JUSTIFICATION OF THE AREA OF THE ENGINE REPAIR SITE FOR ENTERPRISES OF THE KOSTANAY REGION

2021 ◽  
pp. 131-136
Author(s):  
SERIK K. TOJGAMBAEV
Keyword(s):  
Repair Site

Late complications at repair site of operated coarctation of aorta

1979 ◽  
Vol 133 (6) ◽  
pp. 1071-1075 ◽  
Author(s):  
RA Clark ◽  
DP Colley ◽  
E Siedlecki
Keyword(s):  
Late Complications ◽  
Coarctation Of Aorta ◽  
Repair Site

scholarly journals Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases

2019 ◽  
Vol 28 (7) ◽  
pp. 924-931
Author(s):  
Jingsong Wang ◽  
Karina T. Wright ◽  
Jade Perry ◽  
Bernhard Tins ◽  
Timothy Hopkins ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Knee Function ◽  
Cartilage Defects ◽  
Repair Site ◽  
Cell Implantation ◽  
Autologous Chondrocyte

Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects for >20 years, with promising clinical outcomes. Here, we report two first-in-man cases (patient A and B) treated with combined autologous chondrocyte and bone marrow mesenchymal stromal cell implantation (CACAMI), with 8-year follow up. Two patients with International Cartilage Repair Society (ICRS) grade III–IV cartilage lesions underwent a co-implantation of autologous chondrocytes and bone marrow-derived mesenchymal stromal cells (BM-MSCs) between February 2008 and October 2009. In brief, chondrocytes and BM-MSCs were separately isolated and culture-expanded in a good manufacturing practice laboratory for a period of 2–4 weeks. Cells were then implanted in combination into cartilage defects and patients were clinically evaluated preoperatively and postoperatively, using the self-reported Lysholm knee score and magnetic resonance imaging (MRI). Postoperative Lysholm scores were compared with the Oswestry risk of knee arthroplasty (ORKA) scores. Patient A also had a second-look arthroscopy, at which time a biopsy of the repair site was taken. Both patients demonstrated a significant long-term improvement in knee function, with postoperative Lysholm scores being consistently higher than ORKA predictions. The most recent Lysholm scores, 8 years after surgery were 100/100 (Patient A) and 88/100 (Patient B), where 100 represents a fully functioning knee joint. Bone marrow lesion (BML) volume was shown to decrease on postoperative MRIs in both patients. Cartilage defect area increased in patient A, but declined initially for patient B, slightly increasing again 2 years after treatment. The repair site biopsy taken from patient A at 14 months postoperatively, demonstrated a thin layer of fibrocartilage covering the treated defect site. The use of a combination of cultured autologous chondrocytes and BM-MSCs appears to confer long-term benefit in this two-patient case study. Improvements in knee function perhaps relate to the observed reduction in the size of the BML.

Repair Site Integrity after Arthroscopic Transosseous-Equivalent Suture-Bridge Rotator Cuff Repair

2008 ◽  
Vol 36 (8) ◽  
pp. 1496-1503 ◽  
Author(s):  
Joshua B. Frank ◽  
Neal S. ElAttrache ◽  
Joshua S. Dines ◽  
Allie Blackburn ◽  
John Crues ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Repair ◽  
Repair Site ◽  
Suture Bridge ◽  
Cuff Repair

Sonographic study of repair, gapping and tendon bowstringing after primary flexor digitorum profundus repair in zone 2

2018 ◽  
Vol 43 (5) ◽  
pp. 480-486 ◽  
Author(s):  
Lisa Reissner ◽  
Nadja Zechmann-Mueller ◽  
Holger Jan Klein ◽  
Maurizio Calcagni ◽  
Thomas Giesen
Keyword(s):  
Clinical Outcomes ◽  
Ultrasound Examination ◽  
Tendon Repair ◽  
Flexor Digitorum Profundus ◽  
Level Of Evidence ◽  
Repair Site ◽  
Heterotopic Ossifications ◽  
Finger Motion ◽  
Flexor Digitorum ◽  
Flexor Digitorum Profundus Tendon

We report sonographic findings with clinical outcomes after zone 2 flexor digitorum profundus tendon repairs in ten fingers. The tendons underwent a six-strand M-Tang core repair, no circumferential suture, and partial or complete division of the pulleys. Over 12 months after surgery and using ultrasound, we found no gapping at the repair site during finger motion. When the pulleys were divided, there was sonographic evidence of tendon bowstringing, but the bowstringing was minimal. Clinically, we did not find any fingers that displayed tendon bowstringing or had functional loss. With ultrasound examination, the repaired tendons remained enlarged over 12 months. Two patients developed heterotopic ossifications at the repair site without tendon gliding, and these required tenolysis. We conclude that the tendon repair site does not gap when a strong core suture is used in the repair without adding peripheral sutures. There is no notable tendon bowstringing clinically, though the repaired tendons have sonographic evidence of minor bowstringing. Level of evidence: III

Effects of human amniotic fluid on peripheral nerve scarring and regeneration in rats

2003 ◽  
Vol 98 (2) ◽  
pp. 371-377 ◽  
Author(s):  
Güzin Yeşim Özgenel ◽  
Gülaydan Filiz
Keyword(s):  
Peripheral Nerve ◽  
Amniotic Fluid ◽  
Nerve Regeneration ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Control Group ◽  
Human Amniotic Fluid ◽  
Content Type ◽  
Repair Site ◽  
Fine Print

