data suggests that statin use reduces the risk of developing colon and other cancers, although other data have not confirmed these findings. We examined whether statin use helps prevent recurrence of colon cancer in patients with resected disease. Methods: We conducted a retrospective analysis of patients treated for stage I, II, and III colon cancer in a Minneapolis/St. Paul health system. Incident cases of colon cancer between 1995 and the present were identified through a hospital tumor registry. All identified cases were then cross-checked against an HMO membership database. Data regarding statin use was pulled from the HMO outpatient pharmacy database. For each patient all available data from a 5-year window prior to first diagnosis of cancer until either recurrence or most recent data available was obtained. Demographic data and survival data from the tumor registry were then combined with pharmacy data regarding statin use in a single database for analysis. Recurrence and time to recurrent disease were compared in statin users and non-users. Results: A total of 358 colon cancer cases were available for analysis. Median follow up of patients after diagnosis of colon cancer was 49 months. 89 patients (24.9%) used statin drugs for some period of time with a median of 780 days of use. Median age of all patients enrolled was 69 (range 24–95). Statin use was higher in patients ages 61–75 (33%) than in those aged 24–60 (22%) or those aged 76–95 (19%) (p=0.02). There was no association between statin use and stage at diagnosis. 6 of 89 patients (6.7%) with any statin use relapsed as opposed to 43 of 269 (16%) of patients with no statin use (Fisher’s exact p=0.03). Kaplan-Meier analysis of relapse curves found a significant difference in relapse between groups with a two year recurrence rate of 3.7% among statin users and 10.1% among non users (Log Rank p=0.03, using age stratification). Conclusions: Statin use was associated with a decreased risk of recurrence in patients diagnosed with stages I-III colon cancer in this study. Further study of statin use in the prevention of colon cancer recurrence is warranted. No significant financial relationships to disclose.

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