LONG-TERM FUNCTIONING OF KIDNEY GRAFTS

Abstract Purpose of the study. To study the morphological changes of long-functioning kidney transplants and determine the main causes of transplant dysfunction. Materials and methods. A total of 52 recipients aged 20 to 70 years were analyzed retrospectively at different times after transplant surgery (5 to 22 years).Morphological changes in the kidney transplant are comparable according to light microscopy. The morphological changes in the graft were studied in the initial and long-term period. Morphological studies were conducted in monitoring mode. Results. In the early period after transplantation, ischemic injuries, primary graft function, and episodes of acute rejection were taken into account. In the distant period, morphological changes were evaluated in accordance with the recommendations of the Banff-classification.When analyzing long-term results, antigen- dependent (immune) and antigen-independent (visible) factors that affect the renal transplant are distinguished. The main clinical and laboratory indicators of allografts dysfunction are increased creatinine and proteinuria.In antigen-dependent forms (cellular, humoral and mixed rejection), humoral rejection is the most common (25%) allografts dysfunction.Antigen-independent forms of dysfunction (streptococcal infection 25%, inflammatory diseases 19,2%, recurrent pathology 3,8%, signs of cyclosporine nephrotoxicity in combination with other forms was found in 59,2%, nephrosclerosis 65,4%). Conclusions. The data obtained suggest that antigen-dependent (immune) factors, and in particular humoral rejection, are the most common cause of allografts dysfunction, and antigen- independent factors contribute to the progression of chronic rejection and the development of nephrosclerosis. Keywords: renal transplant, antigen-dependent, antigen-independent, dysfunction.

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Inflammatory disease of the womans reproductive system: modern trends in diagnosis and therapy (literature review)

GYNECOLOGY ◽

10.26442/20795696.2018.6.180072 ◽

2018 ◽

Vol 20 (6) ◽

pp. 35-41

Author(s):

T Yu Pestrikova ◽

I V Yurasov ◽

E A Yurasova

Keyword(s):

Genital Tract ◽

Inflammatory Diseases ◽

Diagnosis And Treatment ◽

Long Term Results ◽

Modern Approach ◽

Pelvic Organs ◽

Results Of Treatment ◽

Number Of Patients ◽

Diagnostic Approaches

Medical, social and economic relevance of inflammatory diseases of the woman's reproductive organs requires a very careful attitude to the diagnosis and treatment of this pathology. The number of patients with genital infections and inflammatory diseases of the pelvic organs can takes the first place in structure of gynecological morbidity, and is 60.4-65.0%, and this fact is not unique to Russia, but all over the world. Incidence rate of inflammatory diseases of the pelvic organs in the first decade of the twenty-first century is increased at 1.4 times in patients who are from 18 to 24 years old and at 1.8 times in patients aged 25-29 years. At the same time, the cost of diagnosis and treatment has increased, reaching 50-60% of the total cost of providing gynecological care for population. The inflammatory diseases of pelvic organs are a collective concept. It includes of various nosological forms. There are numerous contradictions in the views on diagnostic approaches and treatment tactics, the nature of screening and control over the long-term results of treatment, the etiological and pathogenetic significance of various microorganisms found in the genital tract in patients with inflammatory diseases of the pelvic organs. Currently, there are many opinions among specialists about diagnostic approaches and treatment tactics, the type of screening and monitoring the long-term results of treatment, the etiological and pathogenetic role of various microorganisms which can be found in the genital tract in patients with inflammatory diseases. This review presents the results of a modern approach to the diagnosis, management and rehabilitation of patients with inflammatory diseases of the pelvic organs.

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NFATC1genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients

Pharmacogenomics ◽

10.2217/pgs-2016-0171 ◽

2017 ◽

Vol 18 (4) ◽

pp. 381-392 ◽

Cited By ~ 3

Author(s):

Qinxia Xu ◽

Xiaoyan Qiu ◽

Zheng Jiao ◽

Ming Zhang ◽

Jianping Chen ◽

...