Object. Peripheral nerve repair surgery is still replete with challenges. Despite technical improvements in microsurgery, classic methods of nerve repair have failed to provide satisfactory results. The purpose of this study was to investigate the effects of amniotic fluid from humans on peripheral nerve scarring and regeneration in rats. Methods. Forty adult Sprague—Dawley rats were used in this study. After the right sciatic nerve in each rat was transected and repaired using an epineural suture procedure, the nerves were divided into two groups according to the solution applied around the repair site: experimental group, 0.3 ml human amniotic fluid (HAF); and control group, 0.3 ml saline. Macroscopic and histological evaluations of peripheral nerve scarring were performed 4 weeks postsurgery. Nerves treated with HAF demonstrated a significant reduction in the amount of scar tissue surrounding the repair site (p < 0.05). No evidence of a reaction against HAF was noted. Functional nerve regeneration was measured once every 2 weeks by using a sciatic function index until 12 weeks postsurgery. Functional recovery in nerves treated with amniotic fluid occurred significantly faster than that in nerves treated with saline (p < 0.05). Peripheral nerve regeneration was evaluated histomorphologically at 12 weeks postsurgery. Nerves treated with amniotic fluid showed significant improvement with respect to the indices of fiber maturation (p < 0.05). Conclusions. Preliminary data show that HAF enhances peripheral nerve regeneration. The preventive effect of HAF on epineural scarring and the rich content of neurotrophic and neurite-promoting factors possibly contribute to this result.

Assessment of Axons from the Different Types of Neurons Regenerating Through Sites of Repair after Nerve Repair

1996 ◽  
Vol 21 (6) ◽  
pp. 830-830
Author(s):  
J-J. Xu ◽  
Y. Huang
Keyword(s):  
Axonal Regeneration ◽  
Nerve Repair ◽  
Muscle Spindles ◽  
Nerve Graft ◽  
Lower Limbs ◽  
Motor Axons ◽  
Repair Site ◽  
Sensory Axons ◽  
Different Types ◽  
Experimental Side

The percentage of axons from different types of neurons regenerating through the site of repair was assessed by retrograde horseradish peroxidase labelling in 30 male SD rats. These rats were randomly divided into groups and underwent epineurial, perineurial suturing and 4 mm nerve graft for transected peroneal nerves in lower limbs on one side. The contralateral nerves were not injured and served as controls. The number of labelled neurons in the experimental side divided by those in the control gave a percentage of regeneration. Four to 9 weeks after nerve repair, axonal regeneration through the repair site was assessed by number, location and diameter. Results revealed that the percentage of motor axons crossing the nerve repair site was the same as the sensory axons. The percentage of neurons with axons innervating muscle spindles was statistically lower that those innervating the other end organs. Perineurial repair produced a higher percentage of motor axons across the repair than epineurial repair or nerve graft.

The long-term results of hyoid-sternohyoid grafts in the correction of subglottic stenosis

1986 ◽  
Vol 100 (6) ◽  
pp. 665-674 ◽  
Author(s):  
A. P. Freeland
Keyword(s):  
Granulation Tissue ◽  
Major Complication ◽  
Subglottic Stenosis ◽  
Long Term Results ◽  
Repair Site ◽  
Long Term Follow Up

AbstractThe long-term follow-up of eight patients with established subglottic stenosis managed with a composite hyoid-sternohyoid graft is reported. Four of these patients were children. All but one of the patients were extubated within four months of surgery. The reconstructed airway is shown to grow with age and re-stenosis has not occurred. Apart from post-operative granulation tissue at the repair site, the major complication has been a breathy voice in two children due to overwidening of the larynx.

scholarly journals Defining the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing by combining lineage tracing and spatial transcriptomics

2021 ◽  
Author(s):  
Jessica E Ackerman ◽  
Katherine T Best ◽  
Samantha N Muscat ◽  
Chia-Lung Wu ◽  
Alayna E Loiselle
Keyword(s):  
Time Course ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
Tendon Repair ◽  
Tendon Healing ◽  
Cell Types ◽  
Healing Time ◽  
Lineage Tracing ◽  
Repair Site ◽  
Temporal And Spatial

The tendon healing process is regulated by the coordinated interaction of multiple cell types and molecular processes. However, these processes are not well-defined leading to a paucity of therapeutic approaches to enhance tendon healing. Scleraxis-lineage (ScxLin) cells are the major cellular component of adult tendon and make time-dependent contributions to the healing process. Prior work from our lab and others suggests heterogeneity within the broader ScxLin population over the course of tendon healing; therefore delineating the temporal and spatial contributions of these cells is critical to understanding and improving the healing process. In the present study we utilize lineage tracing of the adult ScxLin population to determine whether these cells undergo cellular activation and subsequent myofibroblast differentiation, which is associated with both proper healing and fibrotic progression in many tissues. We show that adult ScxLin cells undergo transient activation in the organized cellular bridge at the tendon repair site, contribute to the formation of an organized neo-tendon, and contribute to a persistent myofibroblast population in the native tendon stubs. The mechanisms dictating this highly specialized spatial response are unknown. We therefore utilized spatial transcriptomics to better define the spatio-molecular program of tendon healing. Integrated transcriptomic analyses across the healing time-course identifies five distinct molecular regions, including key interactions between the inflammatory bridging tissue and highly reactive tendon tissue at the repair site, with adult ScxLin cells being a central player in the transition from native tendon to reactive, remodeling tendon. Collectively, these data provide important insights into both the role of adult ScxLin cells during healing as well as the molecular mechanisms that underpin and coordinate the temporal and spatial healing phenotype, which can be leveraged to enhance the healing process.

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