Keyword(s):

Renal Transplant ◽

Acute Rejection ◽

Graft Function ◽

Renal Transplant Recipients ◽

Transplant Recipients

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LONG-TERM RESULTS IN RENAL TRANSPLANT PATIENTS WITH VESICO-URETERAL REFLUX AND RECURRENT URINARY TRACT INFECTIONS TREATED WITH RE-URETEROCYSTONEOSTOMY USING THE LICH-GRÉGOIR TECHNIQUE

European Urology Supplements ◽

10.1016/s1569-9056(08)60499-6 ◽

2008 ◽

Vol 7 (3) ◽

pp. 196

Author(s):

M.C. Schumacher ◽

H. Danuser ◽

F.C. Burkhard ◽

F. Frey ◽

U.E. Studer

Keyword(s):

Urinary Tract ◽

Renal Transplant ◽

Urinary Tract Infections ◽

Long Term Results ◽

Transplant Patients ◽

Recurrent Urinary Tract Infections ◽

Renal Transplant Patients ◽

Tract Infections ◽

Vesico Ureteral Reflux

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Long-term results in mizoribine-treated renal transplant recipients: a prospective, randomized trial of mizoribine and azathioprine under cyclosporine-based immunosuppression

Transplantation Proceedings ◽

10.1016/s0041-1345(99)00599-0 ◽

1999 ◽

Vol 31 (7) ◽

pp. 2877-2879 ◽

Cited By ~ 35

Author(s):

K Tanabe ◽

T Tokumoto ◽

N Ishikawa ◽

A Kanematsu ◽

T Oshima ◽

...

Keyword(s):

Renal Transplant ◽

Randomized Trial ◽

Prospective Randomized Trial ◽

Long Term Results ◽

Renal Transplant Recipients ◽

Transplant Recipients

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Long-term results of 1047 cadaveric kidney transplantations with special emphasis on initial graft function and rejection

Transplant International ◽

10.1007/s001470050295 ◽

2000 ◽

Vol 13 (2) ◽

pp. 122-128 ◽

Cited By ~ 2

Author(s):

L. E. J. Kyllönen ◽

K. T. Salmela ◽

B. H. Eklund ◽

L. E. H. Halme ◽

K. A. V. Höckerstedt ◽

...

Keyword(s):

Graft Function ◽

Long Term Results ◽

Kidney Transplantations ◽

Cadaveric Kidney

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Surgical management of recurrent disc herniations with microdiscectomy and long-term results on life quality: Detailed analysis of 70 cases

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.165426 ◽

2016 ◽

Vol 7 (01) ◽

pp. 87-90 ◽

Cited By ~ 3

Author(s):

Serdal Albayrak ◽

Sait Ozturk ◽

Emre Durdag ◽

Ömer Ayden

Keyword(s):

Quality Of Life ◽

Facet Joint ◽

Lumbar Disc ◽

Life Quality ◽

Early Period ◽

Long Term Results ◽

Disc Herniations

ABSTRACT Background: Aim of this paper is to recall the surgical technique used in the recurrent lumbar disc herniations (LDHs) and to share our experiences. Materials and Methods: Out of series of 1115 patients who underwent operations for LDH between 2006 and 2013, 70 patients underwent re-operations, which were included in this study. During surgery, lateral decompression performed over the medial facet joint to the superior facet joint border was seen after widening the laminectomy defect, and microdiscectomy was performed. The demographic findings of the patients, their complaints in admission to hospital, the level of operation, the condition of dural injury, the first admission in the prospective analysis, and their quality of life were evaluated through the Oswestry scoring during their postoperative 1st, 3rd, 6th-month and 1st, 3rd, 5th and 7th-year follow-up. In the statical analysis, Friedman test was performed for the comparison of the Oswestry scores and Siegel Castellan test was used for the paired nonparametrical data. A P < 0.05 was considered statistically significant. Results: Considering the Oswestry Index during the follow-ups, the values in the postoperative early period and follow-ups were seen to be significantly lower than those at the time of admission to hospital (P < 0.05). None of the patients, who re-operated by microdiscectomy, presented with iatrogenic instability in 7 years follow-up period. Conclusion: Microdiscectomy performed through a proper technique in the re-operation of recurrent disc herniations eases complaints and improves the quality of life. Long-term follow-ups are required for more accurate results.

